4X4V

Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a human MenBeta minihelix ending in CCACC and AMPcPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001680	biological_process	tRNA 3'-terminal CCA addition
A	0003723	molecular_function	RNA binding
A	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008033	biological_process	tRNA processing
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	0042245	biological_process	RNA repair
A	0046872	molecular_function	metal ion binding
A	0106354	biological_process	tRNA surveillance
A	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001680	biological_process	tRNA 3'-terminal CCA addition
C	0003723	molecular_function	RNA binding
C	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
C	0005524	molecular_function	ATP binding
C	0008033	biological_process	tRNA processing
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0031123	biological_process	RNA 3'-end processing
C	0042245	biological_process	RNA repair
C	0046872	molecular_function	metal ion binding
C	0106354	biological_process	tRNA surveillance
C	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue APC A 501

Chain	Residue
A	GLY46
A	ARG224
A	MG502
A	HOH623
A	HOH627
A	HOH628
A	HOH653
B	A35
B	C36
B	C37
B	HOH601
A	SER47
A	ARG50
A	GLU59
A	ASP61
A	THR130
A	HIS133
A	LYS152
A	TYR161

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 502

Chain	Residue
A	SER47
A	GLU59
A	ASP61
A	APC501

---

site_id	AC3
Number of Residues	6
Details	binding site for residue TAR A 503

Chain	Residue
A	VAL200
A	ARG209
A	PHE215
A	VAL217
A	GLU222
A	HOH670

---

site_id	AC4
Number of Residues	5
Details	binding site for residue TAR A 504

Chain	Residue
A	ARG310
A	GLU311
A	ASN312
A	ARG380
A	HOH717

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MES A 505

Chain	Residue
A	ARG93
A	TYR94
A	ILE288
A	VAL289
A	ASN292
A	HOH730

---

site_id	AC6
Number of Residues	5
Details	binding site for residue TAR B 501

Chain	Residue
A	HIS396
B	G11
B	G12
B	C21
B	C22

---

site_id	AC7
Number of Residues	4
Details	binding site for residue 5GP B 502

Chain	Residue
B	U14
B	G16
B	A17
B	U19

---

site_id	AC8
Number of Residues	7
Details	binding site for residue GMP B 503

Chain	Residue
A	GLY346
A	ASN354
A	ARG373
B	C15
B	G16
B	G18
B	5GP502

---

site_id	AC9
Number of Residues	15
Details	binding site for residue APC C 501

Chain	Residue
C	SER47
C	ARG50
C	GLU59
C	ASP61
C	THR130
C	HIS133
C	LYS152
C	TYR161
C	ARG224
C	MG502
C	HOH645
C	HOH655
D	A35
D	C36
D	C37

---

site_id	AD1
Number of Residues	3
Details	binding site for residue MG C 502

Chain	Residue
C	GLU59
C	ASP61
C	APC501

---

site_id	AD2
Number of Residues	4
Details	binding site for residue TAR C 503

Chain	Residue
C	GLU311
C	PHE342
C	LYS381
C	PHE382

---

site_id	AD3
Number of Residues	2
Details	binding site for residue GMP D 101

Chain	Residue
D	G16
D	A17

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14636575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14636575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UEV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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