4OFG

Co-crystal structure of carboxy cGMP binding domain of Plasmodium falciparum PKG with cGMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005952	cellular_component	cAMP-dependent protein kinase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PCG A 601

Chain	Residue
A	ILE465
A	THR493
A	ALA494
A	GLN532
A	EOH622
A	LEU472
A	ARG473
A	PHE481
A	GLY482
A	GLU483
A	ARG484
A	ALA485
A	ARG492

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE N2P A 602

Chain	Residue
A	ASP479
A	TYR480
A	GLN532
A	LYS535

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE N2P A 603

Chain	Residue
A	LEU472
A	ARG473
A	LEU475
A	ASP479
A	N2P605
A	EOH619

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE N2P A 604

Chain	Residue
A	ALA402
A	ASP405
A	LYS409
A	GLU432
A	ARG454
A	ASP509
A	EOH623

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE N2P A 605

Chain	Residue
A	ARG528
A	MET531
A	N2P603
A	HOH748

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE N2P A 606

Chain	Residue
A	LEU486
A	LEU487
A	LYS510
A	GLN518

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE N2P A 607

Chain	Residue
A	TYR406
A	SER511
A	GLN515

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 608

Chain	Residue
A	GLY452
A	SER453
A	ARG454
A	TYR456
A	LYS469
A	ARG492
A	HOH703

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 609

Chain	Residue
A	TYR417
A	ARG420
A	HIS524
A	ARG528
A	MET531
A	EOH611
A	HOH748

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 610

Chain	Residue
A	PHE434
A	ARG435
A	ARG435
A	THR436

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EOH A 611

Chain	Residue
A	ILE418
A	ARG420
A	SO4609

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 612

Chain	Residue
A	TYR406
A	ASP424
A	HOH719
A	HOH741

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EOH A 613

Chain	Residue
A	GLN515

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EOH A 614

Chain	Residue
A	TYR439
A	ARG454
A	TYR456

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 615

Chain	Residue
A	TYR444
A	GLN447
A	GLU450
A	LYS469

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EOH A 616

Chain	Residue
A	LYS467
A	ASN468

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EOH A 617

Chain	Residue
A	LYS467

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 618

Chain	Residue
A	TYR417
A	ARG420
A	MET531
A	THR534

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EOH A 619

Chain	Residue
A	GLU462
A	ARG473
A	THR474
A	THR474
A	N2P603

---

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EOH A 620

Chain	Residue
A	THR437
A	ARG438

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EOH A 621

Chain	Residue
A	SER403
A	TYR444

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EOH A 622

Chain	Residue
A	LYS467
A	ASP533
A	PCG601

---

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EOH A 623

Chain	Residue
A	HOH747
A	ALA433
A	ARG435
A	ARG454
A	PHE507
A	ASP509
A	N2P604

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIqEGEvGSrFYIIknG

Chain	Residue	Details
A	ILE445-GLY461

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGErALlydep......RTAsViS

Chain	Residue	Details
A	PHE481-SER498

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	99
Details	Region: {"description":"cNMP-binding domain 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00060","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8I719","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Part of a catalytic triad required for cGMP binding and cGMP-dependent kinase activity","evidences":[{"source":"UniProtKB","id":"Q8I719","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---