4MHL
The crystal structure of human interleukin-11
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001960 | biological_process | negative regulation of cytokine-mediated signaling pathway |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005142 | molecular_function | interleukin-11 receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008083 | molecular_function | growth factor activity |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0030183 | biological_process | B cell differentiation |
| A | 0030219 | biological_process | megakaryocyte differentiation |
| A | 0033138 | biological_process | positive regulation of peptidyl-serine phosphorylation |
| A | 0038154 | biological_process | interleukin-11-mediated signaling pathway |
| A | 0043235 | cellular_component | receptor complex |
| A | 0043410 | biological_process | positive regulation of MAPK cascade |
| A | 0045444 | biological_process | fat cell differentiation |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046888 | biological_process | negative regulation of hormone secretion |
| A | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
| A | 0060302 | biological_process | negative regulation of cytokine activity |
| A | 1903659 | biological_process | regulation of complement-dependent cytotoxicity |
| A | 2000352 | biological_process | negative regulation of endothelial cell apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 201 |
| Chain | Residue |
| A | ARG54 |
| A | ARG61 |
| A | ARG132 |
| A | ARG135 |
| A | ARG139 |
| A | ARF205 |
| A | HOH310 |
| A | HOH337 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF A 202 |
| Chain | Residue |
| A | ARG132 |
| A | HOH323 |
| A | HOH324 |
| A | HOH366 |
| A | ALA51 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ARF A 203 |
| Chain | Residue |
| A | PRO65 |
| A | ALA66 |
| A | ASP67 |
| A | HIS70 |
| A | TRP168 |
| A | ILE171 |
| A | ARG172 |
| A | HIS175 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ARF A 204 |
| Chain | Residue |
| A | ASP62 |
| A | PRO65 |
| A | GLY127 |
| A | HOH323 |
| A | HOH326 |
| A | HOH346 |
| A | HOH366 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ARF A 205 |
| Chain | Residue |
| A | ARG54 |
| A | ARG139 |
| A | LEU142 |
| A | HIS182 |
| A | SO4201 |
| A | HOH337 |
| A | HOH348 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF A 206 |
| Chain | Residue |
| A | SER48 |
| A | ASP52 |
| A | ALA58 |
| A | ARG61 |
| A | HOH347 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Important for interaction with IL11RA and for the stimulation of cell proliferation","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for interaction with IL6ST and for the stimulation of cell proliferation","evidences":[{"source":"UniProtKB","id":"P47873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
