Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for "syn-HEA type inhibitor |
| Chain | Residue |
| B | GLY72 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR293 |
| B | ASN294 |
| B | ARG296 |
| E | HOH101 |
| B | GLN73 |
| B | ASP93 |
| B | TYR132 |
| B | THR133 |
| B | GLN134 |
| B | PHE169 |
| B | ILE171 |
| B | TYR259 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for "syn-HEA type inhibitor |
| Chain | Residue |
| B | GLY72 |
| B | GLN73 |
| B | ASP93 |
| B | TYR132 |
| B | THR133 |
| B | GLN134 |
| B | PHE169 |
| B | ILE171 |
| B | TYR259 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR293 |
| B | ASN294 |
| B | ARG296 |
| E | HOH101 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for "syn-HEA type inhibitor |
| Chain | Residue |
| B | GLY72 |
| B | GLN73 |
| B | ASP93 |
| B | TYR132 |
| B | THR133 |
| B | GLN134 |
| B | PHE169 |
| B | ILE171 |
| B | TYR259 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR293 |
| B | ASN294 |
| B | ARG296 |
| E | HOH101 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for "syn-HEA type inhibitor |
| Chain | Residue |
| B | GLY72 |
| B | GLN73 |
| B | ASP93 |
| B | TYR132 |
| B | THR133 |
| B | GLN134 |
| B | PHE169 |
| B | ILE171 |
| B | TYR259 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR293 |
| B | ASN294 |
| B | ARG296 |
| E | HOH101 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for "syn-HEA type inhibitor |
| Chain | Residue |
| B | GLY72 |
| B | GLN73 |
| B | ASP93 |
| B | TYR132 |
| B | THR133 |
| B | GLN134 |
| B | PHE169 |
| B | ILE171 |
| B | TYR259 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR293 |
| B | ASN294 |
| B | ARG296 |
| E | HOH101 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for "syn-HEA type inhibitor |
| Chain | Residue |
| B | GLY72 |
| B | GLN73 |
| B | ASP93 |
| B | TYR132 |
| B | THR133 |
| B | GLN134 |
| B | PHE169 |
| B | ILE171 |
| B | TYR259 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR293 |
| B | ASN294 |
| B | ARG296 |
| E | HOH101 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | |
| Chain | Residue |
| C | TYR132 |
| C | THR133 |
| C | GLN134 |
| C | PHE169 |
| C | ILE171 |
| C | TYR259 |
| C | ASP289 |
| C | GLY291 |
| C | THR292 |
| C | THR293 |
| C | ASN294 |
| C | ARG296 |
| F | HOH101 |
| C | SER71 |
| C | GLY72 |
| C | ASP93 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | |
| Chain | Residue |
| A | GLY72 |
| A | GLN73 |
| A | GLY74 |
| A | ASP93 |
| A | TYR132 |
| A | THR133 |
| A | GLN134 |
| A | PHE169 |
| A | TYR259 |
| A | ILE287 |
| A | ASP289 |
| A | GLY291 |
| A | THR292 |
| A | THR293 |
| A | ASN294 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE90-VAL101 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP93 | |
| A | ASP289 | |
| B | ASP93 | |
| B | ASP289 | |
| C | ASP93 | |
| C | ASP289 | |
| Chain | Residue | Details |
| A | LYS126 | |
| B | LYS279 | |
| B | LYS285 | |
| B | LYS299 | |
| B | LYS300 | |
| B | LYS307 | |
| C | LYS126 | |
| C | LYS275 | |
| C | LYS279 | |
| C | LYS285 | |
| C | LYS299 | |
| A | LYS275 | |
| C | LYS300 | |
| C | LYS307 | |
| A | LYS279 | |
| A | LYS285 | |
| A | LYS299 | |
| A | LYS300 | |
| A | LYS307 | |
| B | LYS126 | |
| B | LYS275 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN153 | |
| C | ASN172 | |
| C | ASN223 | |
| C | ASN354 | |
| A | ASN172 | |
| A | ASN223 | |
| A | ASN354 | |
| B | ASN153 | |
| B | ASN172 | |
| B | ASN223 | |
| B | ASN354 | |
| C | ASN153 | |
