4X6Z

Yeast 20S proteasome in complex with PR-VI modulator

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0003674	molecular_function	molecular_function
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0030163	biological_process	protein catabolic process
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0003674	molecular_function	molecular_function
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005839	cellular_component	proteasome core complex
2	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
2	0019774	cellular_component	proteasome core complex, beta-subunit complex
2	0030163	biological_process	protein catabolic process
2	0034515	cellular_component	proteasome storage granule
2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0043248	biological_process	proteasome assembly
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030163	biological_process	protein catabolic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030163	biological_process	protein catabolic process
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030163	biological_process	protein catabolic process
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0080129	biological_process	proteasome core complex assembly
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030163	biological_process	protein catabolic process
D	0034515	cellular_component	proteasome storage granule
D	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030163	biological_process	protein catabolic process
E	0034515	cellular_component	proteasome storage granule
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0003674	molecular_function	molecular_function
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030163	biological_process	protein catabolic process
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0003729	molecular_function	mRNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030163	biological_process	protein catabolic process
G	0034515	cellular_component	proteasome storage granule
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0004175	molecular_function	endopeptidase activity
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
H	0019774	cellular_component	proteasome core complex, beta-subunit complex
H	0030163	biological_process	protein catabolic process
H	0034515	cellular_component	proteasome storage granule
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0030163	biological_process	protein catabolic process
I	0034515	cellular_component	proteasome storage granule
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0030163	biological_process	protein catabolic process
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0061133	molecular_function	endopeptidase activator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0010498	biological_process	proteasomal protein catabolic process
K	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0030163	biological_process	protein catabolic process
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0061133	molecular_function	endopeptidase activator activity
L	0004175	molecular_function	endopeptidase activity
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005777	cellular_component	peroxisome
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
L	0019774	cellular_component	proteasome core complex, beta-subunit complex
L	0030163	biological_process	protein catabolic process
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0080129	biological_process	proteasome core complex assembly
M	0003674	molecular_function	molecular_function
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
M	0019774	cellular_component	proteasome core complex, beta-subunit complex
M	0030163	biological_process	protein catabolic process
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0003674	molecular_function	molecular_function
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0030163	biological_process	protein catabolic process
N	0034515	cellular_component	proteasome storage granule
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043248	biological_process	proteasome assembly
O	0003674	molecular_function	molecular_function
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030163	biological_process	protein catabolic process
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0003674	molecular_function	molecular_function
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0030163	biological_process	protein catabolic process
P	0034515	cellular_component	proteasome storage granule
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0003674	molecular_function	molecular_function
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0030163	biological_process	protein catabolic process
Q	0034515	cellular_component	proteasome storage granule
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0080129	biological_process	proteasome core complex assembly
R	0003674	molecular_function	molecular_function
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030163	biological_process	protein catabolic process
R	0034515	cellular_component	proteasome storage granule
R	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0003674	molecular_function	molecular_function
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0030163	biological_process	protein catabolic process
S	0034515	cellular_component	proteasome storage granule
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0003674	molecular_function	molecular_function
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0030163	biological_process	protein catabolic process
T	0034515	cellular_component	proteasome storage granule
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0003729	molecular_function	mRNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030163	biological_process	protein catabolic process
U	0034515	cellular_component	proteasome storage granule
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0004175	molecular_function	endopeptidase activity
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0030163	biological_process	protein catabolic process
V	0034515	cellular_component	proteasome storage granule
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0030163	biological_process	protein catabolic process
W	0034515	cellular_component	proteasome storage granule
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0030163	biological_process	protein catabolic process
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0061133	molecular_function	endopeptidase activator activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005737	cellular_component	cytoplasm
Y	0005789	cellular_component	endoplasmic reticulum membrane
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0030163	biological_process	protein catabolic process
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0061133	molecular_function	endopeptidase activator activity
Z	0004175	molecular_function	endopeptidase activity
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005777	cellular_component	peroxisome
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Z	0019774	cellular_component	proteasome core complex, beta-subunit complex
Z	0030163	biological_process	protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0080129	biological_process	proteasome core complex assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue MPD 1 301

