4NCL
Crystal structure of eukaryotic translation initiation factor eIF5B (517-970) from Chaetomium thermophilum in complex with GDP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE GDP A 1001 |
| Chain | Residue |
| A | HIS531 |
| A | LYS649 |
| A | ASP651 |
| A | ARG652 |
| A | SER716 |
| A | ALA717 |
| A | HIS718 |
| A | MG1002 |
| A | HOH1171 |
| A | HOH1192 |
| B | ASP845 |
| A | VAL532 |
| B | HOH1199 |
| A | ASP533 |
| A | THR534 |
| A | GLY535 |
| A | LYS536 |
| A | THR537 |
| A | LYS538 |
| A | ASN648 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | LYS536 |
| A | THR537 |
| A | GDP1001 |
| A | HOH1192 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GDP B 1001 |
| Chain | Residue |
| B | ASP533 |
| B | THR534 |
| B | GLY535 |
| B | LYS536 |
| B | THR537 |
| B | LYS538 |
| B | ASN648 |
| B | LYS649 |
| B | ASP651 |
| B | ARG652 |
| B | SER716 |
| B | ALA717 |
| B | HIS718 |
| B | MG1002 |
| B | HOH1154 |
| B | HOH1167 |
| B | HOH1195 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | THR537 |
| B | GDP1001 |
| B | HOH1154 |
| B | HOH1167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24686316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
