4U03
Structure of the vibrio cholerae di-nucleotide cyclase (DncV) in complex with GTP and 5MTHFGLU2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| A | 0009405 | biological_process | obsolete pathogenesis |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050922 | biological_process | negative regulation of chemotaxis |
| A | 0051607 | biological_process | defense response to virus |
| A | 0052621 | molecular_function | diguanylate cyclase activity |
| A | 0140701 | molecular_function | 3',3'-cyclic GMP-AMP synthase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| B | 0009405 | biological_process | obsolete pathogenesis |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050922 | biological_process | negative regulation of chemotaxis |
| B | 0051607 | biological_process | defense response to virus |
| B | 0052621 | molecular_function | diguanylate cyclase activity |
| B | 0140701 | molecular_function | 3',3'-cyclic GMP-AMP synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue GTP A 501 |
| Chain | Residue |
| A | GLN112 |
| A | ASP348 |
| A | LEU352 |
| A | GTP502 |
| A | MG503 |
| A | HOH643 |
| A | HOH658 |
| A | HOH663 |
| A | HOH665 |
| A | HOH680 |
| A | HOH691 |
| A | GLY113 |
| A | HOH742 |
| A | HOH748 |
| A | HOH757 |
| A | SER114 |
| A | TYR117 |
| A | ASP131 |
| A | ASP133 |
| A | LYS287 |
| A | SER301 |
| A | ASP345 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue GTP A 502 |
| Chain | Residue |
| A | GLN112 |
| A | ASP131 |
| A | ASP133 |
| A | LYS177 |
| A | THR179 |
| A | CYS180 |
| A | ARG182 |
| A | ASP193 |
| A | TYR197 |
| A | LEU247 |
| A | SER259 |
| A | GTP501 |
| A | MG504 |
| A | HOH757 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | ASP131 |
| A | ASP133 |
| A | GTP501 |
| A | HOH750 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 504 |
| Chain | Residue |
| A | ASP131 |
| A | ASP133 |
| A | ASP193 |
| A | GTP502 |
| A | HOH757 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue TLL A 505 |
| Chain | Residue |
| A | ARG36 |
| A | ARG40 |
| A | ARG44 |
| A | ARG108 |
| A | PHE109 |
| A | TRP110 |
| A | THR111 |
| A | GLN116 |
| A | TYR137 |
| A | PHE204 |
| A | GLN208 |
| A | TYR238 |
| A | GLU239 |
| A | LEU240 |
| A | ASP260 |
| A | PRO261 |
| A | LYS262 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | binding site for residue GTP B 501 |
| Chain | Residue |
| B | GLN112 |
| B | GLY113 |
| B | SER114 |
| B | TYR117 |
| B | ASP131 |
| B | ASP133 |
| B | LYS287 |
| B | ARG290 |
| B | SER301 |
| B | ASP345 |
| B | ASP348 |
| B | LEU352 |
| B | GTP502 |
| B | MG503 |
| B | HOH630 |
| B | HOH633 |
| B | HOH688 |
| B | HOH689 |
| B | HOH691 |
| B | HOH692 |
| B | HOH700 |
| B | HOH706 |
| B | HOH714 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue GTP B 502 |
| Chain | Residue |
| B | GLN112 |
| B | ASP133 |
| B | LYS177 |
| B | THR179 |
| B | CYS180 |
| B | ARG182 |
| B | ASP193 |
| B | TYR197 |
| B | SER259 |
| B | GTP501 |
| B | MG504 |
| B | HOH653 |
| B | HOH665 |
| B | HOH714 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 503 |
| Chain | Residue |
| B | ASP131 |
| B | ASP133 |
| B | GTP501 |
| B | HOH710 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 504 |
| Chain | Residue |
| B | ASP131 |
| B | ASP133 |
| B | ASP193 |
| B | GTP502 |
| B | HOH714 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for residue TLL B 505 |
| Chain | Residue |
| B | ARG36 |
| B | ARG40 |
| B | ARG108 |
| B | PHE109 |
| B | TRP110 |
| B | THR111 |
| B | GLN116 |
| B | TYR137 |
| B | PHE204 |
| B | TYR238 |
| B | GLU239 |
| B | LEU240 |
| B | SER242 |
| B | ASP260 |
| B | PRO261 |
| B | LYS262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TY0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
