Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PCG A 601 |
| Chain | Residue |
| A | ILE465 |
| A | THR493 |
| A | ALA494 |
| A | GLN532 |
| A | EOH622 |
| A | LEU472 |
| A | ARG473 |
| A | PHE481 |
| A | GLY482 |
| A | GLU483 |
| A | ARG484 |
| A | ALA485 |
| A | ARG492 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE N2P A 602 |
| Chain | Residue |
| A | ASP479 |
| A | TYR480 |
| A | GLN532 |
| A | LYS535 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE N2P A 603 |
| Chain | Residue |
| A | LEU472 |
| A | ARG473 |
| A | LEU475 |
| A | ASP479 |
| A | N2P605 |
| A | EOH619 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE N2P A 604 |
| Chain | Residue |
| A | ALA402 |
| A | ASP405 |
| A | LYS409 |
| A | GLU432 |
| A | ARG454 |
| A | ASP509 |
| A | EOH623 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE N2P A 605 |
| Chain | Residue |
| A | ARG528 |
| A | MET531 |
| A | N2P603 |
| A | HOH748 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE N2P A 606 |
| Chain | Residue |
| A | LEU486 |
| A | LEU487 |
| A | LYS510 |
| A | GLN518 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE N2P A 607 |
| Chain | Residue |
| A | TYR406 |
| A | SER511 |
| A | GLN515 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 608 |
| Chain | Residue |
| A | GLY452 |
| A | SER453 |
| A | ARG454 |
| A | TYR456 |
| A | LYS469 |
| A | ARG492 |
| A | HOH703 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 609 |
| Chain | Residue |
| A | TYR417 |
| A | ARG420 |
| A | HIS524 |
| A | ARG528 |
| A | MET531 |
| A | EOH611 |
| A | HOH748 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 610 |
| Chain | Residue |
| A | PHE434 |
| A | ARG435 |
| A | ARG435 |
| A | THR436 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EOH A 611 |
| Chain | Residue |
| A | ILE418 |
| A | ARG420 |
| A | SO4609 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EOH A 612 |
| Chain | Residue |
| A | TYR406 |
| A | ASP424 |
| A | HOH719 |
| A | HOH741 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EOH A 613 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EOH A 614 |
| Chain | Residue |
| A | TYR439 |
| A | ARG454 |
| A | TYR456 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EOH A 615 |
| Chain | Residue |
| A | TYR444 |
| A | GLN447 |
| A | GLU450 |
| A | LYS469 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EOH A 616 |
| Chain | Residue |
| A | LYS467 |
| A | ASN468 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EOH A 617 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EOH A 618 |
| Chain | Residue |
| A | TYR417 |
| A | ARG420 |
| A | MET531 |
| A | THR534 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EOH A 619 |
| Chain | Residue |
| A | GLU462 |
| A | ARG473 |
| A | THR474 |
| A | THR474 |
| A | N2P603 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EOH A 620 |
| Chain | Residue |
| A | THR437 |
| A | ARG438 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EOH A 621 |
| Chain | Residue |
| A | SER403 |
| A | TYR444 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EOH A 622 |
| Chain | Residue |
| A | LYS467 |
| A | ASP533 |
| A | PCG601 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EOH A 623 |
| Chain | Residue |
| A | HOH747 |
| A | ALA433 |
| A | ARG435 |
| A | ARG454 |
| A | PHE507 |
| A | ASP509 |
| A | N2P604 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIqEGEvGSrFYIIknG |
| Chain | Residue | Details |
| A | ILE445-GLY461 | |
| site_id | PS00889 |
| Number of Residues | 18 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGErALlydep......RTAsViS |
| Chain | Residue | Details |
| A | PHE481-SER498 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ARG473 | |
| A | GLY482 | |
| A | GLU483 | |
| A | ALA485 | |
| A | ARG492 | |
| A | THR493 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Part of a catalytic triad required for cGMP binding and cGMP-dependent kinase activity => ECO:0000269|PubMed:25646845 |
| Chain | Residue | Details |
| A | ARG484 | |
| A | GLN532 | |
| A | ASP533 | |
