4RDQ

Calcium-activated chloride channel bestrophin-1, from chicken, in complex with Fab antibody fragments, chloride and calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005254	molecular_function	chloride channel activity
B	0005254	molecular_function	chloride channel activity
C	0005254	molecular_function	chloride channel activity
D	0005254	molecular_function	chloride channel activity
E	0005254	molecular_function	chloride channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 501

Chain	Residue
A	ALA146
A	GLY299
A	ASP301
A	PHE305
A	GLU306
A	THR307
A	ASN308
E	ARG356

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 502

Chain	Residue
A	THR277
B	TYR68
B	TYR72
A	PRO274

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 503

Chain	Residue
A	GLU74
A	LEU75
A	ILE76

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 504

Chain	Residue
A	GLN293
A	ASN296
A	ASP301
A	ASP304
E	ALA10
E	HOH602

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 505

Chain	Residue
A	SER219

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 506

Chain	Residue
A	GLU35
A	TYR245
A	GLU292
E	LEU14
E	SER18

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE C6N A 507

Chain	Residue
A	ARG8
A	ASP11
A	ARG13
A	GLY15
A	THR16
A	GLN19
I	GLU57

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 501

Chain	Residue
A	ARG356
B	ALA146
B	GLY299
B	ASP301
B	ASP304
B	PHE305
B	GLU306
B	THR307
B	ASN308

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 502

Chain	Residue
A	ALA10
A	HOH602
B	GLN293
B	ASN296
B	ASP301
B	ASP304

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 503

Chain	Residue
B	SER219

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 504

Chain	Residue
B	PRO274
B	THR277
C	TYR68
C	TYR72

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 505

Chain	Residue
B	GLU74
B	LEU75
B	ILE76

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K B 506

Chain	Residue
A	LEU14
A	SER18
B	GLU35
B	TYR245
B	GLU292

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE C6N B 507

Chain	Residue
B	ARG8
B	ASP11
B	ARG13
B	GLY15
B	THR16
B	GLN19
K	GLU57

---

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 501

Chain	Residue
B	ARG356
C	ALA146
C	GLY299
C	ASP301
C	PHE305
C	GLU306
C	THR307
C	ASN308

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 502

Chain	Residue
B	ALA10
B	HOH602
C	GLN293
C	ASN296
C	ASP301
C	ASP304

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 503

Chain	Residue
C	SER219

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 504

Chain	Residue
C	PRO274
C	THR277
D	TYR68
D	TYR72

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 505

Chain	Residue
C	GLU74
C	LEU75
C	ILE76

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 506

Chain	Residue
B	LEU14
B	SER18
C	GLU35
C	TYR245
C	GLU292

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 507

Chain	Residue
D	TYR245
D	GLU292
C	LEU14
C	SER18
D	GLU35

---

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE C6N C 508

Chain	Residue
C	ARG8
C	ASP11
C	ARG13
C	GLY15
C	THR16
C	GLN19
M	GLU57

---

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 501

Chain	Residue
C	ARG356
D	ALA146
D	GLY299
D	ASP301
D	ASP304
D	PHE305
D	GLU306
D	THR307
D	ASN308

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 502

Chain	Residue
C	ALA10
C	HOH602
D	GLN293
D	ASN296
D	ASP301
D	ASP304

---

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 503

Chain	Residue
D	SER219

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 504

Chain	Residue
D	PRO274
D	THR277
E	TYR68
E	TYR72

---

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 505

Chain	Residue
D	GLU74
D	LEU75
D	ILE76

---

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE C6N D 506

Chain	Residue
D	ARG8
D	ASP11
D	ARG13
D	GLY15
D	THR16
D	GLN19
O	GLU57

---

site_id	DC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL E 501

Chain	Residue
D	ARG356
E	ALA146
E	GLY299
E	ASP301
E	ASP304
E	PHE305
E	GLU306
E	THR307
E	ASN308

---

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 502

Chain	Residue
D	ALA10
D	HOH602
E	GLN293
E	ASN296
E	ASP301
E	ASP304

---

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 503

Chain	Residue
E	SER219

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 504

Chain	Residue
A	TYR68
A	TYR72
E	PRO274
E	THR277

---

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 505

Chain	Residue
E	GLU74
E	LEU75
E	ILE76

---

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 506

Chain	Residue
D	LEU14
D	SER18
E	GLU35
E	TYR245
E	GLU292

---

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE C6N E 507

Chain	Residue
E	ARG8
E	ASP11
E	ARG13
E	GLY15
E	THR16
E	GLN19

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
F	TYR192-HIS198

---