4MU4

The form B structure of an E21Q catalytic mutant of A. thaliana IGPD2 in complex with Mn2+ and its substrate, 2R3S-IGP, to 1.41 A resolution

Summary for 4MU4

Entry DOI	10.2210/pdb4mu4/pdb
Related	4MU0 4MU1 4MU2 4MU3
Descriptor	Imidazoleglycerol-phosphate dehydratase 2, chloroplastic, MANGANESE (II) ION, (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate, ... (5 entities in total)
Functional Keywords	hydro-lyase, histidine biosynthesis, manganese binding, chloroplastic, lyase
Biological source	Arabidopsis thaliana (mouse-ear cress)
Cellular location	Plastid, chloroplast : O23346
Total number of polymer chains	1
Total formula weight	22924.36
Authors	Bisson, C.,Britton, K.L.,Sedelnikova, S.E.,Baker, P.J.,Rice, D.W. (deposition date: 2013-09-20, release date: 2014-09-24, Last modification date: 2023-09-20)
Primary citation	Bisson, C.,Britton, K.L.,Sedelnikova, S.E.,Rodgers, H.F.,Eadsforth, T.C.,Viner, R.C.,Hawkes, T.R.,Baker, P.J.,Rice, D.W. Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination. Structure, 23:1236-1245, 2015 Cited by PubMed: 26095028 DOI: 10.1016/j.str.2015.05.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.41 Å)

Structure validation