4U3J
TOG2:alpha/beta-tubulin complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000070 | biological_process | mitotic sister chromatid segregation |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0000280 | biological_process | nuclear division |
| A | 0003674 | molecular_function | molecular_function |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005819 | cellular_component | spindle |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0007010 | biological_process | cytoskeleton organization |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0030473 | biological_process | nuclear migration along microtubule |
| A | 0034399 | cellular_component | nuclear periphery |
| A | 0045143 | biological_process | homologous chromosome segregation |
| A | 0045298 | cellular_component | tubulin complex |
| A | 0098863 | biological_process | nuclear migration by microtubule mediated pushing forces |
| B | 0000022 | biological_process | mitotic spindle elongation |
| B | 0000070 | biological_process | mitotic sister chromatid segregation |
| B | 0000226 | biological_process | microtubule cytoskeleton organization |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007010 | biological_process | cytoskeleton organization |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0007052 | biological_process | mitotic spindle organization |
| B | 0031122 | biological_process | cytoplasmic microtubule organization |
| B | 0045298 | cellular_component | tubulin complex |
| B | 0090307 | biological_process | mitotic spindle assembly |
| B | 0090316 | biological_process | positive regulation of intracellular protein transport |
| B | 0097435 | biological_process | supramolecular fiber organization |
| C | 0007051 | biological_process | spindle organization |
| C | 0015631 | molecular_function | tubulin binding |
| C | 0030951 | biological_process | establishment or maintenance of microtubule cytoskeleton polarity |
| C | 0046785 | biological_process | microtubule polymerization |
| C | 0051010 | molecular_function | microtubule plus-end binding |
| C | 0061863 | molecular_function | microtubule plus end polymerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 501 |
| Chain | Residue |
| A | GLN11 |
| A | GLU72 |
| A | GTP502 |
| A | HOH604 |
| A | HOH606 |
| A | HOH607 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for residue GTP A 502 |
| Chain | Residue |
| A | GLN15 |
| A | ALA101 |
| A | ASN102 |
| A | SER141 |
| A | GLY144 |
| A | GLY145 |
| A | THR146 |
| A | GLY147 |
| A | VAL178 |
| A | THR180 |
| A | GLU184 |
| A | ASN207 |
| A | PHE225 |
| A | ASN229 |
| A | ILE232 |
| A | MG501 |
| A | HOH604 |
| A | HOH606 |
| A | HOH607 |
| A | HOH609 |
| B | LYS252 |
| A | GLY10 |
| A | GLN11 |
| A | ALA12 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 501 |
| Chain | Residue |
| B | GTP502 |
| B | HOH608 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue GTP B 502 |
| Chain | Residue |
| B | GLY10 |
| B | GLN11 |
| B | CYS12 |
| B | GLN15 |
| B | ALA97 |
| B | ASN99 |
| B | SER138 |
| B | GLY141 |
| B | GLY142 |
| B | THR143 |
| B | GLY144 |
| B | GLU181 |
| B | ASN204 |
| B | TYR222 |
| B | ASN226 |
| B | MG501 |
| B | HOH608 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"11739794","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00103","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 224 |
| Details | Region: {"description":"TOG 1","evidences":[{"source":"PubMed","id":"16567500","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
