Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4QWT

Anaerobic crystal structure of delta413-417:GS LOX in complex with arachidonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0034440	biological_process	lipid oxidation
A	0046872	molecular_function	metal ion binding
B	0005506	molecular_function	iron ion binding
B	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B	0034440	biological_process	lipid oxidation
B	0046872	molecular_function	metal ion binding
C	0005506	molecular_function	iron ion binding
C	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
C	0034440	biological_process	lipid oxidation
C	0046872	molecular_function	metal ion binding
D	0005506	molecular_function	iron ion binding
D	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
D	0034440	biological_process	lipid oxidation
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 A 701

Chain	Residue
A	HIS384
A	HIS389
A	HIS570
A	ASN574
A	ILE693
A	HOH1352

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 702

Chain	Residue
A	ASP81
A	HOH877
A	HIS17
A	GLY19
A	ASP79

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 703

Chain	Residue
A	GLU51
A	HOH802
A	HOH806
A	HOH846
B	ASN655
B	HOH801
B	HOH803

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 704

Chain	Residue
A	PHE232
A	GLN235
A	PHE236
A	GLU375
A	ASN586

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 705

Chain	Residue
A	HIS161
A	SER175
A	GLN179

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 706

Chain	Residue
A	ASN263
A	ALA264
A	LEU266
A	HOH1349

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 707

Chain	Residue
A	TYR636
A	ARG686

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 708

Chain	Residue
A	LEU189
A	SER193
A	THR196
A	ALA618
A	HOH1248

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 709

Chain	Residue
A	ASN263
A	LEU266
A	ASP267
A	ARG268
A	GLY269
A	LYS270
A	ASN271
A	HOH1310

