4RKZ
Crystal Structure of Mevalonate-3-Kinase from Thermoplasma acidophilum (Mevalonate 3-Phosphate/ADP Bound)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADP A 401 |
| Chain | Residue |
| A | SER48 |
| A | GLY111 |
| A | ARG185 |
| A | SER188 |
| A | 3S4402 |
| A | PHE62 |
| A | TYR96 |
| A | SER98 |
| A | ASN100 |
| A | SER105 |
| A | GLY106 |
| A | SER107 |
| A | SER108 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 3S4 A 402 |
| Chain | Residue |
| A | GLY15 |
| A | LEU18 |
| A | LEU19 |
| A | SER105 |
| A | GLU140 |
| A | ARG144 |
| A | ARG185 |
| A | HIS192 |
| A | THR275 |
| A | GLY276 |
| A | ADP401 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | TYR183 |
| A | GLN184 |
| A | ARG251 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 3S4 B 401 |
| Chain | Residue |
| B | LEU18 |
| B | LEU19 |
| B | SER105 |
| B | GLU140 |
| B | ARG144 |
| B | ARG185 |
| B | THR275 |
| B | GLY276 |
| B | SO4404 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 402 |
| Chain | Residue |
| B | ARG251 |
| B | GLU252 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 403 |
| Chain | Residue |
| B | TYR183 |
| B | GLN184 |
| B | ARG251 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 404 |
| Chain | Residue |
| B | LEU104 |
| B | SER105 |
| B | GLY106 |
| B | SER107 |
| B | SER108 |
| B | ARG185 |
| B | 3S4401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25422158, ECO:0007744|PDB:4RKS |
| Chain | Residue | Details |
| A | LEU19 | |
| A | ARG144 | |
| B | LEU19 | |
| B | GLU140 | |
| B | ARG144 | |
| A | GLU140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25422158, ECO:0007744|PDB:4RKZ |
| Chain | Residue | Details |
| B | TYR96 | |
| B | ARG185 | |
| A | TYR96 | |
| A | ARG185 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25422158, ECO:0007744|PDB:4RKP, ECO:0007744|PDB:4RKZ |
| Chain | Residue | Details |
| B | SER105 | |
| B | SER188 | |
| A | SER105 | |
| A | SER188 |
