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4WW2

Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8, Beta Chain-TRBV7-8, Antigen-presenting glycoprotein CD1d, and Beta-2-microglobulin

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0005886cellular_componentplasma membrane
A0009617biological_processresponse to bacterium
A0042101cellular_componentT cell receptor complex
F0000139cellular_componentGolgi membrane
F0001913biological_processT cell mediated cytotoxicity
F0001916biological_processpositive regulation of T cell mediated cytotoxicity
F0002237biological_processresponse to molecule of bacterial origin
F0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
F0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F0002502biological_processpeptide antigen assembly with MHC class I protein complex
F0002503biological_processpeptide antigen assembly with MHC class II protein complex
F0002726biological_processpositive regulation of T cell cytokine production
F0005198molecular_functionstructural molecule activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005765cellular_componentlysosomal membrane
F0005783cellular_componentendoplasmic reticulum
F0005788cellular_componentendoplasmic reticulum lumen
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006826biological_processiron ion transport
F0006879biological_processintracellular iron ion homeostasis
F0006955biological_processimmune response
F0007608biological_processsensory perception of smell
F0007611biological_processlearning or memory
F0009897cellular_componentexternal side of plasma membrane
F0009986cellular_componentcell surface
F0010977biological_processnegative regulation of neuron projection development
F0012507cellular_componentER to Golgi transport vesicle membrane
F0016020cellular_componentmembrane
F0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
F0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
F0023026molecular_functionMHC class II protein complex binding
F0030670cellular_componentphagocytic vesicle membrane
F0031901cellular_componentearly endosome membrane
F0031902cellular_componentlate endosome membrane
F0031905cellular_componentearly endosome lumen
F0032092biological_processpositive regulation of protein binding
F0033077biological_processT cell differentiation in thymus
F0034756biological_processregulation of iron ion transport
F0035580cellular_componentspecific granule lumen
F0042026biological_processprotein refolding
F0042605molecular_functionpeptide antigen binding
F0042612cellular_componentMHC class I protein complex
F0042613cellular_componentMHC class II protein complex
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0042824cellular_componentMHC class I peptide loading complex
F0045646biological_processregulation of erythrocyte differentiation
F0048260biological_processpositive regulation of receptor-mediated endocytosis
F0050680biological_processnegative regulation of epithelial cell proliferation
F0050768biological_processnegative regulation of neurogenesis
F0050778biological_processpositive regulation of immune response
F0050870biological_processpositive regulation of T cell activation
F0051289biological_processprotein homotetramerization
F0055038cellular_componentrecycling endosome membrane
F0060586biological_processmulticellular organismal-level iron ion homeostasis
F0070062cellular_componentextracellular exosome
F0071281biological_processcellular response to iron ion
F0071283biological_processcellular response to iron(III) ion
F0071316biological_processcellular response to nicotine
F1900121biological_processnegative regulation of receptor binding
F1900122biological_processpositive regulation of receptor binding
F1904434biological_processpositive regulation of ferrous iron binding
F1904437biological_processpositive regulation of transferrin receptor binding
F1904724cellular_componenttertiary granule lumen
F1990000biological_processamyloid fibril formation
F1990712cellular_componentHFE-transferrin receptor complex
F2000774biological_processpositive regulation of cellular senescence
F2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
FTYR78-HIS84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
BASN194
AASN77

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19349973
ChainResidueDetails
AASN159
AASN193

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AASN204
FLYS41
FLYS48
FLYS58
FLYS91
FLYS94

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN108
CASN163

223166

PDB entries from 2024-07-31

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