4XL1

Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0007154	biological_process	cell communication
B	0007219	biological_process	Notch signaling pathway
B	0007275	biological_process	multicellular organism development
B	0016020	cellular_component	membrane
D	0005509	molecular_function	calcium ion binding
E	0007154	biological_process	cell communication
E	0007219	biological_process	Notch signaling pathway
E	0007275	biological_process	multicellular organism development
E	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. ClNtlgsFeCqC

Chain	Residue	Details
A	CYS429-CYS440
A	CYS467-CYS478
A	CYS505-CYS516

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CnCrpGwqGPlC

Chain	Residue	Details
B	CYS239-CYS250
A	CYS438-CYS449
A	CYS476-CYS487
A	CYS514-CYS525

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CnCrpGWqgpl....C

Chain	Residue	Details
B	CYS239-CYS250
A	CYS438-CYS449
A	CYS476-CYS487
A	CYS514-CYS525

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site_id	PS01187
Number of Residues	27
Details	EGF_CA Calcium-binding EGF-like domain signature. DvDECalganp........Cehagk..ClNtlgsFeC

Chain	Residue	Details
A	ASP412-CYS438
A	ASP452-CYS476
A	ASN490-CYS514

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interaction with Notch1 => ECO:0000269|PubMed:25700513

Chain	Residue	Details
B	TRP111
A	GLU493
A	ASP507
A	LYS508
D	THR432
D	SER435
D	ASP452
D	VAL453
D	GLU455
D	ASP469
D	GLN470
B	CYS217
D	ASN490
D	THR491
D	GLU493
D	ASP507
D	LYS508
E	TRP111
E	CYS217
A	GLU455
A	ASP469
A	GLN470
A	ASN490
A	THR491

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site_id	SWS_FT_FI2
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25700513, ECO:0007744|PDB:4XL1

Chain	Residue	Details
B	VAL79
B	PHE109
B	ASN162
E	VAL79
E	PHE109
E	ASN162

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: O-linked (Glc...) serine => ECO:0000269|PubMed:25700513, ECO:0007744|PDB:4XL1

Chain	Residue	Details
A	SER435
D	SER435

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (Glc...) serine => ECO:0000269|PubMed:25700513

Chain	Residue	Details
A	SER458
A	SER496
D	SER458
D	SER496

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: O-linked (Fuc...) threonine => ECO:0000269|PubMed:25700513, ECO:0007744|PDB:4XL1

Chain	Residue	Details
A	THR466
D	THR466

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