4U0M

Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D193N in complex with ATP, GTP and 5MTHFGLU2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0009117	biological_process	nucleotide metabolic process
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0009405	biological_process	obsolete pathogenesis
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0046872	molecular_function	metal ion binding
A	0050922	biological_process	negative regulation of chemotaxis
A	0051607	biological_process	defense response to virus
A	0052621	molecular_function	diguanylate cyclase activity
A	0140701	molecular_function	3',3'-cyclic GMP-AMP synthase activity
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0009117	biological_process	nucleotide metabolic process
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0009405	biological_process	obsolete pathogenesis
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0046872	molecular_function	metal ion binding
B	0050922	biological_process	negative regulation of chemotaxis
B	0051607	biological_process	defense response to virus
B	0052621	molecular_function	diguanylate cyclase activity
B	0140701	molecular_function	3',3'-cyclic GMP-AMP synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue GTP A 501

Chain	Residue
A	GLN112
A	ASP348
A	LEU352
A	ATP502
A	MG503
A	HOH656
A	HOH681
A	HOH685
A	HOH689
A	HOH692
A	HOH699
A	GLY113
A	HOH720
A	HOH763
A	HOH774
A	SER114
A	TYR117
A	ASP131
A	ASP133
A	VAL264
A	LYS287
A	SER301

---

site_id	AC2
Number of Residues	9
Details	binding site for residue ATP A 502

Chain	Residue
A	GLN112
A	ASP133
A	LYS177
A	THR179
A	ARG182
A	ASN193
A	LEU247
A	SER259
A	GTP501

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 503

Chain	Residue
A	ASP131
A	ASP133
A	GTP501
A	HOH763

---

site_id	AC4
Number of Residues	18
Details	binding site for residue TLL A 504

Chain	Residue
A	ARG36
A	ARG40
A	ARG44
A	ARG108
A	PHE109
A	TRP110
A	THR111
A	GLN116
A	TYR137
A	PHE204
A	GLN208
A	GLU239
A	LEU240
A	ASP260
A	PRO261
A	LYS262
A	HOH760
A	HOH787

---

site_id	AC5
Number of Residues	25
Details	binding site for residue GTP B 501

Chain	Residue
B	GLN112
B	GLY113
B	SER114
B	TYR117
B	ASP131
B	ASP133
B	VAL264
B	LYS287
B	SER301
B	ASP345
B	ASP348
B	LEU352
B	ATP502
B	MG503
B	HOH649
B	HOH668
B	HOH678
B	HOH685
B	HOH708
B	HOH724
B	HOH730
B	HOH739
B	HOH765
B	HOH766
B	HOH778

---

site_id	AC6
Number of Residues	15
Details	binding site for residue ATP B 502

Chain	Residue
B	ASP131
B	ASP133
B	LYS177
B	THR179
B	ARG182
B	HIS191
B	ASN193
B	SER259
B	GTP501
B	HOH695
B	HOH702
B	HOH708
B	HOH739
B	HOH762
B	HOH776

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MG B 503

Chain	Residue
B	ASP131
B	ASP133
B	GTP501
B	HOH724

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TY0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---