4QEO

crystal structure of KRYPTONITE in complex with mCHH DNA, H3(1-15) peptide and SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAH A 801

Chain	Residue
A	LYS456
A	ALA611
A	CYS612
A	TYR613
A	CYS614
P	LYS9
A	GLY457
A	TRP458
A	GLU492
A	TYR493
A	ARG548
A	ASN551
A	HIS552
A	TYR593

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 802

Chain	Residue
A	CYS383
A	CYS397
A	CYS425
A	CYS429

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 803

Chain	Residue
A	CYS389
A	CYS425
A	CYS431
A	CYS435

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 804

Chain	Residue
A	CYS383
A	CYS385
A	CYS389
A	CYS395

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 805

Chain	Residue
A	CYS554
A	CYS612
A	CYS614
A	CYS619

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR CHAIN P OF HISTONE H3

Chain	Residue
A	SER418
A	ARG419
A	ASP420
A	TYR475
A	GLU492
A	ILE494
A	PHE495
A	GLU496
A	TYR591
A	TYR593
A	GLY594
A	TYR595
A	SAH801

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DLNDGRLIEsrDV

Chain	Residue	Details
A	ASP409-VAL421

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Citrulline; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	CYS395
A	CYS397
A	CYS425
A	CYS429
A	CYS431
A	CYS435
A	LYS456
A	ASN551
A	CYS554
A	CYS612
A	CYS614
A	CYS619
A	CYS385
A	CYS389
P	ARG2

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by HASPIN => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	ARG548
P	THR3

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12138181

Chain	Residue	Details
P	LYS4

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
P	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
P	THR6
P	THR11

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250

Chain	Residue	Details
P	ARG8

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000305|PubMed:12138181

Chain	Residue	Details
P	LYS9

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
P	SER10

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
P	LYS14

---