4X5F
ecDHFR complexed with folate and NADP+ at 0.1 MPa
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005542 | molecular_function | folic acid binding |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0009257 | biological_process | 10-formyltetrahydrofolate biosynthetic process |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0031427 | biological_process | response to methotrexate |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0046656 | biological_process | folic acid biosynthetic process |
A | 0046677 | biological_process | response to antibiotic |
A | 0050661 | molecular_function | NADP binding |
A | 0051870 | molecular_function | methotrexate binding |
A | 0051871 | molecular_function | dihydrofolic acid binding |
A | 0070401 | molecular_function | NADP+ binding |
A | 0070402 | molecular_function | NADPH binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005542 | molecular_function | folic acid binding |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0009257 | biological_process | 10-formyltetrahydrofolate biosynthetic process |
B | 0009410 | biological_process | response to xenobiotic stimulus |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0031427 | biological_process | response to methotrexate |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0046656 | biological_process | folic acid biosynthetic process |
B | 0046677 | biological_process | response to antibiotic |
B | 0050661 | molecular_function | NADP binding |
B | 0051870 | molecular_function | methotrexate binding |
B | 0051871 | molecular_function | dihydrofolic acid binding |
B | 0070401 | molecular_function | NADP+ binding |
B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue FOL A 201 |
Chain | Residue |
A | ILE5 |
A | ILE94 |
A | THR113 |
A | NAP202 |
A | HOH358 |
A | HOH367 |
A | HOH369 |
A | HOH402 |
A | ALA6 |
A | ALA7 |
A | ASP27 |
A | PHE31 |
A | LYS32 |
A | ILE50 |
A | ARG52 |
A | ARG57 |
site_id | AC2 |
Number of Residues | 28 |
Details | binding site for residue NAP A 202 |
Chain | Residue |
A | ALA6 |
A | ALA7 |
A | ILE14 |
A | GLY15 |
A | GLY43 |
A | ARG44 |
A | HIS45 |
A | THR46 |
A | LEU62 |
A | SER63 |
A | SER64 |
A | LYS76 |
A | ILE94 |
A | GLY96 |
A | GLY97 |
A | ARG98 |
A | VAL99 |
A | TYR100 |
A | GLN102 |
A | FOL201 |
A | HOH305 |
A | HOH308 |
A | HOH332 |
A | HOH345 |
A | HOH371 |
A | HOH377 |
A | HOH383 |
A | HOH403 |
site_id | AC3 |
Number of Residues | 1 |
Details | binding site for residue BME A 203 |
Chain | Residue |
A | CYS152 |
site_id | AC4 |
Number of Residues | 16 |
Details | binding site for residue FOL B 201 |
Chain | Residue |
B | ILE5 |
B | ALA6 |
B | ALA7 |
B | ASP27 |
B | LEU28 |
B | PHE31 |
B | LYS32 |
B | ARG52 |
B | ARG57 |
B | ILE94 |
B | THR113 |
B | NAP202 |
B | HOH368 |
B | HOH381 |
B | HOH392 |
B | HOH395 |
site_id | AC5 |
Number of Residues | 30 |
Details | binding site for residue NAP B 202 |
Chain | Residue |
B | ALA6 |
B | ALA7 |
B | ILE14 |
B | GLY15 |
B | MET16 |
B | GLY43 |
B | ARG44 |
B | HIS45 |
B | THR46 |
B | SER49 |
B | LEU62 |
B | SER63 |
B | SER64 |
B | LYS76 |
B | ILE94 |
B | GLY96 |
B | GLY97 |
B | ARG98 |
B | VAL99 |
B | TYR100 |
B | GLN102 |
B | FOL201 |
B | HOH304 |
B | HOH311 |
B | HOH331 |
B | HOH338 |
B | HOH347 |
B | HOH379 |
B | HOH382 |
B | HOH395 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue BME B 203 |
Chain | Residue |
B | HIS114 |
B | CYS152 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT |
Chain | Residue | Details |
A | VAL13-THR35 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000305|PubMed:9012674 |
Chain | Residue | Details |
A | ILE5 | |
B | THR113 | |
A | ASP27 | |
A | ARG52 | |
A | ARG57 | |
A | THR113 | |
B | ILE5 | |
B | ASP27 | |
B | ARG52 | |
B | ARG57 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19374017 |
Chain | Residue | Details |
A | ALA7 | |
B | SER63 | |
B | LYS76 | |
B | GLY95 | |
A | VAL13 | |
A | HIS45 | |
A | SER63 | |
A | LYS76 | |
A | GLY95 | |
B | ALA7 | |
B | VAL13 | |
B | HIS45 |