4OAK

Crystal structure of vancomycin resistance D,D-dipeptidase/D,D-pentapeptidase VanXYc D59S mutant in complex with D-Alanine-D-Alanine and copper (II)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004180	molecular_function	carboxypeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0160237	molecular_function	D-Ala-D-Ala dipeptidase activity
B	0003824	molecular_function	catalytic activity
B	0004180	molecular_function	carboxypeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0160237	molecular_function	D-Ala-D-Ala dipeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 201

Chain	Residue
A	HIS95
A	ASP102
A	HIS156
A	DAL202

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 204

Chain	Residue
A	TYR152
A	HOH431
A	GLU142
A	ASP143
A	LYS144
A	GLN145
A	SER151

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 205

Chain	Residue
A	GLU66
A	HOH326
A	HOH352
A	HOH415
B	GLU66
B	HOH420

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 206

Chain	Residue
B	ASP112

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 207

Chain	Residue
A	ARG69
B	HOH393

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 208

Chain	Residue
A	THR63

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 209

Chain	Residue
A	HIS11
A	HOH349

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PE3 A 210

Chain	Residue
A	PHE189
A	HOH465
B	HIS179
B	ALA183

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PE3 A 211

Chain	Residue
A	HIS179
A	ALA183
A	HOH456
B	PHE189

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU B 201

Chain	Residue
B	HIS95
B	ASP102
B	HIS156
B	DAL202

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DAL B 202

Chain	Residue
B	PHE86
B	HIS95
B	ASP102
B	ILE114
B	TRP155
B	HIS156
B	CU201
B	DAL203

---

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DAL B 203

Chain	Residue
B	ARG62
B	GLN67
B	PHE86
B	ALA88
B	SER93
B	HIS95
B	TYR140
B	GLU153
B	DAL202
B	HOH301

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 204

Chain	Residue
A	HIS21
A	LEU22
B	ARG68
B	ARG69
B	HOH328

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 205

Chain	Residue
A	THR63
A	HOH352
B	THR63
B	LYS65
B	ARG69
B	HOH326

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 206

Chain	Residue
B	HIS11

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 207

Chain	Residue
B	ASP143

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PE3 B 208

Chain	Residue
B	MET1
B	PRO20
B	HIS21
B	GLN35

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PE3 B 209

Chain	Residue
B	TRP173
B	GLU177
B	ASP180

---

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR LINKED RESIDUES A 202 to 203

Chain	Residue
A	GLN67
A	PHE86
A	ALA88
A	SER93
A	HIS95
A	ASP102
A	GLU153
A	TRP155
A	HIS156
A	CU201
A	HOH301

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"catalytic acid/base residue","evidences":[{"source":"PubMed","id":"24711382","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"4OAK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24711382","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OAK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PDB","id":"4MUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MUS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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