Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4QEB

Dcps in complex with covalent inhibitor targeting Tyrosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
A	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
A	0000340	molecular_function	RNA 7-methylguanosine cap binding
A	0000932	cellular_component	P-body
A	0004532	molecular_function	RNA exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0110156	biological_process	mRNA methylguanosine-cap decapping
A	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
B	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
B	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
B	0000340	molecular_function	RNA 7-methylguanosine cap binding
B	0000932	cellular_component	P-body
B	0004532	molecular_function	RNA exonuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
B	0045292	biological_process	mRNA cis splicing, via spliceosome
B	0110156	biological_process	mRNA methylguanosine-cap decapping
B	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
C	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
C	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
C	0000340	molecular_function	RNA 7-methylguanosine cap binding
C	0000932	cellular_component	P-body
C	0004532	molecular_function	RNA exonuclease activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
C	0045292	biological_process	mRNA cis splicing, via spliceosome
C	0110156	biological_process	mRNA methylguanosine-cap decapping
C	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
D	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
D	0000340	molecular_function	RNA 7-methylguanosine cap binding
D	0000932	cellular_component	P-body
D	0004532	molecular_function	RNA exonuclease activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0016787	molecular_function	hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
D	0045292	biological_process	mRNA cis splicing, via spliceosome
D	0110156	biological_process	mRNA methylguanosine-cap decapping
D	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 401

Chain	Residue
A	HIS268
A	PRO271
A	SER272
A	TYR273
A	HIS277
A	HIS279
A	ARG294

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 402

Chain	Residue
A	HIS311
A	TYR312
B	GLU300
A	HIS296
A	ASN304

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 31G B 401

Chain	Residue
A	HIS139
A	LYS142
A	TYR143
A	TRP175
A	GLU185
A	PRO204
A	ASP205
A	LEU206
A	ILE219
A	SER272
A	TYR273
B	TYR113

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 402

Chain	Residue
B	HIS268
B	SER272
B	TYR273
B	HIS277
B	HIS279
B	ARG294

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 401

Chain	Residue
C	HIS268
C	PRO271
C	SER272
C	TYR273
C	HIS277
C	HIS279
C	ARG294

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. RvylhYlPsYyHLHVHFTA

Chain	Residue	Details
A	ARG264-ALA282

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
A	HIS277
B	HIS277
C	HIS277
D	HIS277

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:15068804, ECO:0000269\|PubMed:15769464

Chain	Residue	Details
A	TRP175
C	GLU185
C	ASP205
C	LYS207
D	TRP175
D	GLU185
D	ASP205
D	LYS207
A	GLU185
A	ASP205
A	LYS207
B	TRP175
B	GLU185
B	ASP205
B	LYS207
C	TRP175

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	HIS268
B	HIS268
C	HIS268
D	HIS268

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.6, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER24
B	SER24
C	SER24
D	SER24

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q9DAR7

Chain	Residue	Details
A	SER101
B	SER101
C	SER101
D	SER101

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS138
A	LYS142
B	LYS138
B	LYS142
C	LYS138
C	LYS142
D	LYS138
D	LYS142

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)