4TMA

Crystal structure of gyrase bound to its inhibitor YacG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change
E	0003677	molecular_function	DNA binding
E	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
E	0005524	molecular_function	ATP binding
E	0006259	biological_process	DNA metabolic process
E	0006265	biological_process	DNA topological change
F	0003677	molecular_function	DNA binding
F	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
F	0005524	molecular_function	ATP binding
F	0006265	biological_process	DNA topological change
G	0003677	molecular_function	DNA binding
G	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
G	0005524	molecular_function	ATP binding
G	0006259	biological_process	DNA metabolic process
G	0006265	biological_process	DNA topological change
H	0003677	molecular_function	DNA binding
H	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
H	0005524	molecular_function	ATP binding
H	0006265	biological_process	DNA topological change
I	0005515	molecular_function	protein binding
I	0006355	biological_process	regulation of DNA-templated transcription
I	0008270	molecular_function	zinc ion binding
I	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
I	0046872	molecular_function	metal ion binding
J	0005515	molecular_function	protein binding
J	0006355	biological_process	regulation of DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
J	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
J	0046872	molecular_function	metal ion binding
K	0005515	molecular_function	protein binding
K	0006355	biological_process	regulation of DNA-templated transcription
K	0008270	molecular_function	zinc ion binding
K	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
K	0046872	molecular_function	metal ion binding
L	0005515	molecular_function	protein binding
L	0006355	biological_process	regulation of DNA-templated transcription
L	0008270	molecular_function	zinc ion binding
L	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN B 1001

Chain	Residue
B	ASP500
B	VAL501
B	ASP502

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN E 601

Chain	Residue
E	TYR321
E	SER322
E	THR324
E	GLN327

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN I 101

Chain	Residue
I	CYS28
I	CYS32
I	CYS9
I	CYS12

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site_id	AC4
Number of Residues	4
Details	binding site for residue ZN J 101

Chain	Residue
J	CYS9
J	CYS12
J	CYS28
J	CYS32

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN K 101

Chain	Residue
K	CYS9
K	CYS12
K	CYS28
K	CYS32

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN L 101

Chain	Residue
L	CYS9
L	CYS12
L	CYS28
L	CYS32

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Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU422-GLY430

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING:

Chain	Residue	Details
I	CYS9
K	CYS12
K	CYS28
K	CYS32
L	CYS9
L	CYS12
L	CYS28
L	CYS32
I	CYS12
I	CYS28
I	CYS32
J	CYS9
J	CYS12
J	CYS28
J	CYS32
K	CYS9

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