Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4Q66

Structure of Exomer bound to Arf1.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0046983	molecular_function	protein dimerization activity
B	0005515	molecular_function	protein binding
B	0005794	cellular_component	Golgi apparatus
B	0006031	biological_process	chitin biosynthetic process
B	0006893	biological_process	Golgi to plasma membrane transport
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0031267	molecular_function	small GTPase binding
B	0034044	cellular_component	exomer complex
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006886	biological_process	intracellular protein transport
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006893	biological_process	Golgi to plasma membrane transport
C	0010636	biological_process	positive regulation of mitochondrial fusion
C	0015031	biological_process	protein transport
C	0016192	biological_process	vesicle-mediated transport
C	0016236	biological_process	macroautophagy
C	0016787	molecular_function	hydrolase activity
C	0019217	biological_process	regulation of fatty acid metabolic process
C	0044232	cellular_component	organelle membrane contact site
C	0048193	biological_process	Golgi vesicle transport
C	0090141	biological_process	positive regulation of mitochondrial fission
C	1903292	biological_process	protein localization to Golgi membrane
C	1903358	biological_process	regulation of Golgi organization
D	0046983	molecular_function	protein dimerization activity
E	0005515	molecular_function	protein binding
E	0005794	cellular_component	Golgi apparatus
E	0006031	biological_process	chitin biosynthetic process
E	0006893	biological_process	Golgi to plasma membrane transport
E	0015031	biological_process	protein transport
E	0016020	cellular_component	membrane
E	0031267	molecular_function	small GTPase binding
E	0034044	cellular_component	exomer complex
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006886	biological_process	intracellular protein transport
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006893	biological_process	Golgi to plasma membrane transport
F	0010636	biological_process	positive regulation of mitochondrial fusion
F	0015031	biological_process	protein transport
F	0016192	biological_process	vesicle-mediated transport
F	0016236	biological_process	macroautophagy
F	0016787	molecular_function	hydrolase activity
F	0019217	biological_process	regulation of fatty acid metabolic process
F	0044232	cellular_component	organelle membrane contact site
F	0048193	biological_process	Golgi vesicle transport
F	0090141	biological_process	positive regulation of mitochondrial fission
F	1903292	biological_process	protein localization to Golgi membrane
F	1903358	biological_process	regulation of Golgi organization
G	0046983	molecular_function	protein dimerization activity
H	0005515	molecular_function	protein binding
H	0005794	cellular_component	Golgi apparatus
H	0006031	biological_process	chitin biosynthetic process
H	0006893	biological_process	Golgi to plasma membrane transport
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0031267	molecular_function	small GTPase binding
H	0034044	cellular_component	exomer complex
I	0003924	molecular_function	GTPase activity
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006886	biological_process	intracellular protein transport
I	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
I	0006893	biological_process	Golgi to plasma membrane transport
I	0010636	biological_process	positive regulation of mitochondrial fusion
I	0015031	biological_process	protein transport
I	0016192	biological_process	vesicle-mediated transport
I	0016236	biological_process	macroautophagy
I	0016787	molecular_function	hydrolase activity
I	0019217	biological_process	regulation of fatty acid metabolic process
I	0044232	cellular_component	organelle membrane contact site
I	0048193	biological_process	Golgi vesicle transport
I	0090141	biological_process	positive regulation of mitochondrial fission
I	1903292	biological_process	protein localization to Golgi membrane
I	1903358	biological_process	regulation of Golgi organization
J	0046983	molecular_function	protein dimerization activity
K	0005515	molecular_function	protein binding
K	0005794	cellular_component	Golgi apparatus
K	0006031	biological_process	chitin biosynthetic process
K	0006893	biological_process	Golgi to plasma membrane transport
K	0015031	biological_process	protein transport
K	0016020	cellular_component	membrane
K	0031267	molecular_function	small GTPase binding
K	0034044	cellular_component	exomer complex
L	0003924	molecular_function	GTPase activity
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006886	biological_process	intracellular protein transport
L	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
L	0006893	biological_process	Golgi to plasma membrane transport
L	0010636	biological_process	positive regulation of mitochondrial fusion
L	0015031	biological_process	protein transport
L	0016192	biological_process	vesicle-mediated transport
L	0016236	biological_process	macroautophagy
L	0016787	molecular_function	hydrolase activity
L	0019217	biological_process	regulation of fatty acid metabolic process
L	0044232	cellular_component	organelle membrane contact site
L	0048193	biological_process	Golgi vesicle transport
L	0090141	biological_process	positive regulation of mitochondrial fission
L	1903292	biological_process	protein localization to Golgi membrane
L	1903358	biological_process	regulation of Golgi organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP F 201

Chain	Residue
F	ASP26
F	GLY70
F	ASN126
F	LYS127
F	ASP129
F	LEU130
F	CYS159
F	ALA160
F	THR161
F	MG202
F	GLY27
F	ALA28
F	GLY29
F	LYS30
F	THR31
F	THR32
F	PRO47
F	THR48

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 202

Chain	Residue
F	THR31
F	THR48
F	ASP67
F	GNP201

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP L 201

Chain	Residue
L	LEU25
L	ASP26
L	GLY27
L	ALA28
L	GLY29
L	LYS30
L	THR31
L	THR32
L	THR45
L	ILE46
L	PRO47
L	THR48
L	GLY70
L	ASN126
L	LYS127
L	CYS159
L	ALA160
L	MG202

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG L 202

Chain	Residue
L	THR31
L	THR48
L	GNP201

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GNP C 201

Chain	Residue
C	LEU25
C	ASP26
C	GLY27
C	ALA28
C	GLY29
C	LYS30
C	THR31
C	THR32
C	THR45
C	ILE46
C	PRO47
C	THR48
C	GLY70
C	ASN126
C	LYS127
C	ASP129
C	CYS159
C	ALA160
C	THR161
C	MG202

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 202

Chain	Residue
C	THR31
C	THR48
C	GNP201

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP I 201

Chain	Residue
I	LEU25
I	ASP26
I	GLY27
I	ALA28
I	LYS30
I	THR31
I	THR32
I	THR45
I	PRO47
I	THR48
I	GLY70
I	ASN126
I	LYS127
I	ASP129
I	CYS159
I	ALA160
I	THR161
I	MG202

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG I 202

Chain	Residue
I	THR31
I	THR48
I	GNP201

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:20601958

Chain	Residue	Details
F	LEU25
L	ALA160
C	LEU25
C	THR48
C	GLY70
C	ASN126
C	ALA160
I	LEU25
I	THR48
I	GLY70
I	ASN126
F	THR48
I	ALA160
F	GLY70
F	ASN126
F	ALA160
L	LEU25
L	THR48
L	GLY70
L	ASN126

site_id	SWS_FT_FI2
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744\|PubMed:22106047

Chain	Residue	Details
F	LYS127
L	LYS127
C	LYS127
I	LYS127

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)