4WIO
Crystal structure of the C89A GMP synthetase inactive mutant from Plasmodium falciparum in complex with glutamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003921 | molecular_function | GMP synthase activity |
| A | 0003922 | molecular_function | GMP synthase (glutamine-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046037 | biological_process | GMP metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue GLN A 601 |
| Chain | Residue |
| A | GLY58 |
| A | HIS208 |
| A | TYR60 |
| A | ALA89 |
| A | TYR90 |
| A | GLN93 |
| A | ASN169 |
| A | HIS170 |
| A | ASN171 |
| A | ASP172 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile; for GATase activity => ECO:0000255|PROSITE-ProRule:PRU00605, ECO:0000305|PubMed:21413787, ECO:0000305|PubMed:26592566 |
| Chain | Residue | Details |
| A | ALA89 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: For GATase activity => ECO:0000255|PROSITE-ProRule:PRU00605 |
| Chain | Residue | Details |
| A | HIS208 | |
| A | GLU210 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26592566, ECO:0007744|PDB:4WIO |
| Chain | Residue | Details |
| A | GLN93 | |
| A | ASN169 | |
| A | ASP172 | |
| A | HIS208 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00886 |
| Chain | Residue | Details |
| A | SER262 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|Ref.6, ECO:0007744|PDB:3UOW |
| Chain | Residue | Details |
| A | ARG336 | |
| A | GLN476 | |
| A | LYS547 | |
| A | ILE552 | |
| A | GLU553 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Important for ATPPase activity => ECO:0000269|PubMed:32358899 |
| Chain | Residue | Details |
| A | ASP371 | |
| A | HIS388 | |
| A | HIS389 |
