4QKD
Crystal structure of human ALKBH7 in complex with alpha-ketoglutarate and Mn(II)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0010883 | biological_process | regulation of lipid storage |
| A | 0012501 | biological_process | programmed cell death |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0035513 | biological_process | oxidative RNA demethylation |
| A | 0035515 | molecular_function | oxidative RNA demethylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 1902445 | biological_process | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death |
| A | 1990984 | molecular_function | tRNA demethylase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006974 | biological_process | DNA damage response |
| B | 0010883 | biological_process | regulation of lipid storage |
| B | 0012501 | biological_process | programmed cell death |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0035513 | biological_process | oxidative RNA demethylation |
| B | 0035515 | molecular_function | oxidative RNA demethylase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051213 | molecular_function | dioxygenase activity |
| B | 1902445 | biological_process | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death |
| B | 1990984 | molecular_function | tRNA demethylase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006974 | biological_process | DNA damage response |
| C | 0010883 | biological_process | regulation of lipid storage |
| C | 0012501 | biological_process | programmed cell death |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0035513 | biological_process | oxidative RNA demethylation |
| C | 0035515 | molecular_function | oxidative RNA demethylase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051213 | molecular_function | dioxygenase activity |
| C | 1902445 | biological_process | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death |
| C | 1990984 | molecular_function | tRNA demethylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 301 |
| Chain | Residue |
| A | HIS121 |
| A | ASP123 |
| A | HIS177 |
| A | AKG302 |
| A | HOH437 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AKG A 302 |
| Chain | Residue |
| A | ASP123 |
| A | TYR165 |
| A | HIS177 |
| A | ARG197 |
| A | SER199 |
| A | ARG203 |
| A | MN301 |
| A | HOH404 |
| A | HOH434 |
| A | HOH437 |
| A | HIS108 |
| A | LED110 |
| A | ILE118 |
| A | HIS121 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 303 |
| Chain | Residue |
| A | GLU62 |
| A | GLU75 |
| A | HOH422 |
| A | HOH442 |
| A | HOH446 |
| C | HIS65 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 301 |
| Chain | Residue |
| B | HIS121 |
| B | ASP123 |
| B | HIS177 |
| B | AKG302 |
| B | HOH427 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE AKG B 302 |
| Chain | Residue |
| B | HIS108 |
| B | LED110 |
| B | ILE118 |
| B | HIS121 |
| B | ASP123 |
| B | TYR165 |
| B | HIS177 |
| B | ARG197 |
| B | SER199 |
| B | ILE201 |
| B | ARG203 |
| B | MN301 |
| B | HOH419 |
| B | HOH427 |
| B | HOH446 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 303 |
| Chain | Residue |
| A | HIS65 |
| B | GLU62 |
| B | GLU75 |
| B | HOH409 |
| B | HOH444 |
| B | HOH449 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 304 |
| Chain | Residue |
| A | GLU189 |
| B | GLU189 |
| B | HOH502 |
| B | HOH528 |
| B | HOH554 |
| C | GLU189 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN C 301 |
| Chain | Residue |
| C | HIS121 |
| C | ASP123 |
| C | HIS177 |
| C | AKG302 |
| C | HOH421 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE AKG C 302 |
| Chain | Residue |
| B | HOH662 |
| C | HIS108 |
| C | LED110 |
| C | ILE118 |
| C | HIS121 |
| C | ASP123 |
| C | TYR165 |
| C | HIS177 |
| C | ARG197 |
| C | SER199 |
| C | ILE201 |
| C | ARG203 |
| C | MN301 |
| C | HOH401 |
| C | HOH421 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 303 |
| Chain | Residue |
| B | HIS65 |
| C | GLU62 |
| C | GLU75 |
| C | HOH476 |
| C | HOH477 |
| C | HOH479 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25122757","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25122757","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
