4V2G
Tetracycline repressor TetR(D) bound to chlortetracycline and iso- chlortetracycline
Replaces: 1BJYFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ITC A 222 |
| Chain | Residue |
| A | HIS64 |
| A | SER138 |
| A | HIS139 |
| A | HOH2010 |
| B | LEU170 |
| B | LEU174 |
| A | ASN82 |
| A | PHE86 |
| A | HIS100 |
| A | ARG104 |
| A | PRO105 |
| A | VAL113 |
| A | GLN116 |
| A | ILE134 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CTC B 222 |
| Chain | Residue |
| A | LEU170 |
| A | LEU174 |
| A | HOH2005 |
| A | HOH2015 |
| B | HIS64 |
| B | SER67 |
| B | ASN82 |
| B | PHE86 |
| B | HIS100 |
| B | ARG104 |
| B | VAL113 |
| B | GLN116 |
| B | ILE134 |
| B | SER138 |
| B | MG223 |
| B | HOH2008 |
| B | HOH2009 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 223 |
| Chain | Residue |
| A | GLU147 |
| A | HOH2014 |
| A | HOH2015 |
| B | HIS100 |
| B | CTC222 |
| B | HOH2008 |
Functional Information from PROSITE/UniProt
| site_id | PS01081 |
| Number of Residues | 32 |
| Details | HTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL |
| Chain | Residue | Details |
| A | GLY21-LEU52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | Domain: {"description":"HTH tetR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8153629","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2TRT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
