4OKN
Crystal structure of human muscle L-lactate dehydrogenase, ternary complex with NADH and oxalate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1990204 | cellular_component | oxidoreductase complex |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1990204 | cellular_component | oxidoreductase complex |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005829 | cellular_component | cytosol |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0006090 | biological_process | pyruvate metabolic process |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0045296 | molecular_function | cadherin binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 1990204 | cellular_component | oxidoreductase complex |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005829 | cellular_component | cytosol |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0006090 | biological_process | pyruvate metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0045296 | molecular_function | cadherin binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 1990204 | cellular_component | oxidoreductase complex |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005829 | cellular_component | cytosol |
| E | 0006089 | biological_process | lactate metabolic process |
| E | 0006090 | biological_process | pyruvate metabolic process |
| E | 0006096 | biological_process | glycolytic process |
| E | 0016020 | cellular_component | membrane |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0045296 | molecular_function | cadherin binding |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 1990204 | cellular_component | oxidoreductase complex |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005829 | cellular_component | cytosol |
| F | 0006089 | biological_process | lactate metabolic process |
| F | 0006090 | biological_process | pyruvate metabolic process |
| F | 0006096 | biological_process | glycolytic process |
| F | 0016020 | cellular_component | membrane |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0019752 | biological_process | carboxylic acid metabolic process |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0045296 | molecular_function | cadherin binding |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 1990204 | cellular_component | oxidoreductase complex |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005829 | cellular_component | cytosol |
| G | 0006089 | biological_process | lactate metabolic process |
| G | 0006090 | biological_process | pyruvate metabolic process |
| G | 0006096 | biological_process | glycolytic process |
| G | 0016020 | cellular_component | membrane |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| G | 0019752 | biological_process | carboxylic acid metabolic process |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0045296 | molecular_function | cadherin binding |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 1990204 | cellular_component | oxidoreductase complex |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005829 | cellular_component | cytosol |
| H | 0006089 | biological_process | lactate metabolic process |
| H | 0006090 | biological_process | pyruvate metabolic process |
| H | 0006096 | biological_process | glycolytic process |
| H | 0016020 | cellular_component | membrane |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| H | 0019752 | biological_process | carboxylic acid metabolic process |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0045296 | molecular_function | cadherin binding |
| H | 0070062 | cellular_component | extracellular exosome |
| H | 1990204 | cellular_component | oxidoreductase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAI A 401 |
