Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4QNK

The structure of wt A. thaliana IGPD2 in complex with Mn2+ and phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
B	0000105	biological_process	L-histidine biosynthetic process
B	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
C	0000105	biological_process	L-histidine biosynthetic process
C	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
D	0000105	biological_process	L-histidine biosynthetic process
D	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
E	0000105	biological_process	L-histidine biosynthetic process
E	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
F	0000105	biological_process	L-histidine biosynthetic process
F	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
G	0000105	biological_process	L-histidine biosynthetic process
G	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
H	0000105	biological_process	L-histidine biosynthetic process
H	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 301

Chain	Residue
A	HIS47
A	HIS169
A	GLU173
A	HOH417
D	HIS74
D	HOH478

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 302

Chain	Residue
A	HOH424
B	HIS170
B	HOH410
A	HIS73
A	GLU77
A	HIS145

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 303

Chain	Residue
A	GLN51
A	HIS55
A	LYS177
A	HOH551
H	ARG99

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 304

Chain	Residue
A	GLY96
A	SER189
A	ASP190
A	ARG193
A	HOH479
A	HOH548

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 301

Chain	Residue
A	HIS74
B	HIS47
B	HIS169
B	GLU173
B	HOH412
B	HOH548

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 302

Chain	Residue
B	HIS73
B	GLU77
B	HIS145
B	HOH441
C	HIS170
C	HOH405

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 303

Chain	Residue
B	GLN51
B	HIS55
B	ARG99
B	LYS177
B	HOH559

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 304

Chain	Residue
B	ASN98
B	GLU188
B	SER189
B	HOH543

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 305

Chain	Residue
B	GLY96
B	SER189
B	ASP190
B	ARG193
B	HOH487
B	HOH556

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 301

Chain	Residue
B	HIS74
C	HIS47
C	HIS169
C	GLU173
C	HOH536
C	HOH539

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 302

Chain	Residue
C	HIS73
C	GLU77
C	HIS145
C	HOH547
D	HIS170
D	HOH514

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 C 303

Chain	Residue
A	ARG99
C	GLN51
C	HIS55
C	LYS177
C	HOH512

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO C 304

Chain	Residue
C	LEU88
C	ARG94
C	LEU118
C	SER119
C	GLY120
C	SER154
C	GLY155
C	HOH563

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 305

Chain	Residue
C	GLY96
C	SER189
C	ASP190
C	ARG193
C	HOH462
C	HOH498

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 301

Chain	Residue
A	HIS170
A	HOH408
D	HIS73
D	GLU77
D	HIS145
D	HOH417

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 302

Chain	Residue
C	HIS74
D	HIS47
D	HIS169
D	GLU173
D	HOH428
D	HOH471

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 D 303

Chain	Residue
D	GLN51
D	HIS55
D	LYS177
G	ARG99

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 304

Chain	Residue
D	ASP190
D	ARG193
D	HOH520
D	HOH532
D	GLY96
D	SER189

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 301

Chain	Residue
E	HIS47
E	HIS169
E	GLU173
E	HOH404
H	HIS74
H	HOH535

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 302

Chain	Residue
E	HIS73
E	GLU77
E	HIS145
E	HOH456
F	HIS170
F	HOH408

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 E 303

Chain	Residue
D	ARG99
E	GLN51
E	HIS55
E	LYS177
E	HOH560
E	HOH561

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 304

Chain	Residue
E	LEU88
E	LEU118
E	SER119
E	GLY120
E	SER154
E	GLY155

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 305

Chain	Residue
E	GLY96
E	SER189
E	ASP190
E	ARG193
E	HOH405
E	HOH500

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 301

Chain	Residue
E	HIS74
F	HIS47
F	HIS169
F	GLU173
F	HOH429
F	HOH469

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 302

Chain	Residue
F	HIS73
F	GLU77
F	HIS145
F	HOH428
G	HIS170
G	HOH405

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 F 303

Chain	Residue
F	GLN51
F	HIS55
F	ARG99
F	LYS177
F	HOH509
F	HOH548

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA F 304

Chain	Residue
F	GLY96
F	SER189
F	ASP190
F	ARG193
F	HOH540
F	HOH546

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 301

Chain	Residue
F	HIS74
G	HIS47
G	HIS169
G	GLU173
G	HOH404
G	HOH539

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 302

Chain	Residue
G	HIS73
G	GLU77
G	HIS145
G	HOH424
H	HIS170
H	HOH418

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 G 303

Chain	Residue
E	ARG99
G	GLN51
G	HIS55
G	LYS177
G	HOH506

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO G 304

Chain	Residue
G	LEU88
G	LEU118
G	SER119
G	GLY120
G	SER154
G	GLY155

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA G 305

Chain	Residue
G	GLY96
G	SER189
G	ASP190
G	ARG193
G	HOH525
G	HOH538

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN H 301

Chain	Residue
E	HIS170
E	HOH422
H	HIS73
H	GLU77
H	HIS145
H	HOH429

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN H 302

Chain	Residue
G	HIS74
H	HIS47
H	HIS169
H	GLU173
H	HOH420
H	HOH491

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 H 303

Chain	Residue
C	ARG99
H	GLN51
H	HIS55
H	LYS177
H	HOH507

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA H 304

Chain	Residue
H	GLY96
H	SER189
H	ASP190
H	ARG193
H	HOH504
H	HOH531

Functional Information from PROSITE/UniProt

site_id	PS00954
Number of Residues	14
Details	IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IDdHHtnEdvALAI

Chain	Residue	Details
A	ILE70-ILE83

site_id	PS00955
Number of Residues	13
Details	IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GkNsHHiiEAtFK

Chain	Residue	Details
A	GLY165-LYS177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)