Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| A | 0034440 | biological_process | lipid oxidation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| B | 0034440 | biological_process | lipid oxidation |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| C | 0034440 | biological_process | lipid oxidation |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| D | 0034440 | biological_process | lipid oxidation |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 A 701 |
| Chain | Residue |
| A | HIS384 |
| A | HIS389 |
| A | HIS570 |
| A | ASN574 |
| A | ILE693 |
| A | HOH1352 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 702 |
| Chain | Residue |
| A | ASP81 |
| A | HOH877 |
| A | HIS17 |
| A | GLY19 |
| A | ASP79 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 703 |
| Chain | Residue |
| A | GLU51 |
| A | HOH802 |
| A | HOH806 |
| A | HOH846 |
| B | ASN655 |
| B | HOH801 |
| B | HOH803 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 704 |
| Chain | Residue |
| A | PHE232 |
| A | GLN235 |
| A | PHE236 |
| A | GLU375 |
| A | ASN586 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 705 |
| Chain | Residue |
| A | HIS161 |
| A | SER175 |
| A | GLN179 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 706 |
| Chain | Residue |
| A | ASN263 |
| A | ALA264 |
| A | LEU266 |
| A | HOH1349 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 707 |
| Chain | Residue |
| A | TYR636 |
| A | ARG686 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 708 |
| Chain | Residue |
| A | LEU189 |
| A | SER193 |
| A | THR196 |
| A | ALA618 |
| A | HOH1248 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 709 |
| Chain | Residue |
| A | ASN263 |
| A | LEU266 |
| A | ASP267 |
| A | ARG268 |
| A | GLY269 |
| A | LYS270 |
| A | ASN271 |
| A | HOH1310 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 710 |
| Chain | Residue |
| A | GLY503 |
| A | ILE506 |
| A | ALA507 |
| A | GLU553 |
| A | LYS556 |
| A | HOH966 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 711 |
| Chain | Residue |
| A | VAL288 |
| A | PHE378 |
| A | ASN382 |
| A | ARG387 |
| A | CYS456 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 712 |
| Chain | Residue |
| A | VAL243 |
| A | ASP464 |
| A | LEU467 |
| A | TYR487 |
| A | HOH848 |
| A | HOH1040 |
| A | HOH1311 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 713 |
| Chain | Residue |
| A | ALA117 |
| A | GLU646 |
| A | ASP647 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 714 |
| Chain | Residue |
| A | THR35 |
| A | ASP36 |
| A | GLY57 |
| A | PHE58 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 715 |
| Chain | Residue |
| A | ASN655 |
| A | HOH801 |
| A | HOH813 |
| B | GLU51 |
| B | HOH802 |
| B | HOH805 |
| B | HOH821 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 716 |
| Chain | Residue |
| A | GLU199 |
| A | ASN200 |
| A | ASP202 |
| A | ASP206 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 717 |
| Chain | Residue |
| A | SER441 |
| A | TYR581 |
| A | ALA589 |
| A | ALA620 |
| A | VAL624 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 718 |
| Chain | Residue |
| A | ASP490 |
| A | LYS667 |
| A | HOH895 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT A 719 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 720 |
| Chain | Residue |
| A | GLY19 |
| A | THR20 |
| A | HOH1186 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 B 701 |
| Chain | Residue |
| B | HIS384 |
| B | HIS389 |
| B | HIS570 |
| B | ASN574 |
| B | ILE693 |
| B | HOH1150 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 702 |
| Chain | Residue |
| B | HIS17 |
| B | GLY19 |
| B | ASP79 |
| B | ASP81 |
| B | HOH1093 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 703 |
| Chain | Residue |
| B | PHE232 |
| B | GLN235 |
| B | PHE236 |
| B | GLU375 |
| B | ASN586 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 704 |
| Chain | Residue |
