4PEH

Dbr1 in complex with synthetic linear RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005506	molecular_function	iron ion binding
A	0005634	cellular_component	nucleus
A	0006397	biological_process	mRNA processing
A	0008270	molecular_function	zinc ion binding
A	0008419	molecular_function	RNA lariat debranching enzyme activity
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
B	0000375	biological_process	RNA splicing, via transesterification reactions
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0005506	molecular_function	iron ion binding
B	0005634	cellular_component	nucleus
B	0006397	biological_process	mRNA processing
B	0008270	molecular_function	zinc ion binding
B	0008419	molecular_function	RNA lariat debranching enzyme activity
B	0016787	molecular_function	hydrolase activity
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
C	0000375	biological_process	RNA splicing, via transesterification reactions
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003723	molecular_function	RNA binding
C	0005506	molecular_function	iron ion binding
C	0005634	cellular_component	nucleus
C	0006397	biological_process	mRNA processing
C	0008270	molecular_function	zinc ion binding
C	0008419	molecular_function	RNA lariat debranching enzyme activity
C	0016787	molecular_function	hydrolase activity
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
D	0000375	biological_process	RNA splicing, via transesterification reactions
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003723	molecular_function	RNA binding
D	0005506	molecular_function	iron ion binding
D	0005634	cellular_component	nucleus
D	0006397	biological_process	mRNA processing
D	0008270	molecular_function	zinc ion binding
D	0008419	molecular_function	RNA lariat debranching enzyme activity
D	0016787	molecular_function	hydrolase activity
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
E	0000375	biological_process	RNA splicing, via transesterification reactions
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005506	molecular_function	iron ion binding
E	0005634	cellular_component	nucleus
E	0006397	biological_process	mRNA processing
E	0008270	molecular_function	zinc ion binding
E	0008419	molecular_function	RNA lariat debranching enzyme activity
E	0016787	molecular_function	hydrolase activity
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN A 401

Chain	Residue
A	ASP45
A	ASN90
A	HIS180
A	HIS230
V	A2P501
V	HOH701

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 402

Chain	Residue
A	PRO146
A	HOH502
A	HOH508
A	HOH678
A	ARG50
A	ASN95
A	HIS99

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 403

Chain	Residue
A	GLN163
A	SER298
A	ILE299
A	SER300
A	HOH622

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MN B 401

Chain	Residue
B	ASP45
B	ASN90
B	HIS180
B	HIS230
W	A2P501
W	HOH701

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 B 402

Chain	Residue
A	LYS320
B	TYR51
B	TYR74
B	HOH600
B	HOH656

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 B 403

Chain	Residue
B	ARG50
B	ASN95
B	HIS99
B	HOH536
B	HOH603
B	HOH619
B	HOH631

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MN C 401

Chain	Residue
C	ASP45
C	ASN90
C	HIS180
C	HIS230
C	HOH725
X	A2P501

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 C 402

Chain	Residue
B	THR307
B	LYS308
C	LYS215

---

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 C 403

Chain	Residue
C	ARG50
C	ASN95
C	HIS99
C	HOH501
C	HOH598
C	HOH689

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 C 404

Chain	Residue
C	LYS18
C	TYR64
C	HOH710
X	A2P501

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MN D 401

Chain	Residue
D	ASP45
D	ASN90
D	HIS180
D	HIS230
D	HOH691
Y	A2P501

---

site_id	AD3
Number of Residues	8
Details	binding site for residue SO4 D 402

Chain	Residue
D	ARG50
D	ASN95
D	HIS99
D	PRO146
D	HOH509
D	HOH522
D	HOH583
D	HOH677

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MN E 401

Chain	Residue
E	ASP45
E	ASN90
E	HIS180
E	HIS230
Z	A2P501
Z	HOH703

---

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 E 402

Chain	Residue
E	ARG50
E	ASN95
E	HIS99
E	HOH555
E	HOH584
E	HOH615

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Region: {"description":"Lariat recognition loop","evidences":[{"source":"PubMed","id":"27930312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27930312","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28504306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UKI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25123664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27930312","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28504306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PEF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UKI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25123664","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2022","submissionDatabase":"PDB data bank","title":"Dbr1 in complex with 5-mer cleavage product.","authors":["Clark N.E.","Taylor A.B."]}},{"source":"PDB","id":"4PEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25123664","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2022","submissionDatabase":"PDB data bank","title":"Dbr1 in complex with 5-mer cleavage product.","authors":["Clark N.E.","Taylor A.B."]}},{"source":"PDB","id":"4PEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25123664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25123664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27930312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K78","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25123664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27930312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K78","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27930312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PEI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---