4QK4

Crystal structure of human nuclear receptor sf-1 (nr5a1) bound to pip2 at 2.8 a resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PIK A 501

Chain	Residue
A	PHE262
A	LEU347
A	LEU429
A	TYR436
A	HIS439
A	LYS440
A	HOH651
A	HOH652
A	LEU265
A	CYS266
A	SER303
A	LEU306
A	VAL307
A	ALA340
A	GLY341
A	LEU344

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 502

Chain	Residue
A	SER275
A	ASP309
A	ARG313

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 503

Chain	Residue
A	GLN314
A	GLY318
A	GLN352

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 504

Chain	Residue
A	LEU456
A	LEU456

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 505

Chain	Residue
A	GLN357
A	CYS422

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 506

Chain	Residue
A	VAL424
A	GLU425
A	ALA428
A	HOH647

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	237
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	231
Details	Region: {"description":"Important for dimerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15897460","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"LXXLL motif","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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