| B | PHE630 |
| B | TYR636 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 705 |
| Chain | Residue |
| B | LEU189 |
| B | GLY192 |
| B | SER193 |
| B | THR196 |
| B | LEU210 |
| B | ALA618 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 706 |
| Chain | Residue |
| B | SER175 |
| B | GLN179 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 707 |
| Chain | Residue |
| B | GLY503 |
| B | ILE506 |
| B | ALA507 |
| B | GLU553 |
| B | LYS556 |
| B | HOH906 |
| B | HOH1028 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 708 |
| Chain | Residue |
| B | PHE378 |
| B | ASN382 |
| B | ARG387 |
| B | CYS456 |
| B | GLU459 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 709 |
| Chain | Residue |
| B | ALA117 |
| B | TRP645 |
| B | GLU646 |
| B | ASP647 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 710 |
| Chain | Residue |
| A | ASP659 |
| A | GLU662 |
| B | ALA22 |
| B | ASP41 |
| B | GLY43 |
| B | HOH993 |
| B | HOH1138 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 711 |
| Chain | Residue |
| B | GLU199 |
| B | ASN200 |
| B | ASP202 |
| B | SER203 |
| B | ASP206 |
| site_id | DC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 712 |
| Chain | Residue |
| A | ASP21 |
| A | ASP41 |
| A | GLY43 |
| B | ASP659 |
| B | GLU662 |
| B | HOH1130 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 C 701 |
| Chain | Residue |
| C | HIS384 |
| C | HIS389 |
| C | HIS570 |
| C | ASN574 |
| C | ILE693 |
| C | HOH815 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 702 |
| Chain | Residue |
| C | HIS17 |
| C | GLY19 |
| C | ASP79 |
| C | ASP81 |
| C | HOH931 |
| site_id | DC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA C 703 |
| Chain | Residue |
| C | GLU51 |
| C | HOH801 |
| C | HOH807 |
| C | HOH1301 |
| D | ASN655 |
| D | HOH808 |
| D | HOH1176 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 704 |
| Chain | Residue |
| C | PHE232 |
| C | GLN235 |
| C | PHE236 |
| C | GLU375 |
| C | ASN586 |
| site_id | EC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT C 705 |
| Chain | Residue |
| C | HIS161 |
| C | SER175 |
| C | GLN179 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT C 706 |
| Chain | Residue |
| C | PHE630 |
| C | TYR636 |
| C | GLU685 |
| site_id | EC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT C 707 |
| Chain | Residue |
| C | LEU189 |
| C | GLY192 |
| C | SER193 |
| C | THR196 |
| C | LYS614 |
| C | ALA618 |
| C | HOH1014 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT C 708 |
| Chain | Residue |
| C | ASP205 |
| C | HIS208 |
| C | ALA223 |
| C | TRP226 |
| C | HIS227 |
| C | HOH1143 |
| site_id | EC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 709 |
| Chain | Residue |
| C | GLY503 |
| C | ILE506 |
| C | ALA507 |
| C | GLU553 |
| C | LYS556 |
| C | HOH1127 |
| site_id | EC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 710 |
| Chain | Residue |
| C | ALA22 |
| C | ASP41 |
| C | GLY43 |
| C | HOH1042 |
| C | HOH1282 |
| C | HOH1300 |
| D | ASP659 |
| D | GLU662 |
| site_id | EC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 711 |
| Chain | Residue |
| B | LYS517 |
| B | GLN523 |
| B | SER548 |
| B | PHE549 |
| C | LEU251 |
| C | SER253 |
| C | HOH884 |
| C | HOH972 |
| C | HOH995 |
| site_id | EC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 712 |
| Chain | Residue |
| C | ALA117 |
| C | TRP645 |
| C | GLU646 |
| C | ASP647 |
| site_id | EC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 713 |
| Chain | Residue |
| C | THR35 |
| C | ASP36 |
| C | PHE58 |
| site_id | FC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA C 714 |
| Chain | Residue |
| C | ASN655 |
| C | HOH818 |
| D | GLU51 |
| D | HOH803 |
| D | HOH804 |
| D | HOH805 |
| D | HOH827 |
| site_id | FC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ACD C 715 |
| Chain | Residue |
| C | TYR178 |
| C | ARG182 |
| C | GLN380 |
| C | HIS384 |
| C | LEU385 |
