4MLR
dihydrodipicolinate synthase from C. jejuni, Y110F mutation with pyruvate and Lysine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0044281 | biological_process | small molecule metabolic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0044281 | biological_process | small molecule metabolic process |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| C | 0009085 | biological_process | lysine biosynthetic process |
| C | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019877 | biological_process | diaminopimelate biosynthetic process |
| C | 0044281 | biological_process | small molecule metabolic process |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| D | 0009085 | biological_process | lysine biosynthetic process |
| D | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019877 | biological_process | diaminopimelate biosynthetic process |
| D | 0044281 | biological_process | small molecule metabolic process |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| E | 0009085 | biological_process | lysine biosynthetic process |
| E | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| E | 0016829 | molecular_function | lyase activity |
| E | 0019877 | biological_process | diaminopimelate biosynthetic process |
| E | 0044281 | biological_process | small molecule metabolic process |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| F | 0009085 | biological_process | lysine biosynthetic process |
| F | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| F | 0016829 | molecular_function | lyase activity |
| F | 0019877 | biological_process | diaminopimelate biosynthetic process |
| F | 0044281 | biological_process | small molecule metabolic process |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| G | 0009085 | biological_process | lysine biosynthetic process |
| G | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| G | 0016829 | molecular_function | lyase activity |
| G | 0019877 | biological_process | diaminopimelate biosynthetic process |
| G | 0044281 | biological_process | small molecule metabolic process |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| H | 0009085 | biological_process | lysine biosynthetic process |
| H | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| H | 0016829 | molecular_function | lyase activity |
| H | 0019877 | biological_process | diaminopimelate biosynthetic process |
| H | 0044281 | biological_process | small molecule metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LYS A 301 |
| Chain | Residue |
| A | SER51 |
| A | ALA52 |
| A | LEU54 |
| A | HIS59 |
| A | PHE110 |
| A | LYS302 |
| D | ASN84 |
| D | GLU88 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LYS A 302 |
| Chain | Residue |
| A | GLU88 |
| A | LYS301 |
| D | SER51 |
| D | ALA52 |
| D | LEU54 |
| D | HIS59 |
| D | PHE110 |
| A | ASN84 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 303 |
| Chain | Residue |
| A | TYR261 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 304 |
| Chain | Residue |
| A | THR149 |
| A | ASP177 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 305 |
| Chain | Residue |
| A | LYS204 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 306 |
| Chain | Residue |
| A | HIS223 |
| A | PHE224 |
| A | ASP227 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE LYS B 301 |
| Chain | Residue |
| B | SER51 |
| B | ALA52 |
| B | LEU54 |
| B | HIS59 |
| C | ASN84 |
| C | GLU88 |
| C | LYS301 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 B 302 |
| Chain | Residue |
| B | GLN117 |
| B | ASP150 |
| B | THR151 |
| B | LYS154 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE B 303 |
| Chain | Residue |
| B | PRO183 |
| B | MET186 |
| B | GLY202 |
| B | LYS204 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE LYS C 301 |
| Chain | Residue |
| B | ASN84 |
| B | GLU88 |
| B | LYS301 |
| C | SER51 |
| C | ALA52 |
| C | LEU54 |
| C | HIS59 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 C 302 |
| Chain | Residue |
| C | GLN117 |
| C | TYR120 |
| C | ASP150 |
| C | THR151 |
| C | LYS154 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGE C 303 |
| Chain | Residue |
| C | PRO183 |
| C | MET186 |
| C | LYS204 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL C 304 |
| Chain | Residue |
| C | PRO140 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO D 301 |
| Chain | Residue |
| D | ARG272 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LYS E 301 |
| Chain | Residue |
| E | SER51 |
| E | ALA52 |
| E | LEU54 |
| E | HIS56 |
| E | HIS59 |
| E | PHE110 |
| E | HOH422 |
| F | ASN84 |
| F | GLU88 |
| F | LYS301 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PGE E 302 |
| Chain | Residue |
| E | PRO140 |
| E | GLY144 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO E 303 |
| Chain | Residue |
| E | ALA263 |
| E | ILE295 |
| E | GLY297 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO E 304 |
| Chain | Residue |
| E | TYR120 |
| E | LYS154 |
| site_id | CC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LYS F 301 |
| Chain | Residue |
| E | ASN84 |
| E | GLU88 |
| E | LYS301 |
| F | SER51 |
| F | ALA52 |
| F | LEU54 |
| F | HIS56 |
| F | HIS59 |
| F | PHE110 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PGE F 302 |
| Chain | Residue |
| F | GLN117 |
| F | LYS154 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT F 303 |
| Chain | Residue |
| E | HIS56 |
| E | GLU88 |
| F | HIS56 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LYS G 301 |
| Chain | Residue |
| G | SER51 |
| G | ALA52 |
| G | LEU54 |
| G | HIS56 |
| G | HIS59 |
| H | ASN84 |
| H | GLU88 |
| H | LYS301 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO G 303 |
| Chain | Residue |
| G | GLU287 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LYS H 301 |
| Chain | Residue |
| H | ALA52 |
| H | LEU54 |
| H | HIS59 |
| H | PHE110 |
| G | ASN84 |
| G | GLU88 |
| G | LYS301 |
| H | SER51 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGE H 302 |
| Chain | Residue |
| H | GLN117 |
| H | TYR120 |
| H | LYS154 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Site: {"description":"Part of a proton relay during catalysis","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
