4UIS

The cryoEM structure of human gamma-Secretase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0016485	biological_process	protein processing
B	0016020	cellular_component	membrane
B	0016485	biological_process	protein processing
B	0042500	molecular_function	aspartic endopeptidase activity, intramembrane cleaving
G	0003796	molecular_function	lysozyme activity
G	0003824	molecular_function	catalytic activity
G	0009253	biological_process	peptidoglycan catabolic process
G	0016787	molecular_function	hydrolase activity
G	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
G	0016998	biological_process	cell wall macromolecule catabolic process
G	0030430	cellular_component	host cell cytoplasm
G	0031640	biological_process	killing of cells of another organism
G	0042742	biological_process	defense response to bacterium
G	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VAATrlDsRSFAWNV

Chain	Residue	Details
A	VAL277-VAL291

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26280335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30630874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26280335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30630874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26280335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30630874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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