Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4M8N

Crystal Structure of PlexinC1/Rap1B Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017154	molecular_function	semaphorin receptor activity
A	0071526	biological_process	semaphorin-plexin signaling pathway
B	0017154	molecular_function	semaphorin receptor activity
B	0071526	biological_process	semaphorin-plexin signaling pathway
C	0017154	molecular_function	semaphorin receptor activity
C	0071526	biological_process	semaphorin-plexin signaling pathway
D	0017154	molecular_function	semaphorin receptor activity
D	0071526	biological_process	semaphorin-plexin signaling pathway
E	0003924	molecular_function	GTPase activity
E	0003925	molecular_function	G protein activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005811	cellular_component	lipid droplet
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005911	cellular_component	cell-cell junction
E	0007165	biological_process	signal transduction
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0008283	biological_process	cell population proliferation
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0017156	biological_process	calcium-ion regulated exocytosis
E	0019003	molecular_function	GDP binding
E	0030033	biological_process	microvillus assembly
E	0032486	biological_process	Rap protein signal transduction
E	0033625	biological_process	positive regulation of integrin activation
E	0035577	cellular_component	azurophil granule membrane
E	0044877	molecular_function	protein-containing complex binding
E	0045121	cellular_component	membrane raft
E	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
E	0051649	biological_process	establishment of localization in cell
E	0061028	biological_process	establishment of endothelial barrier
E	0070062	cellular_component	extracellular exosome
E	0070161	cellular_component	anchoring junction
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0071320	biological_process	cellular response to cAMP
E	0098978	cellular_component	glutamatergic synapse
E	0099010	biological_process	modification of postsynaptic structure
E	1901888	biological_process	regulation of cell junction assembly
E	2000114	biological_process	regulation of establishment of cell polarity
E	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005811	cellular_component	lipid droplet
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005911	cellular_component	cell-cell junction
F	0007165	biological_process	signal transduction
F	0007264	biological_process	small GTPase-mediated signal transduction
F	0008283	biological_process	cell population proliferation
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0017156	biological_process	calcium-ion regulated exocytosis
F	0019003	molecular_function	GDP binding
F	0030033	biological_process	microvillus assembly
F	0032486	biological_process	Rap protein signal transduction
F	0033625	biological_process	positive regulation of integrin activation
F	0035577	cellular_component	azurophil granule membrane
F	0044877	molecular_function	protein-containing complex binding
F	0045121	cellular_component	membrane raft
F	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
F	0051649	biological_process	establishment of localization in cell
F	0061028	biological_process	establishment of endothelial barrier
F	0070062	cellular_component	extracellular exosome
F	0070161	cellular_component	anchoring junction
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0071320	biological_process	cellular response to cAMP
F	0098978	cellular_component	glutamatergic synapse
F	0099010	biological_process	modification of postsynaptic structure
F	1901888	biological_process	regulation of cell junction assembly
F	2000114	biological_process	regulation of establishment of cell polarity
F	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005811	cellular_component	lipid droplet
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005911	cellular_component	cell-cell junction
G	0007165	biological_process	signal transduction
G	0007264	biological_process	small GTPase-mediated signal transduction
G	0008283	biological_process	cell population proliferation
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0017156	biological_process	calcium-ion regulated exocytosis
G	0019003	molecular_function	GDP binding
G	0030033	biological_process	microvillus assembly
G	0032486	biological_process	Rap protein signal transduction
G	0033625	biological_process	positive regulation of integrin activation
G	0035577	cellular_component	azurophil granule membrane
G	0044877	molecular_function	protein-containing complex binding
G	0045121	cellular_component	membrane raft
G	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
G	0051649	biological_process	establishment of localization in cell
G	0061028	biological_process	establishment of endothelial barrier
G	0070062	cellular_component	extracellular exosome
G	0070161	cellular_component	anchoring junction
G	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
G	0071320	biological_process	cellular response to cAMP
G	0098978	cellular_component	glutamatergic synapse
G	0099010	biological_process	modification of postsynaptic structure
G	1901888	biological_process	regulation of cell junction assembly
G	2000114	biological_process	regulation of establishment of cell polarity
G	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005811	cellular_component	lipid droplet
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005911	cellular_component	cell-cell junction
H	0007165	biological_process	signal transduction
H	0007264	biological_process	small GTPase-mediated signal transduction
H	0008283	biological_process	cell population proliferation
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0017156	biological_process	calcium-ion regulated exocytosis
H	0019003	molecular_function	GDP binding
H	0030033	biological_process	microvillus assembly
H	0032486	biological_process	Rap protein signal transduction
H	0033625	biological_process	positive regulation of integrin activation
H	0035577	cellular_component	azurophil granule membrane
H	0044877	molecular_function	protein-containing complex binding
H	0045121	cellular_component	membrane raft
H	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
H	0051649	biological_process	establishment of localization in cell
H	0061028	biological_process	establishment of endothelial barrier
H	0070062	cellular_component	extracellular exosome
H	0070161	cellular_component	anchoring junction
H	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
H	0071320	biological_process	cellular response to cAMP
H	0098978	cellular_component	glutamatergic synapse
H	0099010	biological_process	modification of postsynaptic structure
H	1901888	biological_process	regulation of cell junction assembly
H	2000114	biological_process	regulation of establishment of cell polarity
H	2000301	biological_process	negative regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 200

