4X5T
alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue NI A 501 |
| Chain | Residue |
| A | ASP86 |
| A | ALA87 |
| A | ASP88 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | PHE78 |
| A | ARG85 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 503 |
| Chain | Residue |
| E | ARG105 |
| A | ARG77 |
| A | ILE131 |
| A | GLU181 |
| E | PHE42 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue NI B 501 |
| Chain | Residue |
| B | ASP86 |
| B | ALA87 |
| B | ASP88 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 502 |
| Chain | Residue |
| B | PRO74 |
| B | ILE76 |
| B | ARG85 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 503 |
| Chain | Residue |
| B | PHE78 |
| B | ARG85 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 504 |
| Chain | Residue |
| A | PHE42 |
| A | ARG105 |
| B | ARG77 |
| B | ILE131 |
| B | GLU181 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue NI C 501 |
| Chain | Residue |
| C | ASP86 |
| C | ALA87 |
| C | ASP88 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 502 |
| Chain | Residue |
| C | PHE78 |
| C | ARG85 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 503 |
| Chain | Residue |
| C | PRO74 |
| C | ILE76 |
| C | ARG85 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue ACT C 504 |
| Chain | Residue |
| B | PHE42 |
| B | ARG105 |
| C | ARG77 |
| C | ILE131 |
| C | GLU181 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue NI D 501 |
| Chain | Residue |
| D | PRO74 |
| D | ARG85 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue NI D 502 |
| Chain | Residue |
| D | ASP86 |
| D | ALA87 |
| D | ASP88 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT D 503 |
| Chain | Residue |
| C | PHE42 |
| C | ARG105 |
| D | ARG77 |
| D | ILE131 |
| D | GLU181 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue NI E 501 |
| Chain | Residue |
| E | ASP86 |
| E | ALA87 |
| E | ASP88 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue CL E 502 |
| Chain | Residue |
| E | PHE78 |
| E | ARG85 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT E 503 |
| Chain | Residue |
| D | PHE42 |
| D | ARG105 |
| E | ARG77 |
| E | ILE131 |
| E | GLU181 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"23994010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25730860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"23994010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25730860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"23994010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25730860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"23994010","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37821459","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DN5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16144831","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 228 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 35 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