| Chain | Residue |
| A | GLY29 |
| A | ALA98 |
| A | ARG99 |
| A | GLN100 |
| A | PHE119 |
| A | ILE120 |
| A | VAL136 |
| A | ASN138 |
| A | SER161 |
| A | HIS193 |
| A | THR248 |
| A | ALA30 |
| A | ILE252 |
| A | OXL402 |
| A | HOH502 |
| A | HOH540 |
| A | HOH556 |
| A | HOH561 |
| A | HOH584 |
| A | HOH585 |
| G | ASN108 |
| A | VAL31 |
| A | ASP52 |
| A | VAL53 |
| A | ILE54 |
| A | THR95 |
| A | ALA96 |
| A | GLY97 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OXL A 402 |
| Chain | Residue |
| A | GLN100 |
| A | ARG106 |
| A | ASN138 |
| A | ARG169 |
| A | HIS193 |
| A | ALA238 |
| A | THR248 |
| A | NAI401 |
| A | HOH556 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | ASN164 |
| A | SER167 |
| A | ARG171 |
| A | PRO272 |
| B | LEU70 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE OXL B 401 |
| Chain | Residue |
| B | ASN138 |
| B | ARG169 |
| B | HIS193 |
| B | THR248 |
| B | HOH592 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 402 |
| Chain | Residue |
| B | ARG171 |
| B | HIS186 |
| B | HOH516 |
| B | HOH519 |
| B | HOH541 |
| B | HOH546 |
| D | LEU183 |
| D | HIS186 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE KAN B 403 |
| Chain | Residue |
| B | ASP52 |
| B | VAL53 |
| B | ALA96 |
| B | GLY97 |
| B | ARG99 |
| B | ARG112 |
| B | ILE116 |
| B | PHE119 |
| B | ILE120 |
| H | GLU55 |
| H | HOH556 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAI C 401 |
| Chain | Residue |
| C | GLY29 |
| C | ALA30 |
| C | VAL31 |
| C | ASP52 |
| C | VAL53 |
| C | ILE54 |
| C | LYS57 |
| C | THR95 |
| C | ALA96 |
| C | GLY97 |
| C | ALA98 |
| C | ARG99 |
| C | ASN113 |
| C | ILE120 |
| C | VAL136 |
| C | ASN138 |
| C | SER161 |
| C | HIS193 |
| C | THR248 |
| C | ILE252 |
| C | OXL402 |
| C | HOH503 |
| C | HOH509 |
| C | HOH525 |
| C | HOH528 |
| C | HOH544 |
| C | HOH575 |
| C | HOH579 |
| C | HOH593 |
| C | HOH604 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OXL C 402 |
| Chain | Residue |
| C | LEU165 |
| C | ARG169 |
| C | HIS193 |
| C | ALA238 |
| C | THR248 |
| C | NAI401 |
| C | HOH544 |
| C | GLN100 |
| C | ARG106 |
| C | ASN138 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 403 |
| Chain | Residue |
| C | ASN164 |
| C | SER167 |
| C | ARG171 |
| C | PRO272 |
| D | LEU70 |
| site_id | BC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAI D 401 |
| Chain | Residue |
| D | GLY29 |
| D | ALA30 |
| D | VAL31 |
| D | ASP52 |
| D | VAL53 |
| D | ILE54 |
| D | LYS57 |
| D | THR95 |
| D | ALA96 |
| D | GLY97 |
| D | ALA98 |
| D | ARG99 |
| D | GLN100 |
| D | ASN113 |
| D | ILE116 |
| D | ILE120 |
| D | VAL136 |
| D | ASN138 |
| D | SER161 |
| D | LEU165 |
| D | HIS193 |
| D | THR248 |
| D | ILE252 |
| D | OXL402 |
| D | HOH501 |
| D | HOH525 |
| D | HOH550 |
| D | HOH563 |
| D | HOH589 |
| D | HOH590 |
| D | HOH593 |
| D | HOH629 |
| E | GLY103 |
| E | ASN108 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OXL D 402 |
| Chain | Residue |
| D | GLN100 |
| D | ARG106 |
| D | ASN138 |
| D | ARG169 |
| D | HIS193 |
| D | ALA238 |
| D | THR248 |
| D | NAI401 |
| D | HOH589 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 403 |
| Chain | Residue |
| C | LEU70 |
| D | ASN164 |
| D | SER167 |
| D | ARG171 |
| D | PRO272 |
| D | HOH596 |
| site_id | BC4 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAI E 401 |
| Chain | Residue |
| E | GLY29 |
| E | ALA30 |
| E | VAL31 |
| E | ASP52 |
| E | VAL53 |
| E | ILE54 |
| E | LYS57 |
| E | THR95 |
| E | ALA96 |
| E | GLY97 |
| E | ALA98 |
| E | ARG99 |
| E | GLN100 |
| E | ASN113 |
| E | ILE116 |
| E | ILE120 |
| E | VAL136 |
| E | ASN138 |
| E | SER161 |
| E | LEU165 |
