4MJP

E. coli sliding clamp in complex with (R)-Vedaprofen

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006271	biological_process	DNA strand elongation involved in DNA replication
A	0006974	biological_process	DNA damage response
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009360	cellular_component	DNA polymerase III complex
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
A	0042276	biological_process	error-prone translesion synthesis
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044787	biological_process	bacterial-type DNA replication
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006974	biological_process	DNA damage response
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009360	cellular_component	DNA polymerase III complex
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
B	0042276	biological_process	error-prone translesion synthesis
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044787	biological_process	bacterial-type DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A 401

Chain	Residue
A	ASP121
A	TRP122
A	ARG224

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE A 402

Chain	Residue
A	ARG7
A	ARG80
A	LEU82
B	GLN265

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 403

Chain	Residue
A	SER181

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG B 401

Chain	Residue
B	ARG80
B	LEU82
B	HOH665
B	ARG7

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 402

Chain	Residue
B	LEU262
B	ALA266
B	ARG269
B	HOH502
B	HOH795

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 27O B 403

Chain	Residue
B	ARG152
B	THR172
B	ARG240
B	PRO242
B	ASP243
B	ARG246
B	HOH748

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE B 404

Chain	Residue
B	ASP121
B	TRP122
B	ARG224
B	HOH724
B	HOH783

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Region: {"description":"2","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	120
Details	Region: {"description":"3","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---