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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4XLS

Crystal structure of T. aquaticus transcription initiation complex with CarD containing upstream fork promoter.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed RNA polymerase activity
A0005737cellular_componentcytoplasm
A0006351biological_processDNA-templated transcription
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0034062molecular_function5'-3' RNA polymerase activity
A0046983molecular_functionprotein dimerization activity
B0000428cellular_componentDNA-directed RNA polymerase complex
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed RNA polymerase activity
B0005737cellular_componentcytoplasm
B0006351biological_processDNA-templated transcription
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0034062molecular_function5'-3' RNA polymerase activity
B0046983molecular_functionprotein dimerization activity
C0000428cellular_componentDNA-directed RNA polymerase complex
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed RNA polymerase activity
C0006351biological_processDNA-templated transcription
C0016740molecular_functiontransferase activity
C0016779molecular_functionnucleotidyltransferase activity
C0032549molecular_functionribonucleoside binding
C0034062molecular_function5'-3' RNA polymerase activity
D0000287molecular_functionmagnesium ion binding
D0000428cellular_componentDNA-directed RNA polymerase complex
D0003677molecular_functionDNA binding
D0003899molecular_functionDNA-directed RNA polymerase activity
D0006351biological_processDNA-templated transcription
D0008270molecular_functionzinc ion binding
D0016740molecular_functiontransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0034062molecular_function5'-3' RNA polymerase activity
D0046872molecular_functionmetal ion binding
E0000428cellular_componentDNA-directed RNA polymerase complex
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed RNA polymerase activity
E0006351biological_processDNA-templated transcription
E0016740molecular_functiontransferase activity
E0016779molecular_functionnucleotidyltransferase activity
E0034062molecular_function5'-3' RNA polymerase activity
F0003677molecular_functionDNA binding
F0003700molecular_functionDNA-binding transcription factor activity
F0006352biological_processDNA-templated transcription initiation
F0006355biological_processregulation of DNA-templated transcription
F0016987molecular_functionsigma factor activity
G0000428cellular_componentDNA-directed RNA polymerase complex
G0003677molecular_functionDNA binding
G0003899molecular_functionDNA-directed RNA polymerase activity
G0005737cellular_componentcytoplasm
G0006351biological_processDNA-templated transcription
G0016740molecular_functiontransferase activity
G0016779molecular_functionnucleotidyltransferase activity
G0034062molecular_function5'-3' RNA polymerase activity
G0046983molecular_functionprotein dimerization activity
H0000428cellular_componentDNA-directed RNA polymerase complex
H0003677molecular_functionDNA binding
H0003899molecular_functionDNA-directed RNA polymerase activity
H0005737cellular_componentcytoplasm
H0006351biological_processDNA-templated transcription
H0016740molecular_functiontransferase activity
H0016779molecular_functionnucleotidyltransferase activity
H0034062molecular_function5'-3' RNA polymerase activity
H0046983molecular_functionprotein dimerization activity
I0000428cellular_componentDNA-directed RNA polymerase complex
I0003677molecular_functionDNA binding
I0003899molecular_functionDNA-directed RNA polymerase activity
I0006351biological_processDNA-templated transcription
I0016740molecular_functiontransferase activity
I0016779molecular_functionnucleotidyltransferase activity
I0032549molecular_functionribonucleoside binding
I0034062molecular_function5'-3' RNA polymerase activity
J0000287molecular_functionmagnesium ion binding
J0000428cellular_componentDNA-directed RNA polymerase complex
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed RNA polymerase activity
J0006351biological_processDNA-templated transcription
J0008270molecular_functionzinc ion binding
J0016740molecular_functiontransferase activity
J0016779molecular_functionnucleotidyltransferase activity
J0034062molecular_function5'-3' RNA polymerase activity
J0046872molecular_functionmetal ion binding
K0000428cellular_componentDNA-directed RNA polymerase complex
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed RNA polymerase activity
K0006351biological_processDNA-templated transcription
K0016740molecular_functiontransferase activity
K0016779molecular_functionnucleotidyltransferase activity
K0034062molecular_function5'-3' RNA polymerase activity
L0003677molecular_functionDNA binding
L0003700molecular_functionDNA-binding transcription factor activity
L0006352biological_processDNA-templated transcription initiation
L0006355biological_processregulation of DNA-templated transcription
L0016987molecular_functionsigma factor activity
M0009303biological_processrRNA transcription
N0009303biological_processrRNA transcription
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue ZN D 2001
ChainResidue
DCYS1112
DARG1189
DCYS1194
DTHR1196
DCYS1201
DCYS1204
site_idAC2
Number of Residues5
Detailsbinding site for residue ZN D 2002
ChainResidue
DCYS73
DCYS76
DCYS58
DCYS60
DLYS62
site_idAC3
Number of Residues3
Detailsbinding site for residue MG D 2003
ChainResidue
DASP739
DASP741
DASP743
site_idAC4
Number of Residues6
Detailsbinding site for residue ZN J 2001
ChainResidue
JCYS1112
JARG1189
JCYS1194
JTHR1196
JCYS1201
JCYS1204
site_idAC5
Number of Residues5
Detailsbinding site for residue ZN J 2002
ChainResidue
JCYS58
JCYS60
JLYS62
JCYS73
JCYS76
site_idAC6
Number of Residues3
Detailsbinding site for residue MG J 2003
ChainResidue
JASP739
JASP741
JASP743
Functional Information from PROSITE/UniProt
site_idPS00716
Number of Residues27
DetailsSIGMA70_2 Sigma-70 factors family signature 2. TleEVGayfgVTrerIrQIEnkaLrkL
ChainResidueDetails
FTHR397-LEU423
site_idPS00867
Number of Residues8
DetailsCPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LIEANLRL
ChainResidueDetails
FLEU202-LEU209
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV
ChainResidueDetails
CGLY836-VAL848
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues38
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues140
DetailsRegion: {"description":"Sigma-70 factor domain-2"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues156
DetailsRegion: {"description":"Sigma-70 factor domain-3"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues104
DetailsRegion: {"description":"Sigma-70 factor domain-4"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsMotif: {"description":"Interaction with polymerase core subunit RpoC"}
ChainResidueDetails

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PDB entries from 2025-10-29

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