4QNK
The structure of wt A. thaliana IGPD2 in complex with Mn2+ and phosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | histidine biosynthetic process |
| A | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| B | 0000105 | biological_process | histidine biosynthetic process |
| B | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| C | 0000105 | biological_process | histidine biosynthetic process |
| C | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| D | 0000105 | biological_process | histidine biosynthetic process |
| D | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| E | 0000105 | biological_process | histidine biosynthetic process |
| E | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| F | 0000105 | biological_process | histidine biosynthetic process |
| F | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| G | 0000105 | biological_process | histidine biosynthetic process |
| G | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| H | 0000105 | biological_process | histidine biosynthetic process |
| H | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 301 |
| Chain | Residue |
| A | HIS47 |
| A | HIS169 |
| A | GLU173 |
| A | HOH417 |
| D | HIS74 |
| D | HOH478 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 302 |
| Chain | Residue |
| A | HOH424 |
| B | HIS170 |
| B | HOH410 |
| A | HIS73 |
| A | GLU77 |
| A | HIS145 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 303 |
| Chain | Residue |
| A | GLN51 |
| A | HIS55 |
| A | LYS177 |
| A | HOH551 |
| H | ARG99 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 304 |
| Chain | Residue |
| A | GLY96 |
| A | SER189 |
| A | ASP190 |
| A | ARG193 |
| A | HOH479 |
| A | HOH548 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 301 |
| Chain | Residue |
| A | HIS74 |
| B | HIS47 |
| B | HIS169 |
| B | GLU173 |
| B | HOH412 |
| B | HOH548 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 302 |
| Chain | Residue |
| B | HIS73 |
| B | GLU77 |
| B | HIS145 |
| B | HOH441 |
| C | HIS170 |
| C | HOH405 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 303 |
| Chain | Residue |
| B | GLN51 |
| B | HIS55 |
| B | ARG99 |
| B | LYS177 |
| B | HOH559 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 304 |
| Chain | Residue |
| B | ASN98 |
| B | GLU188 |
| B | SER189 |
| B | HOH543 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 305 |
| Chain | Residue |
| B | GLY96 |
| B | SER189 |
| B | ASP190 |
| B | ARG193 |
| B | HOH487 |
| B | HOH556 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 301 |
| Chain | Residue |
| B | HIS74 |
| C | HIS47 |
| C | HIS169 |
| C | GLU173 |
| C | HOH536 |
| C | HOH539 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 302 |
| Chain | Residue |
| C | HIS73 |
| C | GLU77 |
| C | HIS145 |
| C | HOH547 |
| D | HIS170 |
| D | HOH514 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 C 303 |
| Chain | Residue |
| A | ARG99 |
| C | GLN51 |
| C | HIS55 |
| C | LYS177 |
| C | HOH512 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 304 |
| Chain | Residue |
| C | LEU88 |
| C | ARG94 |
| C | LEU118 |
| C | SER119 |
| C | GLY120 |
| C | SER154 |
| C | GLY155 |
| C | HOH563 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 305 |
| Chain | Residue |
| C | GLY96 |
| C | SER189 |
| C | ASP190 |
| C | ARG193 |
| C | HOH462 |
| C | HOH498 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 301 |
