4W8F
Crystal structure of the dynein motor domain in the AMPPNP-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0007018 | biological_process | microtubule-based movement |
| A | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030286 | cellular_component | dynein complex |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
| A | 0045505 | molecular_function | dynein intermediate chain binding |
| A | 0051959 | molecular_function | dynein light intermediate chain binding |
| B | 0003796 | molecular_function | lysozyme activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0007018 | biological_process | microtubule-based movement |
| B | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| B | 0009253 | biological_process | peptidoglycan catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016998 | biological_process | cell wall macromolecule catabolic process |
| B | 0030286 | cellular_component | dynein complex |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0044659 | biological_process | viral release from host cell by cytolysis |
| B | 0045505 | molecular_function | dynein intermediate chain binding |
| B | 0051959 | molecular_function | dynein light intermediate chain binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue ANP A 5001 |
| Chain | Residue |
| A | ILE1770 |
| A | ILE1929 |
| A | LEU1970 |
| A | LYS1974 |
| A | ALA1798 |
| A | GLY1799 |
| A | THR1800 |
| A | GLY1801 |
| A | LYS1802 |
| A | THR1803 |
| A | GLU1804 |
| A | ASN1899 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue ANP A 5002 |
| Chain | Residue |
| A | SER2048 |
| A | PHE2053 |
| A | GLY2077 |
| A | CYS2078 |
| A | GLY2079 |
| A | LYS2080 |
| A | THR2081 |
| A | ALA2082 |
| A | GLU2195 |
| A | VAL2219 |
| A | CYS2220 |
| A | LYS2225 |
| A | HIS2228 |
| A | ARG2507 |
| A | ARG2549 |
| A | ARG2552 |
| A | MG5005 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue ANP A 5003 |
| Chain | Residue |
| A | ILE2392 |
| A | PRO2420 |
| A | GLY2421 |
| A | GLY2423 |
| A | LYS2424 |
| A | THR2425 |
| A | MET2426 |
| A | GLU2488 |
| A | ASN2536 |
| A | ILE2570 |
| A | ARG2620 |
| A | THR2623 |
| A | PRO2906 |
| A | ARG2911 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue ANP A 5004 |
| Chain | Residue |
| A | MET2732 |
| A | VAL2733 |
| A | ARG2763 |
| A | THR2764 |
| A | GLY2765 |
| A | LYS2766 |
| A | THR2767 |
| A | ILE2768 |
| A | ASP2818 |
| A | CYS2892 |
| A | ILE2993 |
| A | ARG3512 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 5005 |
| Chain | Residue |
| A | THR2081 |
| A | GLU2195 |
| A | GLU2511 |
| A | ANP5002 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue ANP B 5001 |
| Chain | Residue |
| B | ILE1770 |
| B | GLY1799 |
| B | GLY1801 |
| B | LYS1802 |
| B | THR1803 |
| B | GLU1804 |
| B | ASP1848 |
| B | ASN1899 |
| B | ILE1929 |
| B | LEU1970 |
| B | ARG1971 |
| B | LYS1974 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue ANP B 5002 |
| Chain | Residue |
| B | PHE2047 |
| B | SER2048 |
| B | PHE2053 |
| B | GLY2077 |
| B | GLY2079 |
| B | LYS2080 |
| B | THR2081 |
| B | ALA2082 |
| B | GLU2195 |
| B | VAL2219 |
| B | CYS2220 |
| B | LYS2225 |
| B | HIS2228 |
| B | ARG2507 |
| B | GLU2511 |
| B | ARG2549 |
| B | ARG2552 |
| B | MG5005 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | binding site for residue ANP B 5003 |
| Chain | Residue |
| B | ILE2570 |
| B | TYR2574 |
| B | ARG2620 |
| B | THR2623 |
| B | ALA2907 |
| B | ARG2911 |
| B | ILE2392 |
| B | PRO2420 |
| B | GLY2421 |
| B | SER2422 |
| B | GLY2423 |
| B | LYS2424 |
| B | THR2425 |
| B | MET2426 |
| B | GLU2488 |
| B | ASN2536 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue ANP B 5004 |
| Chain | Residue |
| B | MET2732 |
| B | VAL2733 |
| B | SER2762 |
| B | ARG2763 |
| B | GLY2765 |
| B | LYS2766 |
| B | THR2767 |
| B | ILE2768 |
| B | CYS2892 |
| B | TRP2920 |
| B | MET2932 |
| B | ARG3512 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 5005 |
| Chain | Residue |
| B | THR2081 |
| B | GLU2195 |
| B | GLU2511 |
| B | ANP5002 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1892846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 442 |
| Details | Region: {"description":"AAA 1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 474 |
| Details | Region: {"description":"AAA 2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 498 |
| Details | Region: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 229 |
| Details | Region: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 420 |
| Details | Region: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 200 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 56 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
