4V0U

The crystal structure of ternary PP1G-PPP1R15B and G-actin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001725	cellular_component	stress fiber
A	0003785	molecular_function	actin monomer binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005523	molecular_function	tropomyosin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0019904	molecular_function	protein domain specific binding
A	0030027	cellular_component	lamellipodium
A	0030041	biological_process	actin filament polymerization
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031013	molecular_function	troponin I binding
A	0031432	molecular_function	titin binding
A	0031941	cellular_component	filamentous actin
A	0032036	molecular_function	myosin heavy chain binding
A	0032432	cellular_component	actin filament bundle
A	0042802	molecular_function	identical protein binding
A	0044297	cellular_component	cell body
A	0048306	molecular_function	calcium-dependent protein binding
A	0048741	biological_process	skeletal muscle fiber development
A	0051017	biological_process	actin filament bundle assembly
A	0090131	biological_process	mesenchyme migration
A	0098723	cellular_component	skeletal muscle myofibril
A	0140660	molecular_function	cytoskeletal motor activator activity
B	0000287	molecular_function	magnesium ion binding
B	0001725	cellular_component	stress fiber
B	0003785	molecular_function	actin monomer binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005523	molecular_function	tropomyosin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0019904	molecular_function	protein domain specific binding
B	0030027	cellular_component	lamellipodium
B	0030041	biological_process	actin filament polymerization
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031013	molecular_function	troponin I binding
B	0031432	molecular_function	titin binding
B	0031941	cellular_component	filamentous actin
B	0032036	molecular_function	myosin heavy chain binding
B	0032432	cellular_component	actin filament bundle
B	0042802	molecular_function	identical protein binding
B	0044297	cellular_component	cell body
B	0048306	molecular_function	calcium-dependent protein binding
B	0048741	biological_process	skeletal muscle fiber development
B	0051017	biological_process	actin filament bundle assembly
B	0090131	biological_process	mesenchyme migration
B	0098723	cellular_component	skeletal muscle myofibril
B	0140660	molecular_function	cytoskeletal motor activator activity
C	0000287	molecular_function	magnesium ion binding
C	0001725	cellular_component	stress fiber
C	0003785	molecular_function	actin monomer binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005523	molecular_function	tropomyosin binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030027	cellular_component	lamellipodium
C	0030041	biological_process	actin filament polymerization
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031013	molecular_function	troponin I binding
C	0031432	molecular_function	titin binding
C	0031941	cellular_component	filamentous actin
C	0032036	molecular_function	myosin heavy chain binding
C	0032432	cellular_component	actin filament bundle
C	0042802	molecular_function	identical protein binding
C	0044297	cellular_component	cell body
C	0048306	molecular_function	calcium-dependent protein binding
C	0048741	biological_process	skeletal muscle fiber development
C	0051017	biological_process	actin filament bundle assembly
C	0090131	biological_process	mesenchyme migration
C	0098723	cellular_component	skeletal muscle myofibril
C	0140660	molecular_function	cytoskeletal motor activator activity
D	0000775	cellular_component	chromosome, centromeric region
D	0000776	cellular_component	kinetochore
D	0000781	cellular_component	chromosome, telomeric region
D	0001824	biological_process	blastocyst development
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0005515	molecular_function	protein binding
D	0005521	molecular_function	lamin binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005815	cellular_component	microtubule organizing center
D	0005856	cellular_component	cytoskeleton
D	0005977	biological_process	glycogen metabolic process
D	0006338	biological_process	chromatin remodeling
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006470	biological_process	protein dephosphorylation
D	0007283	biological_process	spermatogenesis
D	0008157	molecular_function	protein phosphatase 1 binding
D	0016607	cellular_component	nuclear speck
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0017018	molecular_function	myosin phosphatase activity
D	0019901	molecular_function	protein kinase binding
D	0019903	molecular_function	protein phosphatase binding
D	0019904	molecular_function	protein domain specific binding
D	0030182	biological_process	neuron differentiation
D	0030496	cellular_component	midbody
D	0032154	cellular_component	cleavage furrow
D	0032922	biological_process	circadian regulation of gene expression
D	0032991	cellular_component	protein-containing complex
D	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
D	0042752	biological_process	regulation of circadian rhythm
