4U2R

Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 B 301

Chain	Residue
B	THR91
B	ARG96
B	GLY141
B	SER142
B	HOH537
B	HOH755
B	HOH756
B	HOH814

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site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 D 301

Chain	Residue
D	ARG96
D	SER142
D	HOH533
D	HOH649
D	HOH771
D	THR91

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
B	PRO89
A	SER142
A	THR143
A	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
D	PRO89
B	THR91
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
B	ARG96
B	SER142
B	THR143
B	GLU193
A	PRO89
A	THR91
A	ARG96

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site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG64
D	ARG64
D	ARG148
D	LYS240
B	ARG148
B	LYS240
A	ARG64
A	ARG148
A	LYS240
C	ARG64
C	ARG148
C	LYS240

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE121
A	ILE121
C	ILE121
D	ILE121

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER150
A	SER150
C	SER150
D	SER150

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER184
A	SER184
C	SER184
D	SER184

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN3
A	ASN3
C	ASN3
D	ASN3

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