4TR9
Ternary co-crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP and a small molecule inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003779 | molecular_function | actin binding |
A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006096 | biological_process | glycolytic process |
A | 0008154 | biological_process | actin polymerization or depolymerization |
A | 0016020 | cellular_component | membrane |
A | 0016829 | molecular_function | lyase activity |
A | 0020002 | cellular_component | host cell plasma membrane |
A | 0051289 | biological_process | protein homotetramerization |
B | 0003779 | molecular_function | actin binding |
B | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006096 | biological_process | glycolytic process |
B | 0008154 | biological_process | actin polymerization or depolymerization |
B | 0016020 | cellular_component | membrane |
B | 0016829 | molecular_function | lyase activity |
B | 0020002 | cellular_component | host cell plasma membrane |
B | 0051289 | biological_process | protein homotetramerization |
C | 0003779 | molecular_function | actin binding |
C | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006096 | biological_process | glycolytic process |
C | 0008154 | biological_process | actin polymerization or depolymerization |
C | 0016020 | cellular_component | membrane |
C | 0016829 | molecular_function | lyase activity |
C | 0020002 | cellular_component | host cell plasma membrane |
C | 0051289 | biological_process | protein homotetramerization |
D | 0003779 | molecular_function | actin binding |
D | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006096 | biological_process | glycolytic process |
D | 0008154 | biological_process | actin polymerization or depolymerization |
D | 0016020 | cellular_component | membrane |
D | 0016829 | molecular_function | lyase activity |
D | 0020002 | cellular_component | host cell plasma membrane |
D | 0051289 | biological_process | protein homotetramerization |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue 38D A 401 |
Chain | Residue |
A | ASP39 |
A | HOH618 |
H | ASP604 |
H | ASN606 |
A | THR44 |
A | LYS151 |
A | ARG153 |
A | GLU194 |
A | LYS236 |
A | HOH525 |
A | HOH527 |
A | HOH564 |
site_id | AC2 |
Number of Residues | 13 |
Details | binding site for residue 38D B 401 |
Chain | Residue |
B | ASP39 |
B | SER41 |
B | THR44 |
B | LYS47 |
B | LYS112 |
B | LYS151 |
B | ARG153 |
B | HOH502 |
B | HOH569 |
B | HOH594 |
I | ASP604 |
I | ASN606 |
I | HOH702 |
site_id | AC3 |
Number of Residues | 13 |
Details | binding site for residue 38D C 401 |
Chain | Residue |
C | ASP39 |
C | THR44 |
C | LYS47 |
C | LYS112 |
C | LYS151 |
C | HOH510 |
C | HOH533 |
C | HOH555 |
C | HOH560 |
C | HOH574 |
C | HOH599 |
C | HOH614 |
J | ASN606 |
site_id | AC4 |
Number of Residues | 10 |
Details | binding site for residue 38D K 701 |
Chain | Residue |
D | ASP39 |
D | THR44 |
D | ARG48 |
D | LYS112 |
D | LYS151 |
D | ARG153 |
K | ASP604 |
K | TRP605 |
K | ASN606 |
K | HOH801 |
Functional Information from PROSITE/UniProt
site_id | PS00158 |
Number of Residues | 11 |
Details | ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VlLEGaLLKPN |
Chain | Residue | Details |
A | VAL228-ASN238 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P00883 |
Chain | Residue | Details |
A | GLU194 | |
B | GLU194 | |
C | GLU194 | |
D | GLU194 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Schiff-base intermediate with dihydroxyacetone-P => ECO:0000250|UniProtKB:P00883 |
Chain | Residue | Details |
A | LYS236 | |
B | LYS236 | |
C | LYS236 | |
D | LYS236 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00883 |
Chain | Residue | Details |
C | SER278 | |
C | SER306 | |
C | ARG309 | |
D | ARG48 | |
D | SER278 | |
D | SER306 | |
D | ARG309 | |
C | ARG48 | |
A | ARG48 | |
A | SER278 | |
A | SER306 | |
A | ARG309 | |
B | ARG48 | |
B | SER278 | |
B | SER306 | |
B | ARG309 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | SITE: Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate => ECO:0000250|UniProtKB:P00883 |
Chain | Residue | Details |
A | TYR368 | |
B | TYR368 | |
C | TYR368 | |
D | TYR368 |