4NYH

Orthorhombic crystal form of pir1 dual specificity phosphatase core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation
B	0006470	biological_process	protein dephosphorylation
B	0016311	biological_process	dephosphorylation
C	0006470	biological_process	protein dephosphorylation
C	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 301

Chain	Residue
A	SER152
A	HOH499
A	THR153
A	HIS154
A	GLY155
A	LEU156
A	ASN157
A	ARG158
A	ARG192
A	HOH445

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 302

Chain	Residue
A	THR94
A	TYR95
A	THR96
A	THR153
A	ARG158

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 B 301

Chain	Residue
B	SER152
B	THR153
B	HIS154
B	GLY155
B	LEU156
B	ASN157
B	ARG158
B	HOH430
B	HOH544

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 302

Chain	Residue
B	THR94
B	TYR95
B	THR96
B	THR153
B	ARG158

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 301

Chain	Residue
C	SER152
C	THR153
C	HIS154
C	GLY155
C	LEU156
C	ASN157
C	ARG158
C	HOH410

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site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 302

Chain	Residue
C	THR94
C	TYR95
C	THR96
C	THR153
C	ARG158

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000269|PubMed:24447265, ECO:0000305|PubMed:9685386

Chain	Residue	Details
A	SER152
B	SER152
C	SER152

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site_id	SWS_FT_FI2
Number of Residues	3
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255

Chain	Residue	Details
A	ARG158
B	ARG158
C	ARG158

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:24531476

Chain	Residue	Details
A	THR153
B	THR153
C	THR153

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