D	0043153	biological_process	entrainment of circadian clock by photoperiod
D	0043197	cellular_component	dendritic spine
D	0044877	molecular_function	protein-containing complex binding
D	0046822	biological_process	regulation of nucleocytoplasmic transport
D	0046872	molecular_function	metal ion binding
D	0048511	biological_process	rhythmic process
D	0051301	biological_process	cell division
D	0060252	biological_process	positive regulation of glial cell proliferation
D	0072357	cellular_component	PTW/PP1 phosphatase complex
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0140791	molecular_function	histone H2AXS140 phosphatase activity
D	0180004	molecular_function	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
D	0180005	molecular_function	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
D	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
D	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
D	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
D	1990439	molecular_function	MAP kinase serine/threonine phosphatase activity
F	0000775	cellular_component	chromosome, centromeric region
F	0000776	cellular_component	kinetochore
F	0000781	cellular_component	chromosome, telomeric region
F	0001824	biological_process	blastocyst development
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0004722	molecular_function	protein serine/threonine phosphatase activity
F	0005515	molecular_function	protein binding
F	0005521	molecular_function	lamin binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005815	cellular_component	microtubule organizing center
F	0005856	cellular_component	cytoskeleton
F	0005977	biological_process	glycogen metabolic process
F	0006338	biological_process	chromatin remodeling
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006470	biological_process	protein dephosphorylation
F	0007283	biological_process	spermatogenesis
F	0008157	molecular_function	protein phosphatase 1 binding
F	0016607	cellular_component	nuclear speck
F	0016787	molecular_function	hydrolase activity
F	0016791	molecular_function	phosphatase activity
F	0017018	molecular_function	myosin phosphatase activity
F	0019901	molecular_function	protein kinase binding
F	0019903	molecular_function	protein phosphatase binding
F	0019904	molecular_function	protein domain specific binding
F	0030182	biological_process	neuron differentiation
F	0030496	cellular_component	midbody
F	0032154	cellular_component	cleavage furrow
F	0032922	biological_process	circadian regulation of gene expression
F	0032991	cellular_component	protein-containing complex
F	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
F	0042752	biological_process	regulation of circadian rhythm
F	0043153	biological_process	entrainment of circadian clock by photoperiod
F	0043197	cellular_component	dendritic spine
F	0044877	molecular_function	protein-containing complex binding
F	0046822	biological_process	regulation of nucleocytoplasmic transport
F	0046872	molecular_function	metal ion binding
F	0048511	biological_process	rhythmic process
F	0051301	biological_process	cell division
F	0060252	biological_process	positive regulation of glial cell proliferation
F	0072357	cellular_component	PTW/PP1 phosphatase complex
F	0098793	cellular_component	presynapse
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0140791	molecular_function	histone H2AXS140 phosphatase activity
F	0180004	molecular_function	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
F	0180005	molecular_function	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
F	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
F	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
F	1990439	molecular_function	MAP kinase serine/threonine phosphatase activity
H	0000775	cellular_component	chromosome, centromeric region
H	0000776	cellular_component	kinetochore
H	0000781	cellular_component	chromosome, telomeric region
H	0001824	biological_process	blastocyst development
H	0004721	molecular_function	phosphoprotein phosphatase activity
H	0004722	molecular_function	protein serine/threonine phosphatase activity
H	0005515	molecular_function	protein binding
H	0005521	molecular_function	lamin binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005815	cellular_component	microtubule organizing center
H	0005856	cellular_component	cytoskeleton
H	0005977	biological_process	glycogen metabolic process
H	0006338	biological_process	chromatin remodeling
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006470	biological_process	protein dephosphorylation
H	0007283	biological_process	spermatogenesis
H	0008157	molecular_function	protein phosphatase 1 binding
H	0016607	cellular_component	nuclear speck
H	0016787	molecular_function	hydrolase activity
H	0016791	molecular_function	phosphatase activity
H	0017018	molecular_function	myosin phosphatase activity
H	0019901	molecular_function	protein kinase binding
H	0019903	molecular_function	protein phosphatase binding
H	0019904	molecular_function	protein domain specific binding
H	0030182	biological_process	neuron differentiation
