4RXD
T. Brucei Farnesyl Diphosphate Synthase Complexed with Risedronate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| C | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1401 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | MG1403 |
| A | RIS1404 |
| A | HOH1642 |
| A | HOH1653 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1402 |
| Chain | Residue |
| A | HOH1644 |
| A | HOH1652 |
| A | ASP255 |
| A | RIS1404 |
| A | HOH1643 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 1403 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | MG1401 |
| A | RIS1404 |
| A | HOH1501 |
| A | HOH1641 |
| A | HOH1654 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE RIS A 1404 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | ARG112 |
| A | GLN172 |
| A | LYS212 |
| A | THR213 |
| A | ASP255 |
| A | LYS269 |
| A | MG1401 |
| A | MG1402 |
| A | MG1403 |
| A | HOH1534 |
| A | HOH1545 |
| A | HOH1571 |
| A | HOH1641 |
| A | HOH1642 |
| A | HOH1643 |
| A | HOH1644 |
| A | HOH1652 |
| A | HOH1653 |
| A | HOH1654 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1501 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | MG1503 |
| B | RIS1504 |
| B | HOH1747 |
| B | HOH1752 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1502 |
| Chain | Residue |
| B | ASP255 |
| B | ASP259 |
| B | RIS1504 |
| B | HOH1604 |
| B | HOH1745 |
| B | HOH1753 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 1503 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | MG1501 |
| B | RIS1504 |
| B | HOH1624 |
| B | HOH1746 |
| B | HOH1751 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE RIS B 1504 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | ARG112 |
| B | GLN172 |
| B | LYS212 |
| B | THR213 |
| B | ASP255 |
| B | LYS269 |
| B | MG1501 |
| B | MG1502 |
| B | MG1503 |
| B | HOH1604 |
| B | HOH1624 |
| B | HOH1641 |
| B | HOH1712 |
| B | HOH1745 |
| B | HOH1746 |
| B | HOH1747 |
| B | HOH1748 |
| B | HOH1749 |
| B | HOH1752 |
| B | HOH1753 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE RIS C 1600 |
| Chain | Residue |
| C | HOH1845 |
| C | HOH1849 |
| C | HOH1851 |
| C | ASP103 |
| C | ASP107 |
| C | ARG112 |
| C | GLN172 |
| C | LYS212 |
| C | THR213 |
| C | ASP255 |
| C | LYS269 |
| C | MG1601 |
| C | MG1602 |
| C | MG1603 |
| C | HOH1715 |
| C | HOH1732 |
| C | HOH1797 |
| C | HOH1803 |
| C | HOH1841 |
| C | HOH1842 |
| C | HOH1843 |
| C | HOH1844 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 1601 |
| Chain | Residue |
| C | ASP103 |
| C | ASP107 |
| C | RIS1600 |
| C | MG1603 |
| C | HOH1842 |
| C | HOH1849 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 1602 |
| Chain | Residue |
| C | ASP255 |
| C | RIS1600 |
| C | HOH1715 |
| C | HOH1843 |
| C | HOH1851 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG C 1603 |
| Chain | Residue |
| C | ASP103 |
| C | ASP107 |
| C | RIS1600 |
| C | MG1601 |
| C | HOH1732 |
| C | HOH1841 |
| C | HOH1850 |
Functional Information from PROSITE/UniProt
