4TR2

Crystal structure of PvSUB1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 801

Chain	Residue
A	ASP281
A	ASP325
A	VAL383
A	ASN386
A	ILE388
A	ILE390

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 802

Chain	Residue
A	PRO135
A	GLY190
A	GLU129
A	ASN130
A	THR133

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 803

Chain	Residue
A	GLU336
A	ASP344
A	ASP346
A	ASN348
A	VAL350
A	ASP353

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CA A 804

Chain	Residue
A	GLU336
A	ARG340
A	VAL343
A	ASP345
A	ASP352

---

site_id	AC5
Number of Residues	5
Details	binding site for residue PO4 A 805

Chain	Residue
A	ASP438
A	GLU439
A	TYR440
A	HIS484
A	TYR486

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PO4 A 806

Chain	Residue
A	ASN303
A	GLY384
A	ASN385
A	HIS396

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PO4 A 807

Chain	Residue
A	GLU129
A	HIS131
A	SER136
A	GLU139

---

site_id	AC8
Number of Residues	6
Details	binding site for residue CA B 801

Chain	Residue
B	ASP281
B	ASP325
B	VAL383
B	ASN386
B	ILE388
B	ILE390

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CA B 802

Chain	Residue
B	GLU129
B	ASN130
B	THR133
B	PRO135
B	GLY190

---

site_id	AD1
Number of Residues	6
Details	binding site for residue CA B 803

Chain	Residue
B	GLU336
B	ASP344
B	ASP346
B	ASN348
B	VAL350
B	ASP353

---

site_id	AD2
Number of Residues	6
Details	binding site for residue CA B 804

Chain	Residue
B	GLU336
B	ARG340
B	VAL343
B	ASP345
B	ASP352
B	HOH903

---

site_id	AD3
Number of Residues	5
Details	binding site for residue PO4 B 805

Chain	Residue
B	ASP438
B	GLU439
B	TYR440
B	HIS484
B	TYR486

---

site_id	AD4
Number of Residues	5
Details	binding site for residue PO4 B 806

Chain	Residue
A	ARG452
B	GLU129
B	HIS131
B	SER136
B	GLU139

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. ICVIDSGIdynH

Chain	Residue	Details
A	ILE312-HIS323

---

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVSGiISA

Chain	Residue	Details
A	HIS372-ALA382

---

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAsPhVAA

Chain	Residue	Details
A	GLY547-ALA557

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	634
Details	Domain: {"description":"Peptidase S8","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25204226","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TR2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25204226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37428845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38503166","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8COY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8COZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QKG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25204226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37428845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38503166","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8COY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8COZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QKG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Cleavage","evidences":[{"source":"PubMed","id":"37428845","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"37428845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38503166","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8COY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8COZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QKG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---