4UTW

Structural characterisation of NanE, ManNac6P C2 epimerase, from Clostridium perfingens

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006051	biological_process	N-acetylmannosamine metabolic process
A	0006053	biological_process	N-acetylmannosamine catabolic process
A	0016853	molecular_function	isomerase activity
A	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
A	0019262	biological_process	N-acetylneuraminate catabolic process
A	0047465	molecular_function	N-acylglucosamine-6-phosphate 2-epimerase activity
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006051	biological_process	N-acetylmannosamine metabolic process
B	0006053	biological_process	N-acetylmannosamine catabolic process
B	0016853	molecular_function	isomerase activity
B	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
B	0019262	biological_process	N-acetylneuraminate catabolic process
B	0047465	molecular_function	N-acylglucosamine-6-phosphate 2-epimerase activity
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006051	biological_process	N-acetylmannosamine metabolic process
C	0006053	biological_process	N-acetylmannosamine catabolic process
C	0016853	molecular_function	isomerase activity
C	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
C	0019262	biological_process	N-acetylneuraminate catabolic process
C	0047465	molecular_function	N-acylglucosamine-6-phosphate 2-epimerase activity
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006051	biological_process	N-acetylmannosamine metabolic process
D	0006053	biological_process	N-acetylmannosamine catabolic process
D	0016853	molecular_function	isomerase activity
D	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
D	0019262	biological_process	N-acetylneuraminate catabolic process
D	0047465	molecular_function	N-acylglucosamine-6-phosphate 2-epimerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1221

Chain	Residue
A	ARG208
A	PRO209
A	GLN210
A	HOH2069
A	HOH2070

---

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE RFW A 1222

Chain	Residue
A	TYR75
A	THR147
A	TYR151
A	GLU180
A	ARG182
A	GLY203
A	GLY204
A	ARG208
A	HOH2007
A	HOH2051
A	HOH2052
A	HOH2133
A	HOH2214
A	HOH2219
A	HOH2254
A	HOH2255
A	HOH2278
A	HOH2282
A	GLN14
A	ARG43
A	ILE64
A	LYS66

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 1221

Chain	Residue
B	ARG208
B	PRO209
B	GLN210
B	HOH2060
B	HOH2061

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE RFW B 1222

Chain	Residue
B	GLN14
B	ARG43
B	ILE64
B	LYS66
B	TYR75
B	THR147
B	TYR151
B	GLU180
B	ARG182
B	GLY203
B	GLY204
B	ARG208
B	HOH2006
B	HOH2048
B	HOH2049
B	HOH2196
B	HOH2200
B	HOH2230
B	HOH2231
B	HOH2247
B	HOH2251
B	HOH2265
B	HOH2266

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 1221

Chain	Residue
C	ARG208
C	PRO209
C	GLN210
C	HOH2050
C	HOH2051

---

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE RFW C 1222

Chain	Residue
C	GLN14
C	ARG43
C	ILE64
C	LYS66
C	TYR75
C	ILE76
C	TYR151
C	GLU180
C	GLY181
C	ARG182
C	GLY203
C	GLY204
C	ARG208
C	HOH2036
C	HOH2039
C	HOH2169
C	HOH2173
C	HOH2199
C	HOH2200
C	HOH2213
C	HOH2232

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 1221

Chain	Residue
D	ARG208
D	PRO209
D	GLN210
D	HOH2044

---

site_id	AC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE RFW D 1222

Chain	Residue
D	HOH2147
D	HOH2153
D	HOH2171
D	HOH2172
D	HOH2188
D	HOH2193
D	GLN14
D	ARG43
D	ILE64
D	LYS66
D	TYR75
D	THR147
D	TYR151
D	GLU180
D	ARG182
D	GLY203
D	GLY204
D	ARG208
D	HOH2030
D	HOH2033

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