| E | HIS193 |
| E | THR248 |
| E | ILE252 |
| E | OXL402 |
| E | HOH504 |
| E | HOH509 |
| E | HOH514 |
| E | HOH547 |
| E | HOH571 |
| E | HOH575 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OXL E 402 |
| Chain | Residue |
| E | GLN100 |
| E | ARG106 |
| E | ASN138 |
| E | ARG169 |
| E | HIS193 |
| E | ALA238 |
| E | THR248 |
| E | NAI401 |
| E | HOH514 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 403 |
| Chain | Residue |
| E | ASN164 |
| E | SER167 |
| E | ARG171 |
| E | PRO272 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 404 |
| Chain | Residue |
| D | GLY97 |
| D | ALA98 |
| D | ILE116 |
| D | HOH563 |
| D | HOH578 |
| E | ASN108 |
| site_id | BC8 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAI F 401 |
| Chain | Residue |
| C | GLN111 |
| F | GLY29 |
| F | ALA30 |
| F | VAL31 |
| F | ASP52 |
| F | VAL53 |
| F | ILE54 |
| F | LYS57 |
| F | THR95 |
| F | ALA96 |
| F | GLY97 |
| F | ALA98 |
| F | ARG99 |
| F | ILE116 |
| F | VAL136 |
| F | ASN138 |
| F | SER161 |
| F | HIS193 |
| F | THR248 |
| F | ILE252 |
| F | OXL402 |
| F | HOH501 |
| F | HOH503 |
| F | HOH544 |
| F | HOH566 |
| F | HOH567 |
| F | HOH589 |
| F | HOH596 |
| site_id | BC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OXL F 402 |
| Chain | Residue |
| F | GLN100 |
| F | ARG106 |
| F | ASN138 |
| F | ARG169 |
| F | HIS193 |
| F | ALA238 |
| F | THR248 |
| F | NAI401 |
| F | HOH596 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 F 403 |
| Chain | Residue |
| E | LEU70 |
| F | ASN164 |
| F | SER167 |
| F | ARG171 |
| F | PRO272 |
| site_id | CC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAI G 401 |
| Chain | Residue |
| G | GLY29 |
| G | ALA30 |
| G | VAL31 |
| G | ASP52 |
| G | VAL53 |
| G | ILE54 |
| G | LYS57 |
| G | THR95 |
| G | ALA96 |
| G | GLY97 |
| G | ALA98 |
| G | ARG99 |
| G | GLN100 |
| G | ILE116 |
| G | VAL136 |
| G | ASN138 |
| G | SER161 |
| G | LEU165 |
| G | HIS193 |
| G | THR248 |
| G | ILE252 |
| G | OXL402 |
| G | HOH502 |
| G | HOH510 |
| G | HOH515 |
| G | HOH530 |
| G | HOH576 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OXL G 402 |
| Chain | Residue |
| G | GLN100 |
| G | ARG106 |
| G | ASN138 |
| G | ARG169 |
| G | HIS193 |
| G | ALA238 |
| G | THR248 |
| G | NAI401 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 G 403 |
| Chain | Residue |
| G | ASN164 |
| G | SER167 |
| G | ARG171 |
| G | PRO272 |
| H | LEU70 |
| site_id | CC5 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAI H 401 |
| Chain | Residue |
| H | GLY29 |
| H | ALA30 |
| H | VAL31 |
| H | ASP52 |
| H | ILE54 |
| H | THR95 |
| H | ALA96 |
| H | GLY97 |
| H | ALA98 |
| H | ARG99 |
| H | ILE116 |
| H | PHE119 |
| H | ILE120 |
| H | VAL136 |
| H | ASN138 |
| H | SER161 |
| H | LEU165 |
| H | HIS193 |
| H | THR248 |
| H | ILE252 |
| H | OXL402 |
| H | HOH502 |
| H | HOH507 |
| H | HOH517 |
| H | HOH521 |
| H | HOH550 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OXL H 402 |
| Chain | Residue |
| H | GLN100 |
| H | ARG106 |
| H | ASN138 |
| H | ARG169 |
| H | HIS193 |
| H | ALA238 |
| H | THR248 |
| H | NAI401 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 H 403 |
| Chain | Residue |
| G | LEU70 |
| H | ASN164 |
| H | SER167 |
| H | ARG171 |
| H | TRP188 |
| H | PRO272 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
| Chain | Residue | Details |
| A | LEU190-SER196 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS193 | |
| B | HIS193 | |
| C | HIS193 | |
| D | HIS193 | |
| E | HIS193 | |
| F | HIS193 | |
| G | HIS193 | |
| H | HIS193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11276087 |
| Chain | Residue | Details |
| A | GLY29 | |
| E | ARG99 | |
| F | GLY29 | |