H	0030496	cellular_component	midbody
H	0032154	cellular_component	cleavage furrow
H	0032922	biological_process	circadian regulation of gene expression
H	0032991	cellular_component	protein-containing complex
H	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
H	0042752	biological_process	regulation of circadian rhythm
H	0043153	biological_process	entrainment of circadian clock by photoperiod
H	0043197	cellular_component	dendritic spine
H	0044877	molecular_function	protein-containing complex binding
H	0046822	biological_process	regulation of nucleocytoplasmic transport
H	0046872	molecular_function	metal ion binding
H	0048511	biological_process	rhythmic process
H	0051301	biological_process	cell division
H	0060252	biological_process	positive regulation of glial cell proliferation
H	0072357	cellular_component	PTW/PP1 phosphatase complex
H	0098793	cellular_component	presynapse
H	0098794	cellular_component	postsynapse
H	0098978	cellular_component	glutamatergic synapse
H	0140791	molecular_function	histone H2AXS140 phosphatase activity
H	0180004	molecular_function	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
H	0180005	molecular_function	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
H	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
H	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
H	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
H	1990439	molecular_function	MAP kinase serine/threonine phosphatase activity
J	0000775	cellular_component	chromosome, centromeric region
J	0000776	cellular_component	kinetochore
J	0000781	cellular_component	chromosome, telomeric region
J	0001824	biological_process	blastocyst development
J	0004721	molecular_function	phosphoprotein phosphatase activity
J	0004722	molecular_function	protein serine/threonine phosphatase activity
J	0005515	molecular_function	protein binding
J	0005521	molecular_function	lamin binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0005815	cellular_component	microtubule organizing center
J	0005856	cellular_component	cytoskeleton
J	0005977	biological_process	glycogen metabolic process
J	0006338	biological_process	chromatin remodeling
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006470	biological_process	protein dephosphorylation
J	0007283	biological_process	spermatogenesis
J	0008157	molecular_function	protein phosphatase 1 binding
J	0016607	cellular_component	nuclear speck
J	0016787	molecular_function	hydrolase activity
J	0016791	molecular_function	phosphatase activity
J	0017018	molecular_function	myosin phosphatase activity
J	0019901	molecular_function	protein kinase binding
J	0019903	molecular_function	protein phosphatase binding
J	0019904	molecular_function	protein domain specific binding
J	0030182	biological_process	neuron differentiation
J	0030496	cellular_component	midbody
J	0032154	cellular_component	cleavage furrow
J	0032922	biological_process	circadian regulation of gene expression
J	0032991	cellular_component	protein-containing complex
J	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
J	0042752	biological_process	regulation of circadian rhythm
J	0043153	biological_process	entrainment of circadian clock by photoperiod
J	0043197	cellular_component	dendritic spine
J	0044877	molecular_function	protein-containing complex binding
J	0046822	biological_process	regulation of nucleocytoplasmic transport
J	0046872	molecular_function	metal ion binding
J	0048511	biological_process	rhythmic process
J	0051301	biological_process	cell division
J	0060252	biological_process	positive regulation of glial cell proliferation
J	0072357	cellular_component	PTW/PP1 phosphatase complex
J	0098793	cellular_component	presynapse
J	0098794	cellular_component	postsynapse
J	0098978	cellular_component	glutamatergic synapse
J	0140791	molecular_function	histone H2AXS140 phosphatase activity
J	0180004	molecular_function	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
J	0180005	molecular_function	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
J	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
J	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
J	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
J	1990439	molecular_function	MAP kinase serine/threonine phosphatase activity
L	0000287	molecular_function	magnesium ion binding
L	0001725	cellular_component	stress fiber
L	0003785	molecular_function	actin monomer binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005523	molecular_function	tropomyosin binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005865	cellular_component	striated muscle thin filament
L	0005884	cellular_component	actin filament
L	0010628	biological_process	positive regulation of gene expression
L	0016787	molecular_function	hydrolase activity
L	0019904	molecular_function	protein domain specific binding
L	0030027	cellular_component	lamellipodium
L	0030041	biological_process	actin filament polymerization
L	0030175	cellular_component	filopodium
L	0030240	biological_process	skeletal muscle thin filament assembly
L	0031013	molecular_function	troponin I binding