| Chain | Residue |
| A | HIS170 |
| A | HOH408 |
| D | HIS73 |
| D | GLU77 |
| D | HIS145 |
| D | HOH417 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 302 |
| Chain | Residue |
| C | HIS74 |
| D | HIS47 |
| D | HIS169 |
| D | GLU173 |
| D | HOH428 |
| D | HOH471 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 D 303 |
| Chain | Residue |
| D | GLN51 |
| D | HIS55 |
| D | LYS177 |
| G | ARG99 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 304 |
| Chain | Residue |
| D | ASP190 |
| D | ARG193 |
| D | HOH520 |
| D | HOH532 |
| D | GLY96 |
| D | SER189 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN E 301 |
| Chain | Residue |
| E | HIS47 |
| E | HIS169 |
| E | GLU173 |
| E | HOH404 |
| H | HIS74 |
| H | HOH535 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN E 302 |
| Chain | Residue |
| E | HIS73 |
| E | GLU77 |
| E | HIS145 |
| E | HOH456 |
| F | HIS170 |
| F | HOH408 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 E 303 |
| Chain | Residue |
| D | ARG99 |
| E | GLN51 |
| E | HIS55 |
| E | LYS177 |
| E | HOH560 |
| E | HOH561 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO E 304 |
| Chain | Residue |
| E | LEU88 |
| E | LEU118 |
| E | SER119 |
| E | GLY120 |
| E | SER154 |
| E | GLY155 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA E 305 |
| Chain | Residue |
| E | GLY96 |
| E | SER189 |
| E | ASP190 |
| E | ARG193 |
| E | HOH405 |
| E | HOH500 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN F 301 |
| Chain | Residue |
| E | HIS74 |
| F | HIS47 |
| F | HIS169 |
| F | GLU173 |
| F | HOH429 |
| F | HOH469 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN F 302 |
| Chain | Residue |
| F | HIS73 |
| F | GLU77 |
| F | HIS145 |
| F | HOH428 |
| G | HIS170 |
| G | HOH405 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 F 303 |
| Chain | Residue |
| F | GLN51 |
| F | HIS55 |
| F | ARG99 |
| F | LYS177 |
| F | HOH509 |
| F | HOH548 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA F 304 |
| Chain | Residue |
| F | GLY96 |
| F | SER189 |
| F | ASP190 |
| F | ARG193 |
| F | HOH540 |
| F | HOH546 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN G 301 |
| Chain | Residue |
| F | HIS74 |
| G | HIS47 |
| G | HIS169 |
| G | GLU173 |
| G | HOH404 |
| G | HOH539 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN G 302 |
| Chain | Residue |
| G | HIS73 |
| G | GLU77 |
| G | HIS145 |
| G | HOH424 |
| H | HIS170 |
| H | HOH418 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 G 303 |
| Chain | Residue |
| E | ARG99 |
| G | GLN51 |
| G | HIS55 |
| G | LYS177 |
| G | HOH506 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO G 304 |
| Chain | Residue |
| G | LEU88 |
| G | LEU118 |
| G | SER119 |
| G | GLY120 |
| G | SER154 |
| G | GLY155 |
| site_id | DC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA G 305 |
| Chain | Residue |
| G | GLY96 |
| G | SER189 |
| G | ASP190 |
| G | ARG193 |
| G | HOH525 |
| G | HOH538 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN H 301 |
| Chain | Residue |
| E | HIS170 |
| E | HOH422 |
| H | HIS73 |
| H | GLU77 |
| H | HIS145 |
| H | HOH429 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN H 302 |
| Chain | Residue |
| G | HIS74 |
| H | HIS47 |
| H | HIS169 |
| H | GLU173 |
| H | HOH420 |
| H | HOH491 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 H 303 |
| Chain | Residue |
| C | ARG99 |
