4MGJ

Crystal structure of cytochrome P450 2B4 F429H in complex with 4-CPI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0008392	molecular_function	arachidonic acid epoxygenase activity
A	0016020	cellular_component	membrane
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019373	biological_process	epoxygenase P450 pathway
A	0020037	molecular_function	heme binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046872	molecular_function	metal ion binding
A	0070330	molecular_function	aromatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM A 501

Chain	Residue
A	ARG98
A	THR306
A	ILE363
A	VAL367
A	HIS369
A	LEU392
A	PRO428
A	HIS429
A	SER430
A	ARG434
A	CYS436
A	VAL113
A	GLY438
A	CPZ502
A	ILE114
A	TRP121
A	ARG125
A	MET132
A	ALA298
A	GLY299
A	THR303

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CPZ A 502

Chain	Residue
A	ILE101
A	PHE297
A	ALA298
A	THR302
A	VAL477
A	HEM501

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: axial binding residue

Chain	Residue	Details
A	CYS436

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P00176

Chain	Residue	Details
A	SER128

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