| F | ARG99 | |
| G | GLY29 | |
| G | ARG99 | |
| H | GLY29 | |
| H | ARG99 | |
| A | ARG99 | |
| B | GLY29 | |
| B | ARG99 | |
| C | GLY29 | |
| C | ARG99 | |
| D | GLY29 | |
| D | ARG99 | |
| E | GLY29 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG106 | |
| C | ASN138 | |
| C | ARG169 | |
| C | THR248 | |
| D | ARG106 | |
| D | ASN138 | |
| D | ARG169 | |
| D | THR248 | |
| E | ARG106 | |
| E | ASN138 | |
| E | ARG169 | |
| A | ASN138 | |
| E | THR248 | |
| F | ARG106 | |
| F | ASN138 | |
| F | ARG169 | |
| F | THR248 | |
| G | ARG106 | |
| G | ASN138 | |
| G | ARG169 | |
| G | THR248 | |
| H | ARG106 | |
| A | ARG169 | |
| H | ASN138 | |
| H | ARG169 | |
| H | THR248 | |
| A | THR248 | |
| B | ARG106 | |
| B | ASN138 | |
| B | ARG169 | |
| B | THR248 | |
| C | ARG106 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 | |
| E | ALA2 | |
| F | ALA2 | |
| G | ALA2 | |
| H | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| A | LYS5 | |
| D | LYS5 | |
| D | LYS118 | |
| D | LYS318 | |
| E | LYS5 | |
| E | LYS118 | |
| E | LYS318 | |
| F | LYS5 | |
| F | LYS118 | |
| F | LYS318 | |
| G | LYS5 | |
| A | LYS118 | |
| G | LYS118 | |
| G | LYS318 | |
| H | LYS5 | |
| H | LYS118 | |
| H | LYS318 | |
| A | LYS318 | |
| B | LYS5 | |
| B | LYS118 | |
| B | LYS318 | |
| C | LYS5 | |
| C | LYS118 | |
| C | LYS318 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR10 | |
| B | TYR10 | |
| C | TYR10 | |
| D | TYR10 | |
| E | TYR10 | |
| F | TYR10 | |
| G | TYR10 | |
| H | TYR10 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS14 | |
| D | LYS14 | |
| D | LYS81 | |
| D | LYS126 | |
| E | LYS14 | |
| E | LYS81 | |
| E | LYS126 | |
| F | LYS14 | |
| F | LYS81 | |
| F | LYS126 | |
| G | LYS14 | |
| A | LYS81 | |
| G | LYS81 | |
| G | LYS126 | |
| H | LYS14 | |
| H | LYS81 | |
| H | LYS126 | |
| A | LYS126 | |
| B | LYS14 | |
| B | LYS81 | |
| B | LYS126 | |
| C | LYS14 | |
| C | LYS81 | |
| C | LYS126 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR18 | |
| B | THR18 | |
| C | THR18 | |
| D | THR18 | |
| E | THR18 | |
| F | THR18 | |
| G | THR18 | |
| H | THR18 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS57 | |
| B | LYS57 | |
| C | LYS57 | |
| D | LYS57 | |
| E | LYS57 | |
| F | LYS57 | |
| G | LYS57 | |
| H | LYS57 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| A | LYS224 | |
| D | LYS224 | |
| D | LYS232 | |
| D | LYS243 | |
| E | LYS224 | |
| E | LYS232 | |
| E | LYS243 | |
| F | LYS224 | |
| F | LYS232 | |
| F | LYS243 | |
| G | LYS224 | |
| A | LYS232 | |
| G | LYS232 | |
| G | LYS243 | |
| H | LYS224 | |
| H | LYS232 | |
| H | LYS243 | |
| A | LYS243 | |
| B | LYS224 | |
| B | LYS232 | |
| B | LYS243 | |
| C | LYS224 | |
| C | LYS232 | |
| C | LYS243 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| A | TYR239 | |
| B | TYR239 | |
| C | TYR239 | |
| D | TYR239 | |
| E | TYR239 | |
| F | TYR239 | |
| G | TYR239 | |
| H | TYR239 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P04642 |
| Chain | Residue | Details |
| A | THR309 | |
| E | THR322 | |
| F | THR309 | |
| F | THR322 | |
| G | THR309 | |
| G | THR322 | |
| H | THR309 | |
| H | THR322 | |
| A | THR322 | |
| B | THR309 | |
| B | THR322 | |
| C | THR309 | |
| C | THR322 | |
| D | THR309 | |
| D | THR322 | |
| E | THR309 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER310 | |
| B | SER310 | |
| C | SER310 | |
| D | SER310 | |
| E | SER310 | |
| F | SER310 | |
| G | SER310 | |
| H | SER310 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 16 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS57 | |
| F | LYS57 | |
| G | LYS57 | |
| H | LYS57 | |
| B | LYS57 | |
| C | LYS57 | |
| D | LYS57 | |
| E | LYS57 |