| H | GLN51 |
| H | HIS55 |
| H | LYS177 |
| H | HOH507 |
| site_id | DC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA H 304 |
| Chain | Residue |
| H | GLY96 |
| H | SER189 |
| H | ASP190 |
| H | ARG193 |
| H | HOH504 |
| H | HOH531 |
Functional Information from PROSITE/UniProt
| site_id | PS00954 |
| Number of Residues | 14 |
| Details | IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IDdHHtnEdvALAI |
| Chain | Residue | Details |
| A | ILE70-ILE83 |
| site_id | PS00955 |
| Number of Residues | 13 |
| Details | IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GkNsHHiiEAtFK |
| Chain | Residue | Details |
| A | GLY165-LYS177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27717128, ECO:0007744|PDB:5EKW, ECO:0007744|PDB:5EL9, ECO:0007744|PDB:5ELW |
| Chain | Residue | Details |
| A | GLU21 | |
| B | GLU21 | |
| C | GLU21 | |
| D | GLU21 | |
| E | GLU21 | |
| F | GLU21 | |
| G | GLU21 | |
| H | GLU21 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26095028, ECO:0000269|PubMed:27717128, ECO:0007744|PDB:4MU0, ECO:0007744|PDB:4MU1, ECO:0007744|PDB:4MU4, ECO:0007744|PDB:4QNJ, ECO:0007744|PDB:4QNK, ECO:0007744|PDB:5EKW, ECO:0007744|PDB:5EL9, ECO:0007744|PDB:5ELW |
| Chain | Residue | Details |
| A | HIS47 | |
| C | HIS74 | |
| C | HIS169 | |
| C | GLU173 | |
| D | HIS47 | |
| D | HIS74 | |
| D | HIS169 | |
| D | GLU173 | |
| E | HIS47 | |
| E | HIS74 | |
| E | HIS169 | |
| A | HIS74 | |
| E | GLU173 | |
| F | HIS47 | |
| F | HIS74 | |
| F | HIS169 | |
| F | GLU173 | |
| G | HIS47 | |
| G | HIS74 | |
| G | HIS169 | |
| G | GLU173 | |
| H | HIS47 | |
| A | HIS169 | |
| H | HIS74 | |
| H | HIS169 | |
| H | GLU173 | |
| A | GLU173 | |
| B | HIS47 | |
| B | HIS74 | |
| B | HIS169 | |
| B | GLU173 | |
| C | HIS47 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26095028, ECO:0000269|PubMed:27717128, ECO:0007744|PDB:4MU0, ECO:0007744|PDB:4MU3, ECO:0007744|PDB:4MU4, ECO:0007744|PDB:4QNJ, ECO:0007744|PDB:4QNK, ECO:0007744|PDB:5ELW |
| Chain | Residue | Details |
| A | HIS73 | |
| C | GLU77 | |
| C | HIS145 | |
| C | HIS170 | |
| D | HIS73 | |
| D | GLU77 | |
| D | HIS145 | |
| D | HIS170 | |
| E | HIS73 | |
| E | GLU77 | |
| E | HIS145 | |
| A | GLU77 | |
| E | HIS170 | |
| F | HIS73 | |
| F | GLU77 | |
| F | HIS145 | |
| F | HIS170 | |
| G | HIS73 | |
| G | GLU77 | |
| G | HIS145 | |
| G | HIS170 | |
| H | HIS73 | |
| A | HIS145 | |
| H | GLU77 | |
| H | HIS145 | |
| H | HIS170 | |
| A | HIS170 | |
| B | HIS73 | |
| B | GLU77 | |
| B | HIS145 | |
| B | HIS170 | |
| C | HIS73 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26095028, ECO:0000269|PubMed:27717128, ECO:0007744|PDB:4MU3, ECO:0007744|PDB:4MU4, ECO:0007744|PDB:4QNK, ECO:0007744|PDB:5EKW, ECO:0007744|PDB:5EL9, ECO:0007744|PDB:5ELW |
| Chain | Residue | Details |
| A | ARG99 | |
| B | ARG99 | |
| C | ARG99 | |
| D | ARG99 | |
| E | ARG99 | |
| F | ARG99 | |
| G | ARG99 | |
| H | ARG99 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26095028, ECO:0000269|PubMed:27717128, ECO:0007744|PDB:4MU4, ECO:0007744|PDB:5EKW, ECO:0007744|PDB:5EL9, ECO:0007744|PDB:5ELW |
| Chain | Residue | Details |
| A | ARG121 | |
| E | SER199 | |
| F | ARG121 | |
| F | SER199 | |
| G | ARG121 | |
| G | SER199 | |
| H | ARG121 | |
| H | SER199 | |
| A | SER199 | |
| B | ARG121 | |
| B | SER199 | |
| C | ARG121 | |
| C | SER199 | |
| D | ARG121 | |
| D | SER199 | |
| E | ARG121 |