L	0031432	molecular_function	titin binding
L	0031941	cellular_component	filamentous actin
L	0032036	molecular_function	myosin heavy chain binding
L	0032432	cellular_component	actin filament bundle
L	0042802	molecular_function	identical protein binding
L	0044297	cellular_component	cell body
L	0048306	molecular_function	calcium-dependent protein binding
L	0048741	biological_process	skeletal muscle fiber development
L	0051017	biological_process	actin filament bundle assembly
L	0090131	biological_process	mesenchyme migration
L	0098723	cellular_component	skeletal muscle myofibril
L	0140660	molecular_function	cytoskeletal motor activator activity
M	0000287	molecular_function	magnesium ion binding
M	0001725	cellular_component	stress fiber
M	0003785	molecular_function	actin monomer binding
M	0005509	molecular_function	calcium ion binding
M	0005515	molecular_function	protein binding
M	0005523	molecular_function	tropomyosin binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005865	cellular_component	striated muscle thin filament
M	0005884	cellular_component	actin filament
M	0010628	biological_process	positive regulation of gene expression
M	0016787	molecular_function	hydrolase activity
M	0019904	molecular_function	protein domain specific binding
M	0030027	cellular_component	lamellipodium
M	0030041	biological_process	actin filament polymerization
M	0030175	cellular_component	filopodium
M	0030240	biological_process	skeletal muscle thin filament assembly
M	0031013	molecular_function	troponin I binding
M	0031432	molecular_function	titin binding
M	0031941	cellular_component	filamentous actin
M	0032036	molecular_function	myosin heavy chain binding
M	0032432	cellular_component	actin filament bundle
M	0042802	molecular_function	identical protein binding
M	0044297	cellular_component	cell body
M	0048306	molecular_function	calcium-dependent protein binding
M	0048741	biological_process	skeletal muscle fiber development
M	0051017	biological_process	actin filament bundle assembly
M	0090131	biological_process	mesenchyme migration
M	0098723	cellular_component	skeletal muscle myofibril
M	0140660	molecular_function	cytoskeletal motor activator activity
N	0000775	cellular_component	chromosome, centromeric region
N	0000776	cellular_component	kinetochore
N	0000781	cellular_component	chromosome, telomeric region
N	0001824	biological_process	blastocyst development
N	0004721	molecular_function	phosphoprotein phosphatase activity
N	0004722	molecular_function	protein serine/threonine phosphatase activity
N	0005515	molecular_function	protein binding
N	0005521	molecular_function	lamin binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005741	cellular_component	mitochondrial outer membrane
N	0005815	cellular_component	microtubule organizing center
N	0005856	cellular_component	cytoskeleton
N	0005977	biological_process	glycogen metabolic process
N	0006338	biological_process	chromatin remodeling
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006470	biological_process	protein dephosphorylation
N	0007283	biological_process	spermatogenesis
N	0008157	molecular_function	protein phosphatase 1 binding
N	0016607	cellular_component	nuclear speck
N	0016787	molecular_function	hydrolase activity
N	0016791	molecular_function	phosphatase activity
N	0017018	molecular_function	myosin phosphatase activity
N	0019901	molecular_function	protein kinase binding
N	0019903	molecular_function	protein phosphatase binding
N	0019904	molecular_function	protein domain specific binding
N	0030182	biological_process	neuron differentiation
N	0030496	cellular_component	midbody
N	0032154	cellular_component	cleavage furrow
N	0032922	biological_process	circadian regulation of gene expression
N	0032991	cellular_component	protein-containing complex
N	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
N	0042752	biological_process	regulation of circadian rhythm
N	0043153	biological_process	entrainment of circadian clock by photoperiod
N	0043197	cellular_component	dendritic spine
N	0044877	molecular_function	protein-containing complex binding
N	0046822	biological_process	regulation of nucleocytoplasmic transport
N	0046872	molecular_function	metal ion binding
N	0048511	biological_process	rhythmic process
N	0051301	biological_process	cell division
N	0060252	biological_process	positive regulation of glial cell proliferation
N	0072357	cellular_component	PTW/PP1 phosphatase complex
N	0098793	cellular_component	presynapse
N	0098794	cellular_component	postsynapse
N	0098978	cellular_component	glutamatergic synapse
N	0140791	molecular_function	histone H2AXS140 phosphatase activity
N	0180004	molecular_function	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
N	0180005	molecular_function	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
N	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
N	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
N	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
N	1990439	molecular_function	MAP kinase serine/threonine phosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LAB A 1376

