Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4UXD

2-keto 3-deoxygluconate aldolase from Picrophilus torridus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006007	biological_process	glucose catabolic process
A	0008674	molecular_function	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
A	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
A	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009436	biological_process	glyoxylate catabolic process
A	0016829	molecular_function	lyase activity
A	0016832	molecular_function	aldehyde-lyase activity
A	0044281	biological_process	small molecule metabolic process
A	0061677	molecular_function	2-dehydro-3-deoxy-D-gluconate aldolase activity
B	0005829	cellular_component	cytosol
B	0006007	biological_process	glucose catabolic process
B	0008674	molecular_function	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
B	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
B	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0009436	biological_process	glyoxylate catabolic process
B	0016829	molecular_function	lyase activity
B	0016832	molecular_function	aldehyde-lyase activity
B	0044281	biological_process	small molecule metabolic process
B	0061677	molecular_function	2-dehydro-3-deoxy-D-gluconate aldolase activity
C	0005829	cellular_component	cytosol
C	0006007	biological_process	glucose catabolic process
C	0008674	molecular_function	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
C	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
C	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009436	biological_process	glyoxylate catabolic process
C	0016829	molecular_function	lyase activity
C	0016832	molecular_function	aldehyde-lyase activity
C	0044281	biological_process	small molecule metabolic process
C	0061677	molecular_function	2-dehydro-3-deoxy-D-gluconate aldolase activity
D	0005829	cellular_component	cytosol
D	0006007	biological_process	glucose catabolic process
D	0008674	molecular_function	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
D	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
D	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009436	biological_process	glyoxylate catabolic process
D	0016829	molecular_function	lyase activity
D	0016832	molecular_function	aldehyde-lyase activity
D	0044281	biological_process	small molecule metabolic process
D	0061677	molecular_function	2-dehydro-3-deoxy-D-gluconate aldolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1275

Chain	Residue
A	PRO8
A	PHE40
A	SER44
A	THR45
A	TYR131
A	SER161
A	VAL201
A	GOL1276

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1276

Chain	Residue
A	GLY184
A	GLN185
A	ASP186
A	VAL201
A	CYS202
A	GLY203
A	TYR249
A	GOL1275
A	IPA1277
A	THR45

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IPA A 1277

Chain	Residue
A	GLN135
A	PHE136
A	GLN185
A	PHE245
A	GOL1276

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 1275

Chain	Residue
B	PRO8
B	GLY43
B	SER44
B	THR45
B	TYR131
B	LYS159
B	GLY184
B	VAL201
B	GOL1276

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 1276

Chain	Residue
B	THR45
B	GLY184
B	ASP186
B	VAL201
B	CYS202
B	GLY203
B	MET237
B	TYR249
B	GOL1275
B	IPA1277

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA B 1277

Chain	Residue
B	GLN135
B	GLN185
B	GOL1276

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL C 1275

Chain	Residue
C	PRO8
C	PHE40
C	GLY43
C	SER44
C	THR45
C	TYR131
C	SER161
C	GLY184
C	VAL201
C	EDO1276
C	PGE1277

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO C 1276

Chain	Residue
C	GLY184
C	ASP186
C	VAL201
C	CYS202
C	GLY203
C	MET237
C	TYR249
C	GOL1275
C	PGE1277

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE C 1277

Chain	Residue
C	ILE133
C	PHE136
C	GLN185
C	PHE245
C	GOL1275
C	EDO1276

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL D 1275

Chain	Residue
D	PRO8
D	PHE40
D	GLY43
D	SER44
D	THR45
D	TYR131
D	SER161
D	GLY184
D	EDO1276
D	GOL1277

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO D 1276

Chain	Residue
D	GLY184
D	ASP186
D	VAL201
D	CYS202
D	GLY203
D	MET237
D	TYR249
D	GOL1275
D	GOL1277

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 1277

Chain	Residue
A	HOH2075
D	SER161
D	GLN185
D	PHE245
D	GOL1275
D	EDO1276

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1278

Chain	Residue
A	ASP14
A	ASN18
A	HOH2010

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 1278

Chain	Residue
A	GOL1281
D	ASP187
D	ILE234
D	LYS238

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 1279

Chain	Residue
D	ILE19
D	ASP20
D	TYR21
D	ASN22

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 1280

Chain	Residue
C	ASN81
C	HOH2038
D	HIS16
D	GLY17
D	ASN18
D	ARG264
D	HOH2006

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 1278

Chain	Residue
B	ARG166
B	MET169
B	GLU170
C	ASP187
C	ILE234
C	LYS238

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 1279

Chain	Residue
C	ASN109
C	GLN110
C	LYS139
C	HOH2052

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1278

Chain	Residue
B	ASN109
B	GLN110
B	LYS139
B	ASP141

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1279

Chain	Residue
A	ASN109
A	GLN110
A	LYS139

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 1281

Chain	Residue
D	LYS107
D	ASN109
D	GLN110
D	LYS139
D	HOH2048

site_id	CC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 1279

Chain	Residue
A	TYR105
A	GLN135
A	PHE136
A	GOL1280
B	TYR104
B	TYR105
B	PHE136
B	THR137
B	ASN138

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1280

Chain	Residue
A	TYR104
A	TYR105
A	LYS107
A	PHE136
A	THR137
A	ASN138
B	GLN135
B	PHE136
B	GOL1279

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1280

Chain	Residue
B	ASP141
B	PRO142
B	GLY167
B	GLU170
B	MET171

site_id	CC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 1282

Chain	Residue
C	GLN135
C	PHE136
C	HOH2048
D	TYR104
D	TYR105
D	PHE136
D	THR137
D	ASN138

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1281

Chain	Residue
A	ARG166
A	MET169
A	GLU170
D	ILE234
D	EDO1278

site_id	CC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 1282

Chain	Residue
A	ASN132
A	ILE140
A	ASP141
A	PRO142
A	GLY167
A	MET171
A	HOH2061
A	HOH2067
A	HOH2069
A	HOH2076
A	HOH2091

site_id	DC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PEG B 1281

Chain	Residue
B	ASP164
B	ARG166
B	HOH2052
B	HOH2054
B	HOH2073
B	HOH2074
C	SER162
C	ALA163
C	ASP164

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IPA D 1283

Chain	Residue
D	LYS107
D	PRO134
D	THR137
D	LYS139

Functional Information from PROSITE/UniProt

site_id	PS00666
Number of Residues	31
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YNIPqfTnk.IdpetvknlksefssVkGVKDS

Chain	Residue	Details
A	TYR131-SER161

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000250

Chain	Residue	Details
A	LYS159
B	LYS159
C	LYS159
D	LYS159

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	TYR131
B	LYS159
C	SER44
C	TYR131
C	LYS159
D	SER44
D	TYR131
D	LYS159
A	SER44
A	TYR131
A	LYS159
B	SER44

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Proton shuttle => ECO:0000250

Chain	Residue	Details
A	TYR131
B	TYR131
C	TYR131
D	TYR131

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)