4N76
Structure of Thermus thermophilus Argonaute bound to guide DNA and cleaved target DNA with Mn2+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003677 | molecular_function | DNA binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004519 | molecular_function | endonuclease activity |
A | 0004520 | molecular_function | DNA endonuclease activity |
A | 0006260 | biological_process | DNA replication |
A | 0030145 | molecular_function | manganese ion binding |
A | 0044355 | biological_process | clearance of foreign intracellular DNA |
A | 0046872 | molecular_function | metal ion binding |
B | 0003676 | molecular_function | nucleic acid binding |
B | 0003677 | molecular_function | DNA binding |
B | 0003723 | molecular_function | RNA binding |
B | 0004519 | molecular_function | endonuclease activity |
B | 0004520 | molecular_function | DNA endonuclease activity |
B | 0006260 | biological_process | DNA replication |
B | 0030145 | molecular_function | manganese ion binding |
B | 0044355 | biological_process | clearance of foreign intracellular DNA |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN B 701 |
Chain | Residue |
B | GLN433 |
B | LYS457 |
B | VAL685 |
E | DT1 |
E | DA3 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN B 702 |
Chain | Residue |
B | MN703 |
F | DT10 |
B | ASP478 |
B | ALA479 |
B | GLU512 |
B | ASP546 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN B 703 |
Chain | Residue |
B | ASP478 |
B | ASP660 |
B | MN702 |
F | DT10 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DT B 704 |
Chain | Residue |
A | PRO37 |
A | ARG39 |
A | VAL42 |
B | ASN195 |
B | TYR197 |
B | PRO218 |
B | TYR226 |
B | HIS227 |
B | ARG232 |
B | PRO255 |
B | HIS256 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN C 101 |
Chain | Residue |
A | LYS457 |
A | VAL685 |
C | DT1 |
C | DA3 |
C | HOH201 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 |
Chain | Residue | Details |
A | ASP478 | |
A | ASP546 | |
A | ASP660 | |
B | ASP478 | |
B | ASP546 | |
B | ASP660 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 |
Chain | Residue | Details |
A | GLU512 | |
B | GLU512 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 |
Chain | Residue | Details |
A | ASP478 | |
B | ASP478 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 |
Chain | Residue | Details |
A | ASP546 | |
A | ASP660 | |
B | ASP546 | |
B | ASP660 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 |
Chain | Residue | Details |
A | VAL685 | |
B | VAL685 |