Chain	Residue
A	GLY15
A	GLU207
A	ARG210
A	LYS213
A	LEU16
A	ILE34
A	GLN59
A	TYR69
A	ASP157
A	ARG183
A	THR186
A	ARG206

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP A 1377

Chain	Residue
A	GLY13
A	SER14
A	GLY15
A	LEU16
A	LYS18
A	GLY74
A	GLY156
A	ASP157
A	GLY158
A	VAL159
A	GLY182
A	ARG210
A	LYS213
A	GLU214
A	GLY301
A	GLY302
A	THR303
A	MET305
A	TYR306
A	LYS336

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LAB B 1376

Chain	Residue
B	GLY15
B	LEU16
B	ILE34
B	GLN59
B	TYR69
B	ASP157
B	ARG183
B	THR186
B	ARG206
B	GLU207
B	ARG210

---

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP B 1377

Chain	Residue
B	GLY13
B	SER14
B	GLY15
B	LEU16
B	LYS18
B	GLY74
B	GLY156
B	ASP157
B	GLY158
B	VAL159
B	GLY182
B	ARG210
B	LYS213
B	GLU214
B	GLY301
B	GLY302
B	THR303
B	MET305
B	TYR306
B	LYS336

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LAB C 1376

Chain	Residue
C	GLY15
C	LEU16
C	ILE34
C	GLN59
C	TYR69
C	ASP157
C	ARG183
C	THR186
C	ARG206
C	GLU207
C	ARG210
C	LYS213

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP C 1377

Chain	Residue
C	GLY13
C	SER14
C	GLY15
C	LEU16
C	LYS18
C	GLY74
C	GLY156
C	ASP157
C	GLY158
C	VAL159
C	GLY182
C	ARG210
C	LYS213
C	GLU214
C	GLY301
C	GLY302
C	THR303
C	MET305
C	TYR306
C	LYS336

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN D 1301

Chain	Residue
D	ASP64
D	HIS66
D	ASP92
D	MN1302

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN D 1302

Chain	Residue
D	ASP92
D	ASN124
D	HIS173
D	HIS248
D	MN1301

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN F 1301

Chain	Residue
F	ASP64
F	HIS66
F	ASP92
F	MN1302

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN F 1302

Chain	Residue
F	ASP92
F	ASN124
F	HIS173
F	HIS248
F	MN1301

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN H 1301

Chain	Residue
H	ASP64
H	HIS66
H	ASP92
H	MN1302

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN H 1302

Chain	Residue
H	ASP92
H	ASN124
H	HIS173
H	HIS248
H	MN1301

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN J 1301

Chain	Residue
J	ASP64
J	HIS66
J	ASP92
J	MN1302

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN J 1302

Chain	Residue
J	ASP92
J	ASN124
J	HIS173
J	HIS248
J	MN1301

---

site_id	BC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LAB L 1376

Chain	Residue
L	GLY15
L	LEU16
L	ILE34
L	GLN59
L	TYR69
L	ASP157
L	ARG183
L	THR186
L	ARG206
L	GLU207
L	ARG210

---

site_id	BC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP L 1377

Chain	Residue
L	GLY13
L	SER14
L	GLY15
L	LEU16
L	LYS18
L	GLY74
L	GLY156
L	ASP157
L	GLY158
L	VAL159
L	GLY182
L	ARG210
L	LYS213
L	GLU214
L	GLY301
L	GLY302
L	THR303
L	MET305
L	TYR306
L	LYS336

---

site_id	BC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LAB M 1376

Chain	Residue
M	GLY15
M	LEU16
M	ILE34
M	GLN59
M	TYR69
M	ASP157
M	ARG183
M	THR186
M	ARG206
M	GLU207
M	ARG210

---

site_id	BC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP M 1377

Chain	Residue
M	GLY13
M	SER14
M	GLY15
M	LEU16
M	LYS18
M	GLY74
M	GLY156
M	ASP157
M	GLY158
M	VAL159
M	GLY182
M	ARG210
M	LYS213
M	GLU214
M	GLY301
M	GLY302
M	THR303
M	MET305
M	TYR306
M	LYS336

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN N 1301

Chain	Residue
N	ASP64
N	HIS66
N	ASP92
N	MN1302

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN N 1302

Chain	Residue
N	ASP92
N	ASN124
N	HIS173
N	HIS248
N	MN1301

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
D	LEU121-GLU126

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
D	HIS125
F	HIS125
H	HIS125
J	HIS125
N	HIS125

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
D	ASP64
F	ASN124
F	HIS173
F	HIS248
H	ASP64
H	HIS66
H	ASP92
H	ASN124
H	HIS173
H	HIS248
J	ASP64
D	HIS66
J	HIS66
J	ASP92
J	ASN124
J	HIS173
J	HIS248
N	ASP64
N	HIS66
N	ASP92
N	ASN124
N	HIS173
D	ASP92
N	HIS248
D	ASN124
D	HIS173
D	HIS248
F	ASP64
F	HIS66
F	ASP92

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P36873

Chain	Residue	Details
D	ALA2
F	ALA2
H	ALA2
J	ALA2
N	ALA2

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P36873

Chain	Residue	Details
D	THR307
N	THR311
D	THR311
F	THR307
F	THR311
H	THR307
H	THR311
J	THR307
J	THR311
N	THR307

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68133

Chain	Residue	Details
A	LYS84
B	LYS84
C	LYS84
L	LYS84
M	LYS84

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	MOD_RES: ADP-ribosylarginine; by SpvB => ECO:0000305|PubMed:16905096

Chain	Residue	Details
A	ARG177
B	ARG177
C	ARG177
L	ARG177
M	ARG177

---