Chain	Residue
E	SER17
E	THR35
E	ASP57
E	GDP201
E	AF3202

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GDP E 201

Chain	Residue
E	LYS16
E	SER17
E	ALA18
E	PHE28
E	GLU30
E	LYS31
E	TYR32
E	THR35
E	ASN116
E	LYS117
E	ASP119
E	LEU120
E	SER147
E	ALA148
E	LYS149
E	MG200
E	AF3202
A	ARG711
E	GLY13
E	VAL14
E	GLY15

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AF3 E 202

Chain	Residue
A	ARG711
E	SER11
E	GLY12
E	GLY13
E	LYS16
E	THR35
E	ALA59
E	GLY60
E	GLN63
E	MG200
E	GDP201

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 200

Chain	Residue
F	LYS16
F	SER17
F	THR35
F	ASP57
F	GDP201
F	AF3202

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GDP F 201

Chain	Residue
C	ARG711
F	GLY13
F	GLY15
F	LYS16
F	SER17
F	ALA18
F	PHE28
F	LYS31
F	TYR32
F	THR35
F	ASN116
F	LYS117
F	ASP119
F	SER147
F	ALA148
F	LYS149
F	MG200
F	AF3202

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AF3 F 202

Chain	Residue
C	ARG711
F	GLY12
F	LYS16
F	PRO34
F	THR35
F	ALA59
F	GLY60
F	GLN63
F	MG200
F	GDP201

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 200

Chain	Residue
G	SER17
G	THR35
G	ASP57
G	GDP201
G	AF3202

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP G 201

Chain	Residue
B	ARG711
G	GLY13
G	GLY15
G	LYS16
G	SER17
G	ALA18
G	GLU30
G	LYS31
G	TYR32
G	THR35
G	ASN116
G	LYS117
G	ASP119
G	SER147
G	ALA148
G	MG200
G	AF3202

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AF3 G 202

Chain	Residue
G	GLN63
G	MG200
G	GDP201
B	ARG711
G	GLY12
G	LYS16
G	THR35
G	ALA59
G	GLY60

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG H 200

Chain	Residue
H	LYS16
H	SER17
H	THR35
H	ASP57
H	THR58
H	GDP201
H	AF3202

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP H 201

Chain	Residue
H	GLY13
H	GLY15
H	LYS16
H	SER17
H	ALA18
H	PHE28
H	GLU30
H	LYS31
H	TYR32
H	THR35
H	LYS117
H	ASP119
H	SER147
H	ALA148
H	LYS149
H	MG200
H	AF3202

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AF3 H 202

Chain	Residue
D	ARG711
H	GLY12
H	LYS16
H	PRO34
H	THR35
H	THR58
H	ALA59
H	GLY60
H	GLN63
H	MG200
H	GDP201

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:18309292, ECO:0000269\|PubMed:22577140

Chain	Residue	Details
E	GLY10
G	ASP57
G	ASN116
G	SER147
H	GLY10
H	ASP57
H	ASN116
H	SER147
E	ASP57
E	ASN116
E	SER147
F	GLY10
F	ASP57
F	ASN116
F	SER147
G	GLY10

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: ADP-ribosylserine; by botulinum toxin => ECO:0000305\|PubMed:3141412

Chain	Residue	Details
E	SER39
F	SER39
G	SER39
H	SER39

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)