4RMF

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004815	molecular_function	aspartate-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006422	biological_process	aspartyl-tRNA aminoacylation
A	0016874	molecular_function	ligase activity
A	0050560	molecular_function	aspartate-tRNA(Asn) ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 3SY A 701

Chain	Residue
A	MET447
A	HIS448
A	ASP475
A	GLU482
A	GLY485

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FMT A 702

Chain	Residue
A	GLY485
A	GLY486
A	ARG489
A	ILE531
A	ALA532
A	GLN194
A	LYS197
A	HIS448
A	HIS449

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Region: {"description":"Aspartate","evidences":[{"source":"HAMAP-Rule","id":"MF_00044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Important for tRNA non-discrimination","evidences":[{"source":"HAMAP-Rule","id":"MF_00044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---