| C | HIS389 |
| C | GLY427 |
| C | LEU431 |
| C | ILE437 |
| C | SER441 |
| C | LEU627 |
| C | HOH1209 |
| site_id | FC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 716 |
| Chain | Residue |
| C | ASP659 |
| C | GLU662 |
| C | HOH1189 |
| C | HOH1289 |
| D | ALA22 |
| D | ASP41 |
| D | GLY43 |
| site_id | FC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 717 |
| Chain | Residue |
| C | ASN200 |
| C | TRP201 |
| C | ASP202 |
| C | ASP206 |
| site_id | FC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT C 718 |
| site_id | FC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 701 |
| Chain | Residue |
| D | PHE232 |
| D | GLN235 |
| D | GLU375 |
| D | ASN586 |
| site_id | FC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 D 702 |
| Chain | Residue |
| D | HIS384 |
| D | HIS389 |
| D | HIS570 |
| D | ASN574 |
| D | ILE693 |
| D | HOH819 |
| site_id | FC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 703 |
| Chain | Residue |
| D | HIS17 |
| D | GLY19 |
| D | ASP79 |
| D | ASP81 |
| D | HOH823 |
| site_id | FC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 704 |
| Chain | Residue |
| D | LEU189 |
| D | SER193 |
| D | THR196 |
| D | ALA618 |
| site_id | GC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT D 705 |
| Chain | Residue |
| D | ASP205 |
| D | ALA223 |
| D | TRP226 |
| site_id | GC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 706 |
| Chain | Residue |
| D | GLY503 |
| D | ALA507 |
| D | GLU553 |
| D | LYS556 |
| D | HOH900 |
| site_id | GC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 707 |
| Chain | Residue |
| D | ALA117 |
| D | LYS411 |
| D | TRP645 |
| D | GLU646 |
| D | ASP647 |
| site_id | GC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 708 |
| Chain | Residue |
| D | ASN200 |
| D | ASP202 |
| D | SER203 |
| D | ASP206 |
| site_id | GC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT D 709 |
| Chain | Residue |
| D | PHE630 |
| D | TYR636 |
| D | GLU685 |
| site_id | GC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 710 |
| Chain | Residue |
| D | GLN380 |
| D | SER441 |
| D | ALA589 |
| D | ALA620 |
| D | VAL624 |
| site_id | GC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT D 711 |
| Chain | Residue |
| D | GLY19 |
| D | THR20 |
| D | GLU46 |
Functional Information from PROSITE/UniProt
| site_id | PS00081 |
| Number of Residues | 11 |
| Details | LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. AHPIfKLLqPH |
| Chain | Residue | Details |
| A | ALA406-HIS416 | |
| site_id | PS00711 |
| Number of Residues | 15 |
| Details | LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HQlntHlLRTHLTtE |
| Chain | Residue | Details |
| A | HIS379-GLU393 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | HIS17 | |
| B | HIS17 | |
| B | GLY19 | |
| B | THR20 | |
| B | ASP21 | |
| B | GLU46 | |
| B | ALA47 | |
| B | SER49 | |
| B | TRP82 | |
| B | VAL84 | |
| C | HIS17 | |
| A | GLY19 | |
| C | GLY19 | |
| C | THR20 | |
| C | ASP21 | |
| C | GLU46 | |
| C | ALA47 | |
| C | SER49 | |
| C | TRP82 | |
| C | VAL84 | |
| D | HIS17 | |
| D | GLY19 | |
| A | THR20 | |
| D | THR20 | |
| D | ASP21 | |
| D | GLU46 | |
| D | ALA47 | |
| D | SER49 | |
| D | TRP82 | |
| D | VAL84 | |
| A | ASP21 | |
| A | GLU46 | |
| A | ALA47 | |
| A | SER49 | |
| A | TRP82 | |
| A | VAL84 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG387 | |
| C | ARG387 | |
| C | THR392 | |
| C | VAL573 | |
| C | GLN577 | |
| D | ARG387 | |
| D | THR392 | |
| D | VAL573 | |
| D | GLN577 | |
| A | THR392 | |
| A | VAL573 | |
| A | GLN577 | |
| B | ARG387 | |
| B | THR392 | |
| B | VAL573 | |
| B | GLN577 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | |
| Details | M-CSA 758 |
| site_id | MCSA2 |
| Number of Residues | |
| Details | M-CSA 758 |
| site_id | MCSA3 |
| Number of Residues | |
| Details | M-CSA 758 |
| site_id | MCSA4 |
| Number of Residues | |
| Details | M-CSA 758 |