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 710

Chain	Residue
A	GLY503
A	ILE506
A	ALA507
A	GLU553
A	LYS556
A	HOH966

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 711

Chain	Residue
A	VAL288
A	PHE378
A	ASN382
A	ARG387
A	CYS456

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 712

Chain	Residue
A	VAL243
A	ASP464
A	LEU467
A	TYR487
A	HOH848
A	HOH1040
A	HOH1311

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 713

Chain	Residue
A	ALA117
A	GLU646
A	ASP647

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 714

Chain	Residue
A	THR35
A	ASP36
A	GLY57
A	PHE58

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 715

Chain	Residue
A	ASN655
A	HOH801
A	HOH813
B	GLU51
B	HOH802
B	HOH805
B	HOH821

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 716

Chain	Residue
A	GLU199
A	ASN200
A	ASP202
A	ASP206

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 717

Chain	Residue
A	SER441
A	TYR581
A	ALA589
A	ALA620
A	VAL624

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 718

Chain	Residue
A	ASP490
A	LYS667
A	HOH895

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT A 719

Chain	Residue
A	HIS227

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 720

Chain	Residue
A	GLY19
A	THR20
A	HOH1186

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 B 701

Chain	Residue
B	HIS384
B	HIS389
B	HIS570
B	ASN574
B	ILE693
B	HOH1150

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 702

Chain	Residue
B	HIS17
B	GLY19
B	ASP79
B	ASP81
B	HOH1093

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 703

Chain	Residue
B	PHE232
B	GLN235
B	PHE236
B	GLU375
B	ASN586

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT B 704

Chain	Residue
B	PHE630
B	TYR636

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT B 705

Chain	Residue
B	LEU189
B	GLY192
B	SER193
B	THR196
B	LEU210
B	ALA618

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT B 706

Chain	Residue
B	SER175
B	GLN179

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 707

Chain	Residue
B	GLY503
B	ILE506
B	ALA507
B	GLU553
B	LYS556
B	HOH906
B	HOH1028

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 708

Chain	Residue
B	PHE378
B	ASN382
B	ARG387
B	CYS456
B	GLU459

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 709

Chain	Residue
B	ALA117
B	TRP645
B	GLU646
B	ASP647

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 710

Chain	Residue
A	ASP659
A	GLU662
B	ALA22
B	ASP41
B	GLY43
B	HOH993
B	HOH1138

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 711

Chain	Residue
B	GLU199
B	ASN200
B	ASP202
B	SER203
B	ASP206

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 712

Chain	Residue
A	ASP21
A	ASP41
A	GLY43
B	ASP659
B	GLU662
B	HOH1130

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 C 701

Chain	Residue
C	HIS384
C	HIS389
C	HIS570
C	ASN574
C	ILE693
C	HOH815

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 702

Chain	Residue
C	HIS17
C	GLY19
C	ASP79
C	ASP81
C	HOH931

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 703

Chain	Residue
C	GLU51
C	HOH801
C	HOH807
C	HOH1301
D	ASN655
D	HOH808
D	HOH1176

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 704

Chain	Residue
C	PHE232
C	GLN235
C	PHE236
C	GLU375
C	ASN586

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT C 705

Chain	Residue
C	HIS161
C	SER175
C	GLN179

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT C 706

Chain	Residue
C	PHE630
C	TYR636
C	GLU685

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT C 707

Chain	Residue
C	LEU189
C	GLY192
C	SER193
C	THR196
C	LYS614
C	ALA618
C	HOH1014

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 708

Chain	Residue
C	ASP205
C	HIS208
C	ALA223
C	TRP226
C	HIS227
C	HOH1143

site_id	EC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 709

Chain	Residue
C	GLY503
C	ILE506
C	ALA507
C	GLU553
C	LYS556
C	HOH1127

site_id	EC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 710

Chain	Residue
C	ALA22
C	ASP41
C	GLY43
C	HOH1042
C	HOH1282
C	HOH1300
D	ASP659
D	GLU662

site_id	EC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 711

Chain	Residue
B	LYS517
B	GLN523
B	SER548
B	PHE549
C	LEU251
C	SER253
C	HOH884
C	HOH972
C	HOH995

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 712

Chain	Residue
C	ALA117
C	TRP645
C	GLU646
C	ASP647

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 713

Chain	Residue
C	THR35
C	ASP36
C	PHE58

site_id	FC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 714

Chain	Residue
C	ASN655
C	HOH818
D	GLU51
D	HOH803
D	HOH804
D	HOH805
D	HOH827

site_id	FC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ACD C 715

Chain	Residue
C	TYR178
C	ARG182
C	GLN380
C	HIS384
C	LEU385
C	HIS389
C	GLY427
C	LEU431
C	ILE437
C	SER441
C	LEU627
C	HOH1209

site_id	FC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 716

Chain	Residue
C	ASP659
C	GLU662
C	HOH1189
C	HOH1289
D	ALA22
D	ASP41
D	GLY43

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 717

Chain	Residue
C	ASN200
C	TRP201
C	ASP202
C	ASP206

site_id	FC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT C 718

Chain	Residue
C	ASP490

site_id	FC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 701

Chain	Residue
D	PHE232
D	GLN235
D	GLU375
D	ASN586

site_id	FC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 D 702

Chain	Residue
D	HIS384
D	HIS389
D	HIS570
D	ASN574
D	ILE693
D	HOH819

site_id	FC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 703

Chain	Residue
D	HIS17
D	GLY19
D	ASP79
D	ASP81
D	HOH823

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 704

Chain	Residue
D	LEU189
D	SER193
D	THR196
D	ALA618

site_id	GC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT D 705

Chain	Residue
D	ASP205
D	ALA223
D	TRP226

site_id	GC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 706

Chain	Residue
D	GLY503
D	ALA507
D	GLU553
D	LYS556
D	HOH900

site_id	GC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 707

Chain	Residue
D	ALA117
D	LYS411
D	TRP645
D	GLU646
D	ASP647

site_id	GC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 708

Chain	Residue
D	ASN200
D	ASP202
D	SER203
D	ASP206

site_id	GC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT D 709

Chain	Residue
D	PHE630
D	TYR636
D	GLU685

site_id	GC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT D 710

Chain	Residue
D	GLN380
D	SER441
D	ALA589
D	ALA620
D	VAL624

site_id	GC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT D 711

Chain	Residue
D	GLY19
D	THR20
D	GLU46

Functional Information from PROSITE/UniProt

site_id	PS00081
Number of Residues	11
Details	LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. AHPIfKLLqPH

Chain	Residue	Details
A	ALA406-HIS416

site_id	PS00711
Number of Residues	15
Details	LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HQlntHlLRTHLTtE

Chain	Residue	Details
A	HIS379-GLU393

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16162493","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 758

Chain

Residue

Details

site_id	MCSA2
Number of Residues
Details	M-CSA 758

Chain

Residue

Details

site_id	MCSA3
Number of Residues
Details	M-CSA 758

Chain

Residue

Details

site_id	MCSA4
Number of Residues
Details	M-CSA 758

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)