4PLE

Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to an E. Coli Phospholipid and a Fragment of TIF-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
E	0003677	molecular_function	DNA binding
E	0004879	molecular_function	nuclear receptor activity
G	0003677	molecular_function	DNA binding
G	0004879	molecular_function	nuclear receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue EPH A 601

Chain	Residue
A	THR341
A	GLY421
A	LEU424
A	LEU427
A	MET428
A	ALA431
A	ALA513
A	TYR516
A	LYS520
A	HOH714
A	PHE342
A	MET345
A	LEU386
A	HIS390
A	ILE415
A	ILE416
A	GLN419
A	ALA420

---

site_id	AC2
Number of Residues	10
Details	binding site for residue CPS A 602

Chain	Residue
A	MET323
A	LEU326
A	GLN330
A	THR341
A	LEU344
A	LEU405
A	THR407
A	GLN409
A	HOH734
A	HOH757

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CPS A 603

Chain	Residue
A	TYR518
A	LEU536
G	LEU482

---

site_id	AC4
Number of Residues	7
Details	binding site for residue CPS A 604

Chain	Residue
A	GLU515
A	TYR519
E	HIS336
G	GLU471
G	GLN474
G	GLU475
G	ASN478

---

site_id	AC5
Number of Residues	16
Details	binding site for residue EPH C 601

Chain	Residue
C	THR341
C	PHE342
C	MET345
C	LEU386
C	HIS390
C	ILE416
C	GLN419
C	ALA420
C	GLY421
C	LEU424
C	LEU427
C	MET428
C	ILE509
C	TYR516
C	LYS520
C	HOH711

---

site_id	AC6
Number of Residues	10
Details	binding site for residue CPS C 602

Chain	Residue
C	MET323
C	LEU326
C	GLN330
C	THR341
C	LEU344
C	THR407
C	GLN409
C	HOH706
C	HOH708
C	HOH741

---

site_id	AC7
Number of Residues	1
Details	binding site for residue CPS C 603

Chain	Residue
C	LEU482

---

site_id	AC8
Number of Residues	16
Details	binding site for residue EPH E 601

Chain	Residue
E	THR341
E	PHE342
E	MET345
E	LEU386
E	ILE387
E	HIS390
E	ILE415
E	ILE416
E	GLN419
E	GLY421
E	LEU424
E	MET428
E	ALA513
E	GLU514
E	TYR516
E	LYS520

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CPS E 602

Chain	Residue
E	GLU475
E	ASN478
E	LEU482
E	CPS604
G	HIS336

---

site_id	AD1
Number of Residues	9
Details	binding site for residue CPS E 603

Chain	Residue
A	GLU471
A	GLU475
A	ASN478
E	THR423
E	GLU515
E	TYR519
E	CPS606
E	HOH723
E	HOH736

---

site_id	AD2
Number of Residues	2
Details	binding site for residue CPS E 604

Chain	Residue
E	LEU482
E	CPS602

---

site_id	AD3
Number of Residues	8
Details	binding site for residue CPS E 605

Chain	Residue
E	GLN330
E	LEU344
E	THR407
E	GLN409
E	HOH712
E	HOH733
E	MET323
E	LEU326

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CPS E 606

Chain	Residue
E	TYR518
E	LEU536
E	CPS603
E	HOH771

---

site_id	AD5
Number of Residues	15
Details	binding site for residue EPH G 601

Chain	Residue
G	THR341
G	PHE342
G	MET345
G	LEU386
G	ILE387
G	HIS390
G	ILE415
G	ILE416
G	GLN419
G	GLY421
G	LEU424
G	MET428
G	TYR516
G	LYS520
G	HOH703

---

site_id	AD6
Number of Residues	4
Details	binding site for residue CPS G 602

Chain	Residue
G	THR423
G	GLU515
G	TYR519
G	HOH727

---

site_id	AD7
Number of Residues	8
Details	binding site for residue CPS G 603

Chain	Residue
G	MET323
G	LEU326
G	GLN330
G	LEU344
G	LEU405
G	THR407
G	GLN409
G	HOH708

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15897460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22187462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22504882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26416531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26553876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RWV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"LXXLL motif 3"}

Chain

Residue

Details

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