4X4V
Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a human MenBeta minihelix ending in CCACC and AMPcPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0001680 | biological_process | tRNA 3'-terminal CCA addition |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004810 | molecular_function | CCA tRNA nucleotidyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008033 | biological_process | tRNA processing |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0031123 | biological_process | RNA 3'-end processing |
| A | 0042245 | biological_process | RNA repair |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0106354 | biological_process | tRNA surveillance |
| A | 0160016 | molecular_function | CCACCA tRNA nucleotidyltransferase activity |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0001680 | biological_process | tRNA 3'-terminal CCA addition |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004810 | molecular_function | CCA tRNA nucleotidyltransferase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0008033 | biological_process | tRNA processing |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0031123 | biological_process | RNA 3'-end processing |
| C | 0042245 | biological_process | RNA repair |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0106354 | biological_process | tRNA surveillance |
| C | 0160016 | molecular_function | CCACCA tRNA nucleotidyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue APC A 501 |
| Chain | Residue |
| A | GLY46 |
| A | ARG224 |
| A | MG502 |
| A | HOH623 |
| A | HOH627 |
| A | HOH628 |
| A | HOH653 |
| B | A35 |
| B | C36 |
| B | C37 |
| B | HOH601 |
| A | SER47 |
| A | ARG50 |
| A | GLU59 |
| A | ASP61 |
| A | THR130 |
| A | HIS133 |
| A | LYS152 |
| A | TYR161 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | SER47 |
| A | GLU59 |
| A | ASP61 |
| A | APC501 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue TAR A 503 |
| Chain | Residue |
| A | VAL200 |
| A | ARG209 |
| A | PHE215 |
| A | VAL217 |
| A | GLU222 |
| A | HOH670 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue TAR A 504 |
| Chain | Residue |
| A | ARG310 |
| A | GLU311 |
| A | ASN312 |
| A | ARG380 |
| A | HOH717 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MES A 505 |
| Chain | Residue |
| A | ARG93 |
| A | TYR94 |
| A | ILE288 |
| A | VAL289 |
| A | ASN292 |
| A | HOH730 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue TAR B 501 |
| Chain | Residue |
| A | HIS396 |
| B | G11 |
| B | G12 |
| B | C21 |
| B | C22 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue 5GP B 502 |
| Chain | Residue |
| B | U14 |
| B | G16 |
| B | A17 |
| B | U19 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GMP B 503 |
| Chain | Residue |
| A | GLY346 |
| A | ASN354 |
| A | ARG373 |
| B | C15 |
| B | G16 |
| B | G18 |
| B | 5GP502 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue APC C 501 |
| Chain | Residue |
| C | SER47 |
| C | ARG50 |
| C | GLU59 |
| C | ASP61 |
| C | THR130 |
| C | HIS133 |
| C | LYS152 |
| C | TYR161 |
| C | ARG224 |
| C | MG502 |
| C | HOH645 |
| C | HOH655 |
| D | A35 |
| D | C36 |
| D | C37 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue MG C 502 |
| Chain | Residue |
| C | GLU59 |
| C | ASP61 |
| C | APC501 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue TAR C 503 |
| Chain | Residue |
| C | GLU311 |
| C | PHE342 |
| C | LYS381 |
| C | PHE382 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue GMP D 101 |
| Chain | Residue |
| D | G16 |
| D | A17 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0000269|PubMed:14636575, ECO:0000269|PubMed:25640237, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEU, ECO:0007744|PDB:4X4O, ECO:0007744|PDB:4X4Q, ECO:0007744|PDB:4X4S |
| Chain | Residue | Details |
| A | SER47 | |
| C | SER47 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0000269|PubMed:14636575, ECO:0000269|PubMed:25640237, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEU, ECO:0007744|PDB:4X4Q, ECO:0007744|PDB:4X4S |
| Chain | Residue | Details |
| A | ARG50 | |
| A | HIS133 | |
| A | LYS152 | |
| A | TYR161 | |
| C | ARG50 | |
| C | HIS133 | |
| C | LYS152 | |
| C | TYR161 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0007744|PDB:1UEV |
| Chain | Residue | Details |
| A | GLU59 | |
| C | GLU59 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEV |
| Chain | Residue | Details |
| A | ASP61 | |
| A | ASP110 | |
| C | ASP61 | |
| C | ASP110 |
