4WTV
Crystal structure of the phosphatidylinositol 4-kinase IIbeta
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0004430 | molecular_function | 1-phosphatidylinositol 4-kinase activity |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
| B | 0003796 | molecular_function | lysozyme activity |
| B | 0004430 | molecular_function | 1-phosphatidylinositol 4-kinase activity |
| B | 0009253 | biological_process | peptidoglycan catabolic process |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016998 | biological_process | cell wall macromolecule catabolic process |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue ATP A 1201 |
| Chain | Residue |
| A | SER133 |
| A | HOH1322 |
| A | HOH1367 |
| A | HOH1426 |
| A | HOH1433 |
| B | TYR268 |
| B | ARG271 |
| B | LYS272 |
| A | VAL146 |
| A | LYS148 |
| A | GLN257 |
| A | LEU258 |
| A | PHE259 |
| A | VAL260 |
| A | ILE343 |
| A | ASP344 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue ATP B 1201 |
| Chain | Residue |
| A | ARG271 |
| A | LYS272 |
| B | SER131 |
| B | SER133 |
| B | PHE135 |
| B | VAL146 |
| B | LYS148 |
| B | GLN257 |
| B | LEU258 |
| B | PHE259 |
| B | VAL260 |
| B | ILE343 |
| B | ASP344 |
| B | HOH1349 |
| B | HOH1360 |
| B | HOH1399 |
| B | HOH1436 |
| B | HOH1446 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26143926, ECO:0007744|PDB:4WTV |
| Chain | Residue | Details |
| A | SER133 | |
| B | ASP344 | |
| A | LYS148 | |
| A | GLN257 | |
| A | ARG271 | |
| A | ASP344 | |
| B | SER133 | |
| B | LYS148 | |
| B | GLN257 | |
| B | ARG271 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | GLU1010 | |
| B | GLU1010 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | ASP1019 | |
| B | ASP1019 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | LEU1031 | |
| A | PHE1103 | |
| B | LEU1031 | |
| B | PHE1103 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
| Chain | Residue | Details |
| A | SER1116 | |
| A | ASN1131 | |
| B | SER1116 | |
| B | ASN1131 |
