4NRU

Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
B	0006351	biological_process	DNA-templated transcription
B	0039694	biological_process	viral RNA genome replication
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0004386	molecular_function	helicase activity
C	0005524	molecular_function	ATP binding
C	0006351	biological_process	DNA-templated transcription
C	0039694	biological_process	viral RNA genome replication
D	0003723	molecular_function	RNA binding
D	0003968	molecular_function	RNA-directed RNA polymerase activity
D	0004386	molecular_function	helicase activity
D	0005524	molecular_function	ATP binding
D	0006351	biological_process	DNA-templated transcription
D	0039694	biological_process	viral RNA genome replication
E	0003723	molecular_function	RNA binding
E	0003968	molecular_function	RNA-directed RNA polymerase activity
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
E	0006351	biological_process	DNA-templated transcription
E	0039694	biological_process	viral RNA genome replication
F	0003723	molecular_function	RNA binding
F	0003968	molecular_function	RNA-directed RNA polymerase activity
F	0004386	molecular_function	helicase activity
F	0005524	molecular_function	ATP binding
F	0006351	biological_process	DNA-templated transcription
F	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 2NG A 1101

Chain	Residue
A	LEU169
A	GLN439
A	HOH1253
A	HOH1315
A	HOH1343
A	HOH1401
A	HOH1562
A	MET219
A	MET221
A	ARG392
A	ARG393
A	TRP417
A	THR418
A	LYS419
A	ARG436

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1102

Chain	Residue
A	ASP240
A	ASP344
A	GLU345
A	SER389
A	HOH1252

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 2NG B 1101

Chain	Residue
B	PHE29
B	LEU169
B	MET219
B	MET221
B	TYR341
B	ARG392
B	ARG393
B	GLN414
B	TRP417
B	THR418
B	LYS419
B	ARG436
B	GLN439
B	HOH1208
B	HOH1270
B	HOH1424
B	HOH1518

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1102

Chain	Residue
B	ASP240
B	ASP344
B	GLU345
B	SER389
B	HOH1473
B	HOH1478

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 2NG C 1101

Chain	Residue
C	LEU169
C	MET219
C	MET221
C	TYR341
C	ARG392
C	ARG393
C	GLN414
C	TRP417
C	THR418
C	LYS419
C	ARG436
C	GLN439
C	HOH1252
C	HOH1280
C	HOH1362
C	HOH1472

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 1102

Chain	Residue
C	ASP240
C	ASP344
C	GLU345
C	SER389
C	HOH1504

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2NG D 1101

Chain	Residue
D	LEU169
D	MET219
D	MET221
D	ARG392
D	ARG393
D	TRP417
D	THR418
D	LYS419
D	ARG436
D	GLN439
D	HOH1220
D	HOH1270
D	HOH1289

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 1102

Chain	Residue
D	ASP240
D	ASP344
D	GLU345
D	SER389
D	HOH1430

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 2NG E 1101

Chain	Residue
E	LEU169
E	MET219
E	MET221
E	TYR341
E	LEU391
E	ARG392
E	ARG393
E	GLN414
E	TRP417
E	THR418
E	LYS419
E	ARG436
E	GLN439
E	HOH1376

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2NG E 1102

Chain	Residue
E	ARG326
E	VAL327
E	ASP328
E	ARG364
E	HOH1216
E	HOH1381
E	HOH1387
E	LEU77
E	PRO79
E	GLU81

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG E 1103

Chain	Residue
E	ASP240
E	ASP344
E	GLU345
E	SER389

---

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2NG F 1101

Chain	Residue
F	LEU169
F	MET219
F	TYR341
F	LEU391
F	ARG392
F	GLN414
F	TRP417
F	THR418
F	LYS419
F	GLN439
F	HOH1236
F	HOH1312

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 1102

Chain	Residue
F	ASP240
F	ASP344
F	GLU345
F	SER389
F	HOH1225

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	726
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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