4MZF
Crystal structure of human Spindlin1 bound to histone H3(K4me3-R8me2a) peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0007276 | biological_process | gamete generation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 301 |
| Chain | Residue |
| B | ARG152 |
| B | LYS172 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 302 |
| Chain | Residue |
| B | HIS234 |
| B | GLU237 |
| B | HOH413 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 303 |
| Chain | Residue |
| B | HOH464 |
| B | HOH464 |
| B | HOH447 |
| B | HOH447 |
| B | HOH463 |
| B | HOH463 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Histone H3K4me3 and H3R8me2a binding => ECO:0000269|PubMed:23077255, ECO:0000269|PubMed:24589551 |
| Chain | Residue | Details |
| B | ASP173 | |
| B | GLN180 | |
| B | ASP184 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766 |
| Chain | Residue | Details |
| B | SER109 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER124 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER199 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| A | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P84228 |
| Chain | Residue | Details |
| A | DA28 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| A | LYS9 |