Chain	Residue
1	TYR-4

---

site_id	AC2
Number of Residues	1
Details	binding site for residue GOL 1 302

Chain	Residue
1	TYR97

---

site_id	AC3
Number of Residues	1
Details	binding site for residue GOL 1 303

Chain	Residue
1	ARG92

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MPD 2 301

Chain	Residue
2	ARG153
2	GLU154

---

site_id	AC5
Number of Residues	1
Details	binding site for residue GOL 2 302

Chain	Residue
2	ASP193

---

site_id	AC6
Number of Residues	1
Details	binding site for residue GOL 2 303

Chain	Residue
2	ILE-3

---

site_id	AC7
Number of Residues	1
Details	binding site for residue MG 2 306

Chain	Residue
2	ASP152

---

site_id	AC8
Number of Residues	1
Details	binding site for residue MG 2 308

Chain	Residue
2	GLN94

---

site_id	AC9
Number of Residues	3
Details	binding site for residue GOL A 302

Chain	Residue
A	ARG46
A	GLY47
A	LYS48

---

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL A 303

Chain	Residue
A	TYR108
I	HIS66
I	TYR69

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL A 304

Chain	Residue
A	PHE73
A	LYS98
G	ASP113
H	GLN69

---

site_id	AD3
Number of Residues	4
Details	binding site for residue GOL D 301

Chain	Residue
D	ARG111
D	GLY115
D	HOH401
E	ARG86

---

site_id	AD4
Number of Residues	3
Details	binding site for residue GOL E 301

Chain	Residue
E	TYR167
E	ASN168
F	SER58

---

site_id	AD5
Number of Residues	2
Details	binding site for residue GOL F 301

Chain	Residue
F	ASN41
F	HOH406

---

site_id	AD6
Number of Residues	2
Details	binding site for residue GOL F 302

Chain	Residue
E	ARG122
F	ASN86

---

site_id	AD7
Number of Residues	4
Details	binding site for residue GOL F 304

Chain	Residue
F	PHE99
F	ARG101
F	ARG107
N	GLU65

---

site_id	AD8
Number of Residues	1
Details	binding site for residue MG F 305

Chain	Residue
F	GLU27

---

site_id	AD9
Number of Residues	1
Details	binding site for residue GOL G 301

Chain	Residue
G	TYR125

---

site_id	AE1
Number of Residues	3
Details	binding site for residue GOL G 302

Chain	Residue
G	GLU93
G	GLU94
G	SER97

---

site_id	AE2
Number of Residues	11
Details	binding site for residue GOL H 201

Chain	Residue
H	THR1
H	ARG19
H	THR20
H	LYS33
H	ARG45
H	SER46
H	GLY47
H	SER48
H	ALA49
H	THR52
H	HOH307

---

site_id	AE3
Number of Residues	4
Details	binding site for residue GOL I 301

Chain	Residue
H	THR22
H	ALA27
I	SER118
I	ASP120

---

site_id	AE4
Number of Residues	1
Details	binding site for residue GOL I 302

Chain	Residue
I	TYR97

---

site_id	AE5
Number of Residues	4
Details	binding site for residue MG J 201

Chain	Residue
I	CYS31
I	ALA32
J	ILE121
J	GLU123

---

site_id	AE6
Number of Residues	4
Details	binding site for residue GOL J 202

Chain	Residue
B	ARG99
I	GLN57
J	GLN80
J	SER83

---

site_id	AE7
Number of Residues	1
Details	binding site for residue MG J 204

Chain	Residue
J	PHE91

---

site_id	AE8
Number of Residues	1
Details	binding site for residue MG J 207

Chain	Residue
J	TYR94

---

site_id	AE9
Number of Residues	4
Details	binding site for residue GOL K 201

Chain	Residue
K	MET0
K	GLN98
K	ASN100
K	TYR120

---

site_id	AF1
Number of Residues	4
Details	binding site for residue MPD L 301

Chain	Residue
K	ARG22
L	GLY98
L	ASP116
L	ASP118

---

site_id	AF2
Number of Residues	4
Details	binding site for residue GOL L 302

Chain	Residue
L	ASP141
Y	LEU162
Y	GLU166
Y	LYS169

---

site_id	AF3
Number of Residues	2
Details	binding site for residue GOL L 303

Chain	Residue
L	ASN143
L	TYR155

---

site_id	AF4
Number of Residues	1
Details	binding site for residue MG L 304

Chain	Residue
L	THR1

---

site_id	AF5
Number of Residues	1
Details	binding site for residue MG L 305

Chain	Residue
L	GLN62

---

site_id	AF6
Number of Residues	3
Details	binding site for residue GOL M 302

Chain	Residue
L	TYR90
M	TYR89
M	GLY90

---

site_id	AF7
Number of Residues	4
Details	binding site for residue GOL M 303

Chain	Residue
M	ASN46
M	GLY47
M	TYR97
M	HOH407

---

site_id	AF8
Number of Residues	1
Details	binding site for residue MG M 304

Chain	Residue
M	TYR97

---

site_id	AF9
Number of Residues	2
Details	binding site for residue MPD N 301

Chain	Residue
M	HOH405
N	GLU154

---

site_id	AG1
Number of Residues	2
Details	binding site for residue GOL N 302

Chain	Residue
N	ASP39
N	GLY197

---

site_id	AG2
Number of Residues	2
Details	binding site for residue GOL O 301

Chain	Residue
O	TYR108
W	HIS66

---

site_id	AG3
Number of Residues	4
Details	binding site for residue GOL O 302

Chain	Residue
O	PHE73
O	LYS98
U	ASP113
V	GLN69

---

site_id	AG4
Number of Residues	1
Details	binding site for residue MG P 301

Chain	Residue
P	LEU250

---

site_id	AG5
Number of Residues	1
Details	binding site for residue MG R 303

Chain	Residue
R	GLU189

---

site_id	AG6
Number of Residues	2
Details	binding site for residue GOL S 301

Chain	Residue
S	ASN168
T	SER58

---

site_id	AG7
Number of Residues	5
Details	binding site for residue GOL T 302

Chain	Residue
T	HIS69
T	LYS102
T	GLY217
T	ASP219
T	PRO221

---

site_id	AG8
Number of Residues	1
Details	binding site for residue MG T 304

Chain	Residue
T	ASN93

---

site_id	AG9
Number of Residues	5
Details	binding site for residue MPD V 201

Chain	Residue
V	THR1
V	GLY47
V	GLY128
V	SER129
V	MG206

---

site_id	AH1
Number of Residues	2
Details	binding site for residue GOL V 202

Chain	Residue
2	GLN-6
V	ASP91

---

site_id	AH2
Number of Residues	6
Details	binding site for residue GOL V 203

Chain	Residue
V	THR20
V	THR31
V	ARG45
V	GLY47
V	ALA49
V	THR52

---

site_id	AH3
Number of Residues	2
Details	binding site for residue MG V 206

Chain	Residue
V	LEU115
V	MPD201

---

site_id	AH4
Number of Residues	2
Details	binding site for residue MG V 207

Chain	Residue
V	LEU93
V	THR94

---

site_id	AH5
Number of Residues	1
Details	binding site for residue GOL W 301

Chain	Residue
W	GLY128

---

site_id	AH6
Number of Residues	3
Details	binding site for residue MPD X 201

Chain	Residue
W	ALA54
W	GLN57
X	GLN80

---

site_id	AH7
Number of Residues	2
Details	binding site for residue MG X 203

Chain	Residue
X	LYS30
Y	VAL125

---

site_id	AH8
Number of Residues	1
Details	binding site for residue MG Y 201

Chain	Residue
Y	MET173

---

site_id	AH9
Number of Residues	6
Details	binding site for residue MPD Z 301

Chain	Residue
Z	THR1
Z	GLY47
Z	GLY130
Z	SER131
Z	GOL302
Z	HOH402

---

site_id	AI1
Number of Residues	2
Details	binding site for residue GOL Z 302

Chain	Residue
Z	ASP116
Z	MPD301

---

site_id	AI2
Number of Residues	1
Details	binding site for residue GOL Z 303

Chain	Residue
Z	TYR90

---

site_id	AI3
Number of Residues	2
Details	binding site for residue GOL Z 304

Chain	Residue
Z	ASN143
Z	TYR155

---

site_id	AI4
Number of Residues	1
Details	binding site for residue MG Z 305

Chain	Residue
Z	GLN62

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdlsnSvFSPdGRnfQVEYAvkA

Chain	Residue	Details
G	TYR7-ALA29
C	TYR6-SER28
B	TYR5-ALA27
D	TYR4-ALA26
A	TYR12-ALA34
E	TYR8-ALA30
F	TYR6-ALA28

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIrVqdSVILASSkavtrgisvlkdsdd.KtrqlsphtlmsfaGeaGD

Chain	Residue	Details
Y	LEU4-ASP51
H	MET4-ASP51
C	ILE36-ASP83
I	VAL4-ASP51
2	ILE4-ASP51
1	LEU4-ASP51
J	VAL4-ASP50
D	VAL34-ASP81
Z	LEU4-ASP51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9087403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	8
Details	M-CSA 177

Chain	Residue	Details
K	ASP29	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
K	PHE45	activator, steric locator
K	GLY47	activator
K	ALA61	activator, electrostatic stabiliser
K	SER75	electrostatic stabiliser
K	LEU157	activator, electrostatic stabiliser
K	PHE194	activator, steric locator
K	GLN197	activator, electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	8
Details	M-CSA 177

Chain	Residue	Details
Y	ASP29	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
Y	PHE45	activator, steric locator
Y	GLY47	activator
Y	ALA61	activator, electrostatic stabiliser
Y	SER75	electrostatic stabiliser
Y	LEU157	activator, electrostatic stabiliser
Y	PHE194	activator, steric locator
Y	GLN197	activator, electrostatic